Detailed view for Sjp_0075750

Basic information

TDR Targets ID: 970736
Schistosoma japonicum, IPR003644,Na-Ca exchanger/integrin-beta4,domain-containing
Source Database / ID:  Wormbase Parasite  

pI: 4.8017 | Length (AA): 52 | MW (Da): 5917 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 51 2klt (A) 566 610 33.00 0 0.04 1.01235 1.72

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128658)

Species Accession Gene Product
Arabidopsis thaliana AT2G47600   magnesium/proton exchanger
Brugia malayi Bm1_02560   Sodium/calcium exchanger protein
Caenorhabditis elegans CELE_Y113G7A.4   Protein NCX-1, isoform A
Caenorhabditis elegans CELE_ZC168.1   Protein NCX-3
Caenorhabditis elegans CELE_C10G8.5   Protein NCX-2, isoform C
Drosophila melanogaster Dmel_CG5685   Na/Ca-exchange protein
Echinococcus granulosus EgrG_000117900   sodium calcium exchanger
Echinococcus multilocularis EmuJ_000117900   sodium calcium exchanger
Homo sapiens 6546   solute carrier family 8 (sodium/calcium exchanger), member 1
Homo sapiens ENSG00000100678   solute carrier family 8 (sodium/calcium exchanger), member 3
Homo sapiens ENSG00000118160   solute carrier family 8 (sodium/calcium exchanger), member 2
Loa Loa (eye worm) LOAG_05506   hypothetical protein
Loa Loa (eye worm) LOAG_00664   solute carrier family 8
Mus musculus 20541   solute carrier family 8 (sodium/calcium exchanger), member 1
Mus musculus ENSMUSG00000030376   solute carrier family 8 (sodium/calcium exchanger), member 2
Mus musculus ENSMUSG00000079055   solute carrier family 8 (sodium/calcium exchanger), member 3
Oryza sativa 4330140   Os02g0644900
Oryza sativa 9268448   Os02g0644801
Oryza sativa 4351058   Os11g0660000
Schistosoma japonicum Sjp_0075760   ko:K05849 solute carrier family 8 (sodium/calcium exchanger), putative
Schistosoma japonicum Sjp_0053620   Sodium/calcium exchanger 1 precursor, putative
Schistosoma japonicum Sjp_0075750   IPR003644,Na-Ca exchanger/integrin-beta4,domain-containing
Schistosoma mansoni Smp_152830   sodium/calcium exchanger
Schmidtea mediterranea mk4.000323.00  
Schmidtea mediterranea mk4.001043.04  
Schmidtea mediterranea mk4.009186.00  
Schmidtea mediterranea mk4.004836.04  
Schmidtea mediterranea mk4.000874.06  
Schmidtea mediterranea mk4.000874.09  
Schmidtea mediterranea mk4.000874.07  
Schmidtea mediterranea mk4.008222.01  
Schmidtea mediterranea mk4.003870.01  
Schmidtea mediterranea mk4.000359.01  
Schmidtea mediterranea mk4.000323.02  
Schmidtea mediterranea mk4.001043.03  
Schmidtea mediterranea mk4.000874.04  
Schmidtea mediterranea mk4.000874.08  
Schmidtea mediterranea mk4.001043.02  

Essentiality

Sjp_0075750 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y113G7A.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_C10G8.5 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens solute carrier family 8 (sodium/calcium exchanger), member 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0075750 (Schistosoma japonicum), IPR003644,Na-Ca exchanger/integrin-beta4,domain-containing
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