Detailed view for Sjp_0026520

Basic information

TDR Targets ID: 971061
Schistosoma japonicum, Alpha-1D adrenergic receptor, putative
Source Database / ID:  Wormbase Parasite  

pI: 10.0696 | Length (AA): 706 | MW (Da): 81874 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 4

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00001   7 transmembrane receptor (rhodopsin family)

Gene Ontology

Mouse over links to read term descriptions.
GO:0004977   melanocortin receptor activity  
GO:0016021   integral to membrane  
GO:0004930   G-protein coupled receptor activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
49 347 1l9h (B) 22 323 13.00 0.0000006 0.01 0.427013 0.34
67 344 4bvn (A) 44 351 7.00 0.00012 0 0.431226 -0.01
496 582 4iaq (A) 1104 384 56.00 0 0.21 0.431104 1.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128924)

Species Accession Gene Product
Caenorhabditis elegans CELE_F16D3.7   Protein SER-5
Caenorhabditis elegans CELE_C52B11.3   Protein DOP-4
Drosophila melanogaster Dmel_CG18741   Dopamine 1-like receptor 2
Homo sapiens ENSG00000171873   adrenoceptor alpha 1D
Homo sapiens 147   adrenoceptor alpha 1B
Homo sapiens ENSG00000113749   histamine receptor H2
Mus musculus ENSMUSG00000034987   histamine receptor H2
Mus musculus ENSMUSG00000050541   adrenergic receptor, alpha 1b
Mus musculus 11550   adrenergic receptor, alpha 1d
Schistosoma japonicum Sjp_0026520   Alpha-1D adrenergic receptor, putative
Schistosoma japonicum Sjp_0095180   ko:K04135 adrenergic receptor, alpha 1a, putative
Schistosoma mansoni Smp_150180   amine GPCR
Schmidtea mediterranea mk4.000742.09   Dopamine receptor 4
Schmidtea mediterranea mk4.029836.00  
Schmidtea mediterranea mk4.011371.00   Dopamine receptor 4
Schmidtea mediterranea mk4.003202.01   Dopamine receptor 4
Schmidtea mediterranea mk4.012659.00   Dopamine receptor 4
Schmidtea mediterranea mk4.028983.00   Putative g-protein coupled receptor
Schmidtea mediterranea mk4.031359.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus adrenergic receptor, alpha 1d Compounds References
Cavia porcellus Histamine H2 receptor Compounds References
Mesocricetus auratus Alpha-1b adrenergic receptor Compounds References
Rattus norvegicus Alpha-1d adrenergic receptor Compounds References
Homo sapiens adrenoceptor alpha 1B Compounds References
Homo sapiens adrenoceptor alpha 1D Compounds References
Homo sapiens histamine receptor H2 Compounds References
Rattus norvegicus Histamine H2 receptor Compounds References
Rattus norvegicus Alpha-1b adrenergic receptor Compounds References
Mus musculus adrenergic receptor, alpha 1b Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Macaca mulatta Gonadotropin-releasing hormone receptor 59 aa 32.1% 53 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0026520 (Schistosoma japonicum), Alpha-1D adrenergic receptor, putative
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