pI: 4.7036 |
Length (AA): 140 |
MW (Da): 15483 |
Paralog Number:
7
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
13 | 51 | 4ku8 (A) | 316 | 353 | 50.00 | 0.0026 | 0.1 | 0.626776 | 1.36 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127599)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G20050 | protein phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein |
Babesia bovis | BBOV_I004690 | cGMP dependent protein kinase |
Brugia malayi | Bm1_37920 | Egg laying defective protein 4 |
Caenorhabditis elegans | CELE_F55A8.2 | Protein EGL-4, isoform F |
Caenorhabditis elegans | CELE_C09G4.2 | Protein PKG-2, isoform D |
Cryptosporidium hominis | Chro.80094 | cGMP-dependent protein kinase |
Cryptosporidium parvum | cgd8_750 | cyclic nucleotide (cGMP)-dependent protein kinase with 3 cNMP binding domains and a Ser/Thr kinase domain |
Drosophila melanogaster | Dmel_CG4839 | CG4839 gene product from transcript CG4839-RA |
Drosophila melanogaster | Dmel_CG10033 | foraging |
Drosophila melanogaster | Dmel_CG3324 | cGMP-dependent protein kinase 21D |
Echinococcus granulosus | EgrG_000452500 | cGMP dependent protein kinase 1 |
Echinococcus granulosus | EgrG_000158500 | cGMP dependent protein kinase |
Echinococcus granulosus | EgrG_000926500 | cGMP dependent protein kinase 1 |
Echinococcus multilocularis | EmuJ_000452500 | cGMP dependent protein kinase 1 |
Echinococcus multilocularis | EmuJ_000926500 | cGMP dependent protein kinase 1 |
Echinococcus multilocularis | EmuJ_000158500 | expressed conserved protein |
Homo sapiens | ENSG00000138669 | protein kinase, cGMP-dependent, type II |
Homo sapiens | ENSG00000185532 | protein kinase, cGMP-dependent, type I |
Loa Loa (eye worm) | LOAG_02880 | AGC/PKG protein kinase |
Mus musculus | ENSMUSG00000029334 | protein kinase, cGMP-dependent, type II |
Mus musculus | 19091 | protein kinase, cGMP-dependent, type I |
Mycobacterium ulcerans | MUL_2202 | hypothetical protein |
Neospora caninum | NCLIV_055260 | AGC kinase TgPKG1, putative |
Oryza sativa | 4329023 | Os02g0281000 |
Plasmodium berghei | PBANKA_1008200 | cGMP-dependent protein kinase |
Plasmodium falciparum | PF3D7_1436600 | cGMP-dependent protein kinase |
Plasmodium knowlesi | PKNH_0423200 | cGMP-dependent protein kinase, putative |
Plasmodium yoelii | PY02304 | cGMP-dependent protein kinase-related |
Schistosoma japonicum | Sjp_0046550 | expressed protein |
Schistosoma japonicum | Sjp_0098010 | cGMP-dependent protein kinase 2, putative |
Schistosoma japonicum | Sjp_0111040 | cGMP-dependent protein kinase, isozyme 1, putative |
Schistosoma japonicum | Sjp_0046560 | ko:K07376 protein kinase, cGMP-dependent, putative |
Schistosoma japonicum | Sjp_0122710 | cGMP-dependent protein kinase, isozyme 1, putative |
Schistosoma japonicum | Sjp_0104990 | cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B, putative |
Schistosoma japonicum | Sjp_0022170 | ko:K07376 protein kinase, cGMP-dependent, putative |
Schistosoma japonicum | Sjp_0130620 | cGMP-dependent protein kinase, isozyme 1, putative |
Schistosoma mansoni | Smp_123290 | serine/threonine protein kinase |
Schistosoma mansoni | Smp_168670 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.032121.00 | |
Schmidtea mediterranea | mk4.021434.00 | |
Schmidtea mediterranea | mk4.022194.00 | |
Schmidtea mediterranea | mk4.000154.02 | cGMP-dependent protein kinase 2 |
Schmidtea mediterranea | mk4.027115.00 | |
Schmidtea mediterranea | mk4.009551.02 | |
Schmidtea mediterranea | mk4.000154.06 | |
Schmidtea mediterranea | mk4.008740.03 | |
Schmidtea mediterranea | mk4.018099.00 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.020413.00 | |
Schmidtea mediterranea | mk4.011551.00 | |
Schmidtea mediterranea | mk4.020413.01 | |
Schmidtea mediterranea | mk4.009286.01 | |
Schmidtea mediterranea | mk4.027131.00 | cGMP-dependent protein kinase 1 |
Schmidtea mediterranea | mk4.014709.00 | cGMP-dependent protein kinase, isozyme 1 |
Schmidtea mediterranea | mk4.002475.04 | cGMP-dependent protein kinase egl-4 |
Schmidtea mediterranea | mk4.035287.00 | cGMP-dependent protein kinase,putative |
Schmidtea mediterranea | mk4.011327.00 | |
Toxoplasma gondii | TGME49_311360 | protein kinase G AGC kinase family member PKG |
Theileria parva | TP03_0511 | cGMP-dependent protein kinase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_C09G4.2 | Caenorhabditis elegans | sterile | wormbase |
TGME49_311360 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Plasmodium falciparum | cGMP-dependent protein kinase | Compounds | References |
Homo sapiens | protein kinase, cGMP-dependent, type I | Compounds | References |
Bos taurus | cGMP-dependent protein kinase 1 alpha | Compounds | References |
Eimeria tenella | cGMP-dependent protein kinase | Compounds | References |
Homo sapiens | protein kinase, cGMP-dependent, type II | Compounds | References |