Detailed view for Sjp_0303430

Basic information

TDR Targets ID: 968808
Schistosoma japonicum, ko:K01805 xylose isomerase [EC5.3.1.5], putative
Source Database / ID:  Wormbase Parasite  

pI: 8.2318 | Length (AA): 332 | MW (Da): 38107 | Paralog Number: 3

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02709   N-terminal domain of galactosyltransferase
PF13733   N-terminal region of glycosyl transferase group 7

Gene Ontology

Mouse over links to read term descriptions.
GO:0016757   transferase activity, transferring glycosyl groups  
GO:0005975   carbohydrate metabolic process  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130585)

Species Accession Gene Product
Brugia malayi Bm1_02765   Galactosyltransferase family protein
Drosophila melanogaster Dmel_CG8536   CG8536 gene product from transcript CG8536-RA
Echinococcus granulosus EgrG_000677850   Ribosomal protein L34a
Echinococcus granulosus EgrG_000925200   Metazoa galactosyltransferase
Echinococcus multilocularis EmuJ_000925200   Metazoa galactosyltransferase
Echinococcus multilocularis EmuJ_000677850   Ribosomal protein L34a
Echinococcus multilocularis EmuJ_000025500   Metazoa galactosyltransferase
Homo sapiens ENSG00000086062   UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Homo sapiens ENSG00000117411   UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
Loa Loa (eye worm) LOAG_08675   galactosyltransferase
Mus musculus ENSMUSG00000028413   UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Mus musculus ENSMUSG00000028541   UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
Schistosoma japonicum Sjp_0089080   Beta-1,4-galactosyltransferase 2, putative
Schistosoma japonicum Sjp_0303430   ko:K01805 xylose isomerase [EC5.3.1.5], putative
Schistosoma japonicum Sjp_0307070   ko:K02915 large subunit ribosomal protein L34e, putative
Schistosoma japonicum Sjp_0108110   expressed protein
Schistosoma mansoni Smp_021370   beta-14-galactosyltransferase
Schistosoma mansoni Smp_057840   beta-14-galactosyltransferase
Schmidtea mediterranea mk4.001916.02   Beta-1,4-N-acetylgalactosaminyltransferase bre-4
Schmidtea mediterranea mk4.040259.00  
Schmidtea mediterranea mk4.001210.01   Putative beta-1,4-galactosyltransferase
Schmidtea mediterranea mk4.025361.00  
Schmidtea mediterranea mk4.017668.00  
Schmidtea mediterranea mk4.024171.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 Compounds References
Bos taurus Beta-1,4-galactosyltransferase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Sjp_0303430 (Schistosoma japonicum), ko:K01805 xylose isomerase [EC5.3.1.5], putative
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