Detailed view for Sjp_0070320

Basic information

TDR Targets ID: 966690
Schistosoma japonicum, Tyrosine-protein kinase transforming protein Abl, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.2903 | Length (AA): 297 | MW (Da): 33432 | Paralog Number: 4

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00017   SH2 domain
PF00018   SH3 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0004713   protein tyrosine kinase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 278 6amv (A) 26 255 34.00 0.63 0.98 1.04808 0.51
57 114 2gnc (A) 7 57 27.00 0 0.48 0.362446 -0.13
58 292 5mo4 (A) 84 269 47.00 0 1 1.02142 0.58
165 259 1kc2 (A) 147 248 37.00 0.0000000011 1 0.864946 -1.26
233 290 4xey (B) 211 267 56.00 0.66 0.17 0.383346 0.85

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131234)

Species Accession Gene Product
Brugia malayi Bm1_30590   Tyrosine-protein kinase abl-1
Caenorhabditis elegans CELE_M79.1   Protein ABL-1, isoform B
Drosophila melanogaster Dmel_CG4032   Abl tyrosine kinase
Echinococcus granulosus EgrG_000904100   tyrosine protein kinase ABL1
Echinococcus multilocularis EmuJ_000526200   tyrosine protein kinase Abl
Echinococcus multilocularis EmuJ_000904100   tyrosine protein kinase ABL1
Homo sapiens ENSG00000143322   ABL proto-oncogene 2, non-receptor tyrosine kinase
Homo sapiens ENSG00000097007   ABL proto-oncogene 1, non-receptor tyrosine kinase
Loa Loa (eye worm) LOAG_09621   hypothetical protein
Loa Loa (eye worm) LOAG_05868   TK/ABL protein kinase
Mus musculus ENSMUSG00000026596   v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
Mus musculus ensembl-mmu:ENSMUSG00000026842   c-abl oncogene 1, non-receptor tyrosine kinase
Schistosoma japonicum Sjp_0070320   Tyrosine-protein kinase transforming protein Abl, putative
Schistosoma japonicum Sjp_0107860   Proto-oncogene tyrosine-protein kinase ABL1, putative
Schistosoma japonicum Sjp_0040100   Tyrosine-protein kinase transforming protein Abl, putative
Schistosoma japonicum Sjp_0315400   expressed protein
Schistosoma japonicum Sjp_0218720   expressed protein
Schistosoma mansoni Smp_128790   tyrosine kinase
Schmidtea mediterranea mk4.000165.19  
Schmidtea mediterranea mk4.001022.05  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Abelson murine leukemia virus Tyrosine-protein kinase V-ABL Compounds References
Mus musculus c-abl oncogene 1, non-receptor tyrosine kinase Compounds References
Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase Compounds References
Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0070320 (Schistosoma japonicum), Tyrosine-protein kinase transforming protein Abl, putative
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