pI: 6.4333 |
Length (AA): 79 |
MW (Da): 8514 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_132328)
Species | Accession | Gene Product |
---|---|---|
Homo sapiens | ENSG00000167601 | AXL receptor tyrosine kinase |
Homo sapiens | 7301 | TYRO3 protein tyrosine kinase |
Homo sapiens | ENSG00000153208 | MER proto-oncogene, tyrosine kinase |
Mus musculus | ENSMUSG00000027298 | TYRO3 protein tyrosine kinase 3 |
Mus musculus | ENSMUSG00000014361 | c-mer proto-oncogene tyrosine kinase |
Mus musculus | ENSMUSG00000002602 | AXL receptor tyrosine kinase |
Schistosoma japonicum | Sjp_0308670 | IPR008957,Fibronectin, type III-like fold,domain-containing |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | AXL receptor tyrosine kinase | Compounds | References |
Homo sapiens | MER proto-oncogene, tyrosine kinase | Compounds | References |
Homo sapiens | TYRO3 protein tyrosine kinase | Compounds | References |