Detailed view for Sjp_0005580

Basic information

TDR Targets ID: 971516
Schistosoma japonicum, IPR000175,Sodium:neurotransmitter symporter,domain-containing
Source Database / ID:  Wormbase Parasite  

pI: 6.056 | Length (AA): 51 | MW (Da): 5816 | Paralog Number: 7

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00209   Sodium:neurotransmitter symporter family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0005328   neurotransmitter:sodium symporter activity  
GO:0006836   neurotransmitter transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 49 5i6x (A) 281 329 45.00 0 0.2 1.2203 2.19
10 50 4us3 (A) 185 225 32.00 0.00000031 0.11 0.9103 2.3

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126944)

Species Accession Gene Product
Caenorhabditis elegans CELE_T03F7.1   Protein SNF-11
Drosophila melanogaster Dmel_CG1732   CG1732 gene product from transcript CG1732-RA
Echinococcus granulosus EgrG_000483400   sodium:chloride dependent neurotransmitter
Echinococcus multilocularis EmuJ_000483400   sodium:chloride dependent neurotransmitter
Homo sapiens 6538   solute carrier family 6 (neurotransmitter transporter), member 11
Homo sapiens ENSG00000130821   solute carrier family 6 (neurotransmitter transporter), member 8
Homo sapiens 102725373   sodium- and chloride-dependent creatine transporter 1-like
Homo sapiens ENSG00000131389   solute carrier family 6 (neurotransmitter transporter), member 6
Homo sapiens ENSG00000157103   solute carrier family 6 (neurotransmitter transporter), member 1
Homo sapiens ENSG00000111181   solute carrier family 6 (neurotransmitter transporter), member 12
Homo sapiens ENSG00000010379   solute carrier family 6 (neurotransmitter transporter), member 13
Loa Loa (eye worm) LOAG_12882   hypothetical protein
Loa Loa (eye worm) LOAG_09225   hypothetical protein
Mus musculus ensembl-mmu:ENSMUSG00000030109   solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
Mus musculus ENSMUSG00000030310   solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Mus musculus ENSMUSG00000030307   solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Mus musculus ENSMUSG00000030096   solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Mus musculus ENSMUSG00000030108   solute carrier family 6 (neurotransmitter transporter, GABA), member 13
Mus musculus ENSMUSG00000019558   solute carrier family 6 (neurotransmitter transporter, creatine), member 8
Schistosoma japonicum Sjp_0005600   IPR000175,Sodium:neurotransmitter symporter,domain-containing
Schistosoma japonicum Sjp_0110600   IPR000175,Sodium:neurotransmitter symporter,domain-containing
Schistosoma japonicum Sjp_0005590   Sodium- and chloride-dependent GABA transporter 3, putative
Schistosoma japonicum Sjp_0039520   ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative
Schistosoma japonicum Sjp_0039510   Sodium- and chloride-dependent GABA transporter 2, putative
Schistosoma japonicum Sjp_0005570   Sodium- and chloride-dependent creatine transporter 1, putative
Schistosoma japonicum Sjp_0050310   ko:K10420 dynein light chain Tctex-type 1, putative
Schistosoma japonicum Sjp_0005580   IPR000175,Sodium:neurotransmitter symporter,domain-containing
Schistosoma mansoni Smp_160360   sodium/chloride dependent neurotransmitter transporter
Schistosoma mansoni Smp_078930   sodium/chloride dependent neurotransmitter transporter
Schistosoma mansoni Smp_143800   sodium/chloride dependent neurotransmitter transporter
Schmidtea mediterranea mk4.015951.01   Sodium- and chloride-dependent GABA transporter 1
Schmidtea mediterranea mk4.000843.11  
Schmidtea mediterranea mk4.000233.08  
Schmidtea mediterranea mk4.000843.10   Transporter
Schmidtea mediterranea mk4.000455.05   Transporter
Schmidtea mediterranea mk4.004288.01   Sodium-dependent serotonin transporter
Schmidtea mediterranea mk4.045756.00   Sodium- and chloride-dependent GABA transporter 1
Schmidtea mediterranea mk4.011457.01  
Schmidtea mediterranea mk4.000714.02  
Schmidtea mediterranea mk4.021993.02   Sodium- and chloride-dependent GABA transporter 1
Schmidtea mediterranea mk4.021993.01  
Schmidtea mediterranea mk4.045756.01  
Schmidtea mediterranea mk4.001225.10  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus GABA transporter Compounds References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 13 Compounds References
Mus musculus solute carrier family 6 (neurotransmitter transporter, GABA), member 13 Compounds References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 1 Compounds References
Mus musculus solute carrier family 6 (neurotransmitter transporter, GABA), member 1 Compounds References
Rattus norvegicus GABA transporter 2 Compounds References
Mus musculus solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 Compounds References
Rattus norvegicus GABA transporter 1 Compounds References
Rattus norvegicus Creatine transporter Compounds References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 11 Compounds References
Rattus norvegicus Isoleucyl-tRNA synthetase Compounds References
Mus musculus solute carrier family 6 (neurotransmitter transporter, GABA), member 11 Compounds References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 12 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0005580 (Schistosoma japonicum), IPR000175,Sodium:neurotransmitter symporter,domain-containing
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