Detailed view for Sjp_0025290

Basic information

TDR Targets ID: 972038
Schistosoma japonicum, ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.6168 | Length (AA): 409 | MW (Da): 47081 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 2

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00017   SH2 domain
PF07714   Protein tyrosine kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004672   protein kinase activity  
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 352 2fo0 (A) 146 526 34.00 0 1 1.12674 0.19
6 48 2c9w (A) 49 90 36.00 0 0.57 0.556992 -0.78
85 395 3hzt (A) 79 379 21.00 0 0.83 0.874055 0.44
86 398 5dvr (A) 55 357 22.00 0 0.95 0.872957 0.52
108 322 4hcu (A) 388 596 53.00 0 1 1.17706 -0.68

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129320)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG8049   Btk family kinase at 29A
Echinococcus granulosus EgrG_000256700   tyrosine protein kinase Btk29A
Echinococcus multilocularis EmuJ_000256700   tyrosine protein kinase Btk29A
Homo sapiens ENSG00000135605   tec protein tyrosine kinase
Homo sapiens ENSG00000102010   BMX non-receptor tyrosine kinase
Homo sapiens ENSG00000113263   IL2-inducible T-cell kinase
Homo sapiens ENSG00000074966   TXK tyrosine kinase
Homo sapiens ENSG00000010671   Bruton agammaglobulinemia tyrosine kinase
Mus musculus ENSMUSG00000031264   Bruton agammaglobulinemia tyrosine kinase
Mus musculus ENSMUSG00000020395   IL2 inducible T cell kinase
Mus musculus ENSMUSG00000031377   BMX non-receptor tyrosine kinase
Mus musculus ENSMUSG00000029217   tec protein tyrosine kinase
Mus musculus ENSMUSG00000054892   TXK tyrosine kinase
Schistosoma japonicum Sjp_0025290   ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative
Schistosoma japonicum Sjp_0069850   Tyrosine-protein kinase BTK, putative
Schistosoma mansoni Smp_124850   tyrosine kinase
Schmidtea mediterranea mk4.000175.16  
Schmidtea mediterranea mk4.027541.00   Tyrosine-protein kinase Btk29A
Schmidtea mediterranea mk4.049811.00   Tyrosine-protein kinase Btk29A

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens TXK tyrosine kinase Compounds References
Homo sapiens BMX non-receptor tyrosine kinase Compounds References
Homo sapiens IL2-inducible T-cell kinase Compounds References
Mus musculus BMX non-receptor tyrosine kinase Compounds References
Homo sapiens tec protein tyrosine kinase Compounds References
Mus musculus Bruton agammaglobulinemia tyrosine kinase Compounds References
Homo sapiens Bruton agammaglobulinemia tyrosine kinase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Jak1 protein 210 aa 33.5% 188 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 30.4% 158 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0025290 (Schistosoma japonicum), ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative
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