Detailed view for Sjp_0082170

Basic information

TDR Targets ID: 971445
Schistosoma japonicum, ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.7206 | Length (AA): 411 | MW (Da): 45842 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00001   7 transmembrane receptor (rhodopsin family)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0004930   G-protein coupled receptor activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
65 399 3sn6 (R) 1151 298 35.00 0 1 0.726173 1.18
71 402 5v54 (A) 41 347 29.00 0 1 1.14086 0.06
84 255 5vbl (B) 34 221 29.00 0.00000000099 0.96 0.603812 0.95
164 195 1hll (A) 1 32 56.00 0.0005 0.07 0.453349 1.85
254 356 4m0m (A) 351 453 19.00 0 0.03 0.44232 -0.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133249)

Species Accession Gene Product
Caenorhabditis elegans CELE_C02D4.2   Protein SER-2, isoform B
Drosophila melanogaster Dmel_CG12073   5-hydroxytryptamine (serotonin) receptor 7
Drosophila melanogaster Dmel_CG7485   Octopamine-Tyramine receptor
Echinococcus granulosus EgrG_001171200   biogenic amine 5HT receptor
Echinococcus multilocularis EmuJ_001004000   serotonin receptor
Echinococcus multilocularis EmuJ_001171200   serotonin receptor
Homo sapiens 3350   5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
Loa Loa (eye worm) LOAG_15618   hypothetical protein
Loa Loa (eye worm) LOAG_12811   hypothetical protein
Mus musculus ENSMUSG00000021721   5-hydroxytryptamine (serotonin) receptor 1A
Schistosoma japonicum Sjp_0027610   Octopamine receptor, putative
Schistosoma japonicum Sjp_0082170   ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative
Schistosoma japonicum Sjp_0082160   expressed protein
Schistosoma mansoni Smp_126730   biogenic amine (5HT) receptor
Schmidtea mediterranea mk4.001585.00   5-hydroxytryptamine receptor 7
Schmidtea mediterranea mk4.017426.00  
Schmidtea mediterranea mk4.000982.03  
Schmidtea mediterranea mk4.004661.00   5-hydroxytryptamine receptor 7
Schmidtea mediterranea mk4.029325.00   Tyramine receptor Ser-2
Schmidtea mediterranea mk4.011858.01  
Schmidtea mediterranea mk4.022850.01  
Schmidtea mediterranea mk4.000826.00  
Schmidtea mediterranea mk4.005939.01   5-hydroxytryptamine receptor 7
Schmidtea mediterranea mk4.010622.03  
Schmidtea mediterranea mk4.013827.00   5-hydroxytryptamine receptor 7
Schmidtea mediterranea mk4.000354.16  
Schmidtea mediterranea mk4.007388.02   5-hydroxytryptamine receptor 7
Schmidtea mediterranea mk4.016304.00   Putative g-protein coupled receptor
Schmidtea mediterranea mk4.003220.00  
Schmidtea mediterranea mk4.011006.00   5-hydroxytryptamine receptor 7

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Compounds References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Compounds References
Mus musculus 5-hydroxytryptamine (serotonin) receptor 1A Compounds References
Cricetulus griseus 5-hydroxytryptamine receptor Compounds References
Chilo suppressalis TyR1 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Serotonin 1B/1D receptor 374 aa 36.2% 326 aa Compounds References
Chlorocebus aethiops Dopamine D3 receptor 400 aa 30.0% 350 aa Compounds References
Rattus norvegicus Serotonin 1f (5-HT1f) receptor 366 aa 32.9% 325 aa Compounds References
Rattus norvegicus Histamine H4 receptor 391 aa 24.9% 342 aa Compounds References
Cavia porcellus Serotonin 1d (5-HT1d) receptor 376 aa 35.1% 325 aa Compounds References
Bos taurus 5-hydroxytryptamine 1D receptor 119 aa 42.7% 96 aa Compounds References
Rattus norvegicus Serotonin 1 (5-HT1) receptor 366 aa 32.9% 325 aa Compounds References
Rattus norvegicus Serotonin 1d (5-HT1d) receptor 374 aa 36.2% 326 aa Compounds References
Cavia porcellus Histamine H4 receptor 389 aa 23.1% 360 aa Compounds References
Sus scrofa Delta opioid receptor 228 aa 26.2% 187 aa Compounds References
Gorilla gorilla Serotonin 1b (5-HT1b) receptor 390 aa 31.6% 354 aa Compounds References
Rattus norvegicus Serotonin 5b (5-HT5b) receptor 370 aa 29.8% 309 aa Compounds References
Sus scrofa Serotonin 1d (5-HT1d) receptor 291 aa 34.2% 284 aa Compounds References
Rattus norvegicus Serotonin 5a (5-HT5a) receptor 357 aa 29.0% 348 aa Compounds References
Cavia porcellus Mu opioid receptor 98 aa 37.1% 97 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0082170 (Schistosoma japonicum), ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative
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