Detailed view for PF3D7_0823300

Basic information

TDR Targets ID: 967
Plasmodium falciparum, histone acetyltransferase GCN5

Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.6389 | Length (AA): 1465 | MW (Da): 170918 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00583   Acetyltransferase (GNAT) family

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0008080   N-acetyltransferase activity  
GO:0005515   protein binding  
GO:0004402   histone acetyltransferase activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 23 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1130 1311 1ygh (A) 99 262 54.00 0 1 0.79 -1.73
1368 1481 2fsa (A) 60 173 30.00 0 1 0.45 -1.58
1388 1476 2fsa (A) 80 168 38.00 0.000000000017 1 0.75 -2.28
29 838 3vuo (A) 240 1149 22.00 0.09 0.91 0.490801 1.4
143 239 3ult (A) 6 107 29.00 0.0016 0.26 0.551112 -2.32
462 758 4en6 (B) 374 614 29.00 0.45 0.31 0.0596304 1.11
775 1038 4u0r (A) 172 494 17.00 0.15 0.01 0.344305 -0.86
1129 1244 1bo4 (A) 25 148 21.00 0.0041 0.88 0.266281 -0.42
1130 1291 1ygh (A) 99 262 56.00 0 1 0.88668 -1.69
1131 1289 1qst (A) 49 208 66.00 0 1 1.02343 -1.68
1134 1235 3t9y (A) 6 111 28.00 0.72 0.62 0.231725 0.27
1142 1259 4yfj (A) 33 165 29.00 0.016 1 0.330446 0.07
1356 1460 4qns (A) 1356 1460 99.99 0 1 1.37557 -2.17
143 236 3ult (A) 6 100 29.00 0.0039 0.62 0.674933 -2.82
267 596 4r6f (A) 20 326 24.00 0.2 0.9 0.264696 0.87
781 1041 4u0r (A) 165 494 15.00 0.15 0.01 0.335893 -0.88
1132 1289 1z4r (A) 497 658 61.00 0 1 0.928729 -1.72
1133 1294 1ygh (A) 99 262 56.00 0 1 0.888454 -1.69
1134 1292 1qst (A) 49 208 66.00 0 1 1.02321 -1.68
1136 1258 1q2y (A) 1 119 16.00 0.47 0.69 0.295987 -0.47
1139 1243 2bei (A) 6 127 14.00 0.58 0.59 0.230726 -0.44
1145 1262 4yfj (A) 33 165 29.00 0.018 1 0.330281 0.07
1359 1463 4qns (A) 1356 1460 99.99 0 1 1.37543 -2.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

  • 4QNS:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5TPX:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Ring. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Sporozoite, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Female Gametocyte. Otto TD Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile gametocyte. PlasmoDB
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_127781)

Species Accession Gene Product
Arabidopsis thaliana AT3G54610   histone acetyltransferase GCN5
Babesia bovis BBOV_I003750   histone acetyltransferase
Brugia malayi Bm1_38035   acetyltransferase, GNAT family protein
Candida albicans CaO19.8324   bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase
Candida albicans CaO19.705   bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase
Caenorhabditis elegans CELE_Y47G6A.6   Protein PCAF-1
Cryptosporidium hominis Chro.30361   histone acetyltransferase
Cryptosporidium parvum cgd3_3190   GCN5 like acetylase + bromodomain
Dictyostelium discoideum DDB_G0283459   GCN5-related N-acetyltransferase
Drosophila melanogaster Dmel_CG4107   Gcn5 ortholog
Echinococcus granulosus EgrG_000900000   histone acetyltransferase KAT2B
Echinococcus granulosus EgrG_000899900   histone acetyltransferase KAT2B
Entamoeba histolytica EHI_140660   acetyltransferase, GNAT family
Echinococcus multilocularis EmuJ_000899900   gcn5proteinral control of amino acid synthesis
Giardia lamblia GL50803_10666   Histone acetyltransferase GCN5
Homo sapiens ENSG00000108773   K(lysine) acetyltransferase 2A
Homo sapiens ENSG00000114166   K(lysine) acetyltransferase 2B
Loa Loa (eye worm) LOAG_03313   acetyltransferase
Mus musculus ENSMUSG00000000708   K(lysine) acetyltransferase 2B
Mus musculus ENSMUSG00000020918   K(lysine) acetyltransferase 2A
Neospora caninum NCLIV_018170   Bromodomain containing protein, related
Neospora caninum NCLIV_008840   hypothetical protein
Oryza sativa 4348629   Os10g0415900
Plasmodium berghei PBANKA_0707300   histone acetyltransferase GCN5, putative
Plasmodium falciparum PF3D7_0823300   histone acetyltransferase GCN5
Plasmodium knowlesi PKNH_1317300   histone acetyltransferase GCN5, putative
Plasmodium vivax PVX_089200   histone acetyltransferase GCN5, putative
Plasmodium yoelii PY02679   histone acetyltransferase GCN5-related
Saccharomyces cerevisiae YGR252W   histone acetyltransferase GCN5
Schistosoma japonicum Sjp_0076690   ko:K06062 p300/CBP-associated factor, putative
Schistosoma mansoni Smp_070190   gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2
Schmidtea mediterranea mk4.001809.01   Putative gcn5
Schmidtea mediterranea mk4.001809.00  
Toxoplasma gondii TGME49_254555   histone lysine acetyltransferase GCN5-A
Toxoplasma gondii TGME49_243440   histone lysine acetyltransferase GCN5-B
Theileria parva TP01_0465   histone acetyltransferase Gcn5, putative
Trichomonas vaginalis TVAG_091650   cat eye syndrome critical region protein 2, cscr2, putative
Trichomonas vaginalis TVAG_340910   bromodomain-containing protein, putative

Essentiality

PF3D7_0823300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0707300 Plasmodium berghei Essential plasmo
TGME49_243440 Toxoplasma gondii Probably essential sidik
TGME49_254555 Toxoplasma gondii Probably essential sidik
TGME49_243440 Toxoplasma gondii Essentiality uncertain sidik
TGME49_254555 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3


Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens K(lysine) acetyltransferase 2A Compounds References
Saccharomyces cerevisiae histone acetyltransferase GCN5 Compounds References
Homo sapiens K(lysine) acetyltransferase 2B Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0047 0.2512 0.3483
0.0044 0.2512 1
0.0041 0.2512 1
0.004 0.2512 1
0.0047 0.2512 1
0.0047 0.2512 1
0.0624 0.2563 1
0.0089 0.2575 1
0.0089 0.2575 1
0.032 0.258 1
0.0044 0.2512 1
0.0164 0.261 1
0.0252 0.2578 1
0.032 0.258 1
0.0078 0.2533 1
0.027 0.256 1
0.015 0.2686 0.4187
0.0624 0.2563 1
0.0081 0.2504 1
0.0206 0.2509 1
0.0032 0.2512 0.3215
0.0047 0.2508 0.5
0.0083 0.2582 1
0.0081 0.2504 1
0.0047 0.2512 1
0.0362 0.2596 1
0.0047 0.2512 1
0.0004 0.5 0.5
0.0047 0.2515 1
0.0029 0.2513 1
0.0235 0.2528 1
0.008 0.2512 1
0.0116 0.2512 1
0.2163 0.2667 0.549
0.0042 0.2512 1
0.0047 0.2512 1
0.0362 0.2617 1
0.0196 0.2617 1
0.0047 0.2512 1
0.0079 0.2512 0.5615
0.0042 0.2512 1
0.0047 0.2512 1
0.0039 0.2515 1
0.0045 0.2512 1
0.0124 0.2556 1
0.0295 0.2584 1
0.0129 0.2627 1
0.0399 0.2607 1
0.0084 0.2512 1
0.0076 0.2512 1
0.0224 0.2517 0.7048
0.0047 0.2515 1
0.0117 0.2512 1
0.0078 0.2553 1
0.0143 0.2626 0.6138
0.0045 0.2512 1
0.2163 0.2667 0.549
0.0087 0.2512 1
0.004 0.2512 1
0.0044 0.2512 1
0.0116 0.2527 1
0.0003 0.5 0.5
0.054 0.2612 1
0.0044 0.2512 0.3483
0.0041 0.2515 1
0.0263 0.2622 0.686
0.0084 0.257 1
0.0047 0.2512 1
0.0047 0.2541 1
0.0243 0.2633 1
0.0083 0.2511 1
0.0086 0.2573 0.9355
0.0047 0.2512 1
0.0492 0.2632 1
0.0131 0.2608 1
0.0047 0.2512 1
0.0082 0.2559 1
0.0635 0.2648 1
0.0149 0.2755 0.606
0.0086 0.2572 1
0.0122 0.2572 1
0.0579 0.2586 1
0.008 0.2506 0.5
0.0047 0.2512 1
0.0032 0.2525 1
0.0198 0.2627 1
0.0047 0.2515 1
0.0168198 0.352469 0.5
0.0039 0.2515 1
0.0436 0.2579 1
0.008 0.2519 1
0.004 0.2523 1
0.0367 0.2558 1
0.0046 0.2512 1
0.0042 0.2512 1
0.0254 0.252 1
0.0119 0.2535 1
0.0136 0.2612 1
0.0091 0.2508 1
0.004 0.2523 1
0.004 0.2523 1
0.0043 0.2512 1
0.0143 0.2626 0.6138
0.025 0.2501 1
0.0047 0.2621 1
0.0045 0.2512 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0823300 (Plasmodium falciparum), histone acetyltransferase GCN5
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