Detailed view for Sjp_0100500

Basic information

TDR Targets ID: 970102
Schistosoma japonicum, ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.3429 | Length (AA): 1078 | MW (Da): 120390 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02196   Raf-like Ras-binding domain
PF07714   Protein tyrosine kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0007165   signal transduction  
GO:0006468   protein amino acid phosphorylation  

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
83 126 5vr3 (A) 58 100 24.00 0.1 0.04 0.245754 -0.95
211 277 2l05 (A) 148 216 28.00 0 1 0.38811 -0.3
220 275 2mse (D) 810 867 30.00 0.0000045 0.98 0.365896 -0.1
220 281 1c1y (B) 58 118 26.00 0.000000021 1 0.399467 -0.56
677 1076 2c0t (A) 108 486 28.00 0 1 0.494302 0.43
815 1076 5val (A) 446 710 67.00 0 1 0.985068 -0.82
817 1076 5ita (A) 448 710 56.00 0 1 0.761011 -0.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130459)

Species Accession Gene Product
Brugia malayi Bm1_40290   Raf kinase
Caenorhabditis elegans CELE_Y73B6A.5   Protein LIN-45, isoform A
Drosophila melanogaster Dmel_CG2845   pole hole
Echinococcus granulosus EgrG_001079900   raf serine:threonine protein kinase
Echinococcus multilocularis EmuJ_001079900   raf serine:threonine protein kinase
Homo sapiens ENSG00000132155   Raf-1 proto-oncogene, serine/threonine kinase
Homo sapiens ENSG00000157764   B-Raf proto-oncogene, serine/threonine kinase
Homo sapiens ENSG00000078061   A-Raf proto-oncogene, serine/threonine kinase
Loa Loa (eye worm) LOAG_09406   TKL/RAF/RAF protein kinase
Loa Loa (eye worm) LOAG_06145   raf kinase
Mus musculus ENSMUSG00000002413   Braf transforming gene
Mus musculus ENSMUSG00000000441   v-raf-leukemia viral oncogene 1
Mus musculus ENSMUSG00000001127   v-raf murine sarcoma 3611 viral oncogene homolog
Schistosoma japonicum Sjp_0100500   ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative
Schistosoma mansoni Smp_176990   serine/threonine protein kinase
Schmidtea mediterranea mk4.001123.06   Serine/threonine kinase
Schmidtea mediterranea mk4.001123.04   Raf homolog serine/threonine-protein kinase

Essentiality

Sjp_0100500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y73B6A.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y73B6A.5 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus Braf transforming gene Compounds References
Homo sapiens A-Raf proto-oncogene, serine/threonine kinase Compounds References
Homo sapiens B-Raf proto-oncogene, serine/threonine kinase Compounds References
Mus musculus v-raf-leukemia viral oncogene 1 Compounds References
Homo sapiens Raf-1 proto-oncogene, serine/threonine kinase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Jak1 protein 210 aa 27.1% 199 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0100500 (Schistosoma japonicum), ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative
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