Detailed view for Sjp_0113200

Basic information

TDR Targets ID: 968082
Schistosoma japonicum, ko:K04440 c-Jun N-terminal kinase, putative
Source Database / ID:  Wormbase Parasite  

pI: 4.547 | Length (AA): 191 | MW (Da): 22316 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004707   MAP kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 177 2o2u (A) 225 400 64.00 0 1 1.57108 -0.67
1 179 2xrw (A) 171 364 62.00 0 1 1.71541 -0.97
2 82 2acx (A) 348 428 21.00 0.59 0.59 0.779816 -1.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129677)

Species Accession Gene Product
Brugia malayi Bm1_40555   Stress-activated protein kinase jnk-1
Caenorhabditis elegans CELE_B0478.1   Protein JNK-1, isoform A
Drosophila melanogaster Dmel_CG5680   basket
Echinococcus granulosus EgrG_000174000   c-Jun N-terminal kinases
Echinococcus multilocularis EmuJ_000174000   c Jun NH2 terminal kinase
Homo sapiens ENSG00000109339   mitogen-activated protein kinase 10
Homo sapiens ENSG00000107643   mitogen-activated protein kinase 8
Homo sapiens ENSG00000050748   mitogen-activated protein kinase 9
Loa Loa (eye worm) LOAG_02973   CMGC/MAPK/JNK protein kinase
Mus musculus ENSMUSG00000021936   mitogen-activated protein kinase 8
Mus musculus ENSMUSG00000046709   mitogen-activated protein kinase 10
Mus musculus ENSMUSG00000020366   mitogen-activated protein kinase 9
Schistosoma japonicum Sjp_0113200   ko:K04440 c-Jun N-terminal kinase, putative
Schistosoma japonicum Sjp_0129980   IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing
Schistosoma mansoni Smp_172240   serine/threonine protein kinase
Schmidtea mediterranea mk4.005863.01   Stress-activated protein kinase JNK

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus mitogen-activated protein kinase 8 Compounds References
Homo sapiens mitogen-activated protein kinase 10 Compounds References
Mus musculus mitogen-activated protein kinase 9 Compounds References
Homo sapiens mitogen-activated protein kinase 8 Compounds References
Rattus norvegicus c-Jun N-terminal kinase 3 Compounds References
Rattus norvegicus Mitogen-activated protein kinase 8 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0113200 (Schistosoma japonicum), ko:K04440 c-Jun N-terminal kinase, putative
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