Detailed view for Sjp_0086150

Basic information

TDR Targets ID: 968246
Schistosoma japonicum, Metabotropic glutamate receptor 7 precursor, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.6454 | Length (AA): 605 | MW (Da): 68779 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 8

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00003   7 transmembrane sweet-taste receptor of 3 GCPR
PF07562   Nine Cysteines Domain of family 3 GPCR

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0004930   G-protein coupled receptor activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
20 141 2e4u (A) 466 566 34.00 0.000064 0.78 0.170187 1.73
62 131 5kzn (A) 498 547 42.00 0.0026 0.99 0.204094 0.24
134 442 4or2 (A) 1101 843 26.00 0.000014 0.52 0.619789 0.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127276)

Species Accession Gene Product
Homo sapiens ENSG00000036828   calcium-sensing receptor
Mus musculus ENSMUSG00000051980   calcium-sensing receptor
Mus musculus ENSMUSG00000068999   vomeronasal 2, receptor 5
Mus musculus ENSMUSG00000092049   vomeronasal 2, receptor 4
Mus musculus ENSMUSG00000090581   vomeronasal 2, receptor 6
Mus musculus ENSMUSG00000043897   vomeronasal 2, receptor 2
Mus musculus ENSMUSG00000062200   vomeronasal 2, receptor 7
Mus musculus ENSMUSG00000091572   vomeronasal 2, receptor 3
Mus musculus ENSMUSG00000027824   vomeronasal 2, receptor 1
Schistosoma japonicum Sjp_0022600   Metabotropic glutamate receptor 7 precursor, putative
Schistosoma japonicum Sjp_0086150   Metabotropic glutamate receptor 7 precursor, putative
Schistosoma mansoni Smp_128940   metabotropic glutamate receptor

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens calcium-sensing receptor Compounds References
Rattus norvegicus Calcium sensing receptor Compounds References
Bos taurus Extracellular calcium-sensing receptor Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0086150 (Schistosoma japonicum), Metabotropic glutamate receptor 7 precursor, putative
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