Detailed view for Sjp_0049310

Basic information

TDR Targets ID: 968921
Schistosoma japonicum, Lysosomal aspartic protease precursor, putative
Source Database / ID:  Wormbase Parasite  

pI: 5.668 | Length (AA): 765 | MW (Da): 87684 | Paralog Number: 4

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00026   Eukaryotic aspartyl protease

Gene Ontology

Mouse over links to read term descriptions.
GO:0004190   aspartic-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 86 4od9 (A) 11 96 44.00 0 0.79 0.554365 0.61
1 46 3oad (A) 16 61 46.00 0.0028 0.52 0.296609 2.18
177 271 4od9 (A) 3 94 45.00 0 0.72 0.538946 0.69
443 761 1pfz (C) 100 325 30.00 0 1 0.635139 0.04
459 686 1b5f (A) 13 238 37.00 0 1 0.700229 0.16
459 761 4auc (A) 15 322 31.00 0 1 0.823197 -0.95

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_140956)

Species Accession Gene Product
Schistosoma japonicum Sjp_0073720   Lysosomal aspartic protease precursor, putative
Schistosoma japonicum Sjp_0073700   Lysosomal aspartic protease precursor, putative
Schistosoma japonicum Sjp_0049300   IPR001461,Peptidase A1, pepsin;IPR009007,Peptidase aspartic, catalytic,domain-containing
Schistosoma japonicum Sjp_0049310   Lysosomal aspartic protease precursor, putative
Schistosoma japonicum Sjp_0073710   Cathepsin D precursor, putative
Schistosoma mansoni Smp_018800   subfamily A1A unassigned peptidase (A01 family)
Schistosoma mansoni Smp_136720   subfamily A1A unassigned peptidase (A01 family)
Schistosoma mansoni Smp_136830.1   subfamily A1A unassigned peptidase (A01 family)
Schistosoma mansoni Smp_132480   subfamily A1A unassigned peptidase (A01 family)
Schistosoma mansoni Smp_136830.2   subfamily A1A unassigned peptidase (A01 family)
Schistosoma mansoni Smp_136840   subfamily A1A unassigned peptidase (A01 family)
Schistosoma mansoni Smp_136820   subfamily A1A unassigned peptidase (A01 family)
Schistosoma mansoni Smp_132470   subfamily A1A unassigned peptidase (A01 family)

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Renin 280 aa 32.3% 235 aa Compounds References
Macaca mulatta Renin 406 aa 33.1% 326 aa Compounds References
Rhizopus microsporus var. chinensis Rhizopuspepsin 393 aa 27.7% 329 aa Compounds References
Bos taurus Cathepsin D 390 aa 32.5% 335 aa Compounds References
Callithrix jacchus Renin 400 aa 32.8% 326 aa Compounds References
Penicillium janthinellum Penicillopepsin 323 aa 24.8% 314 aa Compounds References
Rattus norvegicus Pepsinogen C 392 aa 27.8% 335 aa Compounds References
Macaca fascicularis Renin 406 aa 33.1% 326 aa Compounds References
Sus scrofa Pepsin A 385 aa 31.2% 324 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0049310 (Schistosoma japonicum), Lysosomal aspartic protease precursor, putative
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