Detailed view for Sjp_0012650

Basic information

TDR Targets ID: 967388
Schistosoma japonicum, ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.7867 | Length (AA): 1267 | MW (Da): 142212 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 4

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00027   Cyclic nucleotide-binding domain
PF00520   Ion transport protein
PF13646   HEAT repeats

Gene Ontology

Mouse over links to read term descriptions.
GO:0019135   deoxyhypusine monooxygenase activity  
GO:0016020   membrane  
GO:0005488   binding  
GO:0005249   voltage-gated potassium channel activity  
GO:0005216   ion channel activity  
GO:0055085   transmembrane transport  
GO:0008612   peptidyl-lysine modification to hypusine  
GO:0006813   potassium ion transport  
GO:0006811   ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
459 504 3kcc (B) 24 73 48.00 0.00035 0.71 0.375635 1.24
772 1266 3gq2 (A) 27 518 13.00 0 0.94 0.358895 0.59
911 1252 4d4z (A) 0 283 40.00 0 1 0.644942 -0.89
971 1265 3l6y (A) 379 748 16.00 0 0.91 0.297917 0.29
1199 1262 5d08 (A) 292 356 22.00 0.96 0.09 0.314353 -0.69

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128858)

Species Accession Gene Product
Arabidopsis thaliana AT4G22200   potassium channel AKT2/3
Brugia malayi Bm1_21880   Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog
Caenorhabditis elegans CELE_C30D11.1   Protein UNC-103, isoform A
Drosophila melanogaster Dmel_CG3182   seizure
Echinococcus granulosus EgrG_000637800   potassium voltage gated channel subfamily H
Echinococcus multilocularis EmuJ_000637800   potassium voltage gated channel subfamily H
Homo sapiens ENSG00000055118   potassium voltage-gated channel, subfamily H (eag-related), member 2
Homo sapiens ENSG00000184611   potassium voltage-gated channel, subfamily H (eag-related), member 7
Homo sapiens ENSG00000173826   potassium voltage-gated channel, subfamily H (eag-related), member 6
Loa Loa (eye worm) LOAG_09771   voltage and ligand gated potassium channel
Loa Loa (eye worm) LOAG_15459   hypothetical protein
Mus musculus ensembl-mmu:ENSMUSG00000001901   potassium voltage-gated channel, subfamily H (eag-related), member 6
Mus musculus 170738   potassium voltage-gated channel, subfamily H (eag-related), member 7
Mus musculus ENSMUSG00000038319   potassium voltage-gated channel, subfamily H (eag-related), member 2
Oryza sativa 4325143   Os01g0756700
Oryza sativa 4328864   Os02g0245800
Schistosoma japonicum Sjp_0205190   Potassium voltage-gated channel subfamily H member 2, putative
Schistosoma japonicum Sjp_0012650   ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative
Schistosoma japonicum Sjp_0029230   ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative
Schistosoma mansoni Smp_152350   voltage-gated potassium channel
Schistosoma mansoni Smp_161140   voltage-gated potassium channel
Schmidtea mediterranea mk4.001690.08  
Schmidtea mediterranea mk4.005037.02  
Schmidtea mediterranea mk4.028601.00  
Schmidtea mediterranea mk4.008564.00  
Schmidtea mediterranea mk4.001690.09  
Schmidtea mediterranea mk4.022343.01  
Schmidtea mediterranea mk4.001690.10  
Schmidtea mediterranea mk4.000405.00  
Schmidtea mediterranea mk4.000405.02  
Schmidtea mediterranea mk4.003213.00  
Trichomonas vaginalis TVAG_240490   voltage and ligand gated potassium channel, putative
Trichomonas vaginalis TVAG_038500   voltage and ligand gated potassium channel, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Cavia porcellus Potassium voltage-gated channel subfamily H member 2 Compounds References
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0012650 (Schistosoma japonicum), ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative
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