pI: 9.6463 |
Length (AA): 394 |
MW (Da): 45319 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
18 | 380 | 3pfq (A) | 275 | 633 | 24.00 | 0 | 1 | 0.977964 | 0.68 |
41 | 358 | 4nst (A) | 722 | 1045 | 37.00 | 0 | 1 | 1.25986 | -0.36 |
42 | 341 | 3ddq (C) | 0 | 294 | 44.00 | 0 | 1 | 0.973959 | 0.32 |
43 | 337 | 3o0g (A) | 1 | 288 | 39.00 | 0 | 1 | 1.21794 | -0.65 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_132836)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_08135 | cell division protein kinase 10 |
Dictyostelium discoideum | DDB_G0268480 | CDK family protein kinase |
Drosophila melanogaster | Dmel_CG1362 | cdc2-related-kinase |
Echinococcus granulosus | EgrG_000724700 | cyclin dependent kinase 10 |
Echinococcus multilocularis | EmuJ_000724700 | cyclin dependent kinase 10 |
Homo sapiens | ENSG00000185324 | cyclin-dependent kinase 10 |
Loa Loa (eye worm) | LOAG_06017 | CMGC/CDK/CDK10 protein kinase |
Mus musculus | ENSMUSG00000033862 | cyclin-dependent kinase 10 |
Schistosoma japonicum | Sjp_0014710 | ko:K02449 cyclin-dependent kinase 10, putative |
Schistosoma mansoni | Smp_103950 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.004373.00 | Cyclin-dependent kinase 10 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 10 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 37.7% | 305 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 37.4% | 310 aa | Compounds | References |
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | 332 aa | 23.2% | 311 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 37.8% | 304 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 36.6% | 306 aa | Compounds | References |
Zea mays | Casein kinase II alpha | 332 aa | 22.9% | 328 aa | Compounds | References |
Rattus norvegicus | MAP kinase p38 alpha | 360 aa | 34.1% | 331 aa | Compounds | References |
Xenopus laevis | Aurora kinase B-A | 361 aa | 29.1% | 289 aa | Compounds | References |
Rattus norvegicus | Mitogen-activated protein kinase 1 | 358 aa | 33.7% | 309 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 42.1% | 195 aa | Compounds | References |