Detailed view for Sjp_0201750

Basic information

TDR Targets ID: 971881
Schistosoma japonicum, ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.3804 | Length (AA): 706 | MW (Da): 77400 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134863)

Species Accession Gene Product
Brugia malayi Bm1_35225   Serine/threonine-protein kinase Pim-3
Brugia malayi Bm1_41540   Protein kinase domain containing protein
Caenorhabditis elegans CELE_F45H7.4   Protein PRK-2
Echinococcus granulosus EgrG_000197100   proto oncogene serine:threonine protein kinase
Echinococcus multilocularis EmuJ_000197100   proto oncogene serine:threonine protein kinase
Homo sapiens ENSG00000198355   Pim-3 proto-oncogene, serine/threonine kinase
Homo sapiens ENSG00000137193   Pim-1 proto-oncogene, serine/threonine kinase
Loa Loa (eye worm) LOAG_00334   CAMK/PIM protein kinase
Loa Loa (eye worm) LOAG_13501   CAMK/PIM protein kinase
Mus musculus 18712   proviral integration site 1
Mus musculus ENSMUSG00000035828   proviral integration site 3
Onchocerca volvulus OVOC5800   Serine\/threonine protein kinase homolog
Schistosoma japonicum Sjp_0201750   ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative
Schistosoma mansoni Smp_090890   serine/threonine protein kinase
Schmidtea mediterranea mk4.016302.01   Pim-2
Schmidtea mediterranea mk4.004631.00   Pim-3
Schmidtea mediterranea mk4.000422.04  
Schmidtea mediterranea mk4.000411.01  
Schmidtea mediterranea mk4.000985.00   Pim-1
Schmidtea mediterranea mk4.007368.00   Serine/threonine protein kinase
Schmidtea mediterranea mk4.017988.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Serine/threonine-protein kinase pim-3 Compounds References
Homo sapiens Pim-3 proto-oncogene, serine/threonine kinase Compounds References
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 25.6% 293 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 24.3% 296 aa Compounds References
Patiria pectinifera Cdc2 300 aa 27.0% 296 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 25.3% 324 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Sjp_0201750 (Schistosoma japonicum), ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative
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