pI: 4.5439 |
Length (AA): 351 |
MW (Da): 39229 |
Paralog Number:
4
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 315 | 4wzi (B) | 184 | 653 | 37.00 | 0 | 0.94 | 0.694086 | 0.98 |
16 | 317 | 2qyk (A) | 327 | 621 | 20.00 | 0 | 0.49 | 1.04776 | -0.56 |
91 | 174 | 2mqa (A) | 37 | 130 | 32.00 | 0.92 | 0.42 | 0.5878 | -1.02 |
158 | 315 | 3g58 (A) | 454 | 573 | 44.00 | 0.000000000027 | 0.9 | 0.630229 | 0.35 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128242)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_53400 | Probable 3',5'-cyclic phosphodiesterase R153.1, putative |
Caenorhabditis elegans | CELE_R153.1 | Protein PDE-4, isoform F |
Cryptosporidium hominis | Chro.60068 | hypothetical protein |
Cryptosporidium parvum | cgd6_500 | membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein |
Drosophila melanogaster | Dmel_CG32498 | dunce |
Echinococcus granulosus | EgrG_000643700 | cAMP specific 3'5' cyclic phosphodiesterase |
Echinococcus granulosus | EgrG_000162200 | cAMP specific 3'5' cyclic phosphodiesterase |
Echinococcus granulosus | EgrG_000162300 | cAMP specific 3'5' cyclic phosphodiesterase |
Echinococcus multilocularis | EmuJ_000643700 | cAMP specific 3',5' cyclic phosphodiesterase |
Echinococcus multilocularis | EmuJ_000162200 | cAMP specific 3',5' cyclic phosphodiesterase |
Echinococcus multilocularis | EmuJ_000162300 | cAMP specific 3',5' cyclic phosphodiesterase |
Giardia lamblia | GL50803_14058 | CAMP-specific 3,5-cyclic phosphodiesterase 4B |
Homo sapiens | ENSG00000065989 | phosphodiesterase 4A, cAMP-specific |
Homo sapiens | ENSG00000184588 | phosphodiesterase 4B, cAMP-specific |
Homo sapiens | ENSG00000113448 | phosphodiesterase 4D, cAMP-specific |
Homo sapiens | ENSG00000105650 | phosphodiesterase 4C, cAMP-specific |
Loa Loa (eye worm) | LOAG_07841 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15725 | cyclic AMP specific phosphodiesterase PDE4D5A |
Mus musculus | ENSMUSG00000031842 | phosphodiesterase 4C, cAMP specific |
Mus musculus | ENSMUSG00000032177 | phosphodiesterase 4A, cAMP specific |
Mus musculus | 238871 | phosphodiesterase 4D, cAMP specific |
Mus musculus | ENSMUSG00000028525 | phosphodiesterase 4B, cAMP specific |
Neospora caninum | NCLIV_030330 | cAMP-specific phosphodiesterase, putative |
Schistosoma japonicum | Sjp_0079570 | IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing |
Schistosoma japonicum | Sjp_0111880 | cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative |
Schistosoma japonicum | Sjp_0072560 | cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative |
Schistosoma japonicum | Sjp_0121960 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative |
Schistosoma japonicum | Sjp_0107930 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative |
Schistosoma mansoni | Smp_134140 | camp-specific 35-cyclic phosphodiesterase |
Schmidtea mediterranea | mk4.017180.00 | |
Schmidtea mediterranea | mk4.017180.01 | |
Schmidtea mediterranea | mk4.008328.01 | Probable 3',5'-cyclic phosphodiesterase pde-4 |
Schmidtea mediterranea | mk4.006977.01 | |
Schmidtea mediterranea | mk4.011281.01 | Probable 3',5'-cyclic phosphodiesterase pde-4 |
Schmidtea mediterranea | mk4.011369.00 | |
Schmidtea mediterranea | mk4.056175.00 | Probable 3',5'-cyclic phosphodiesterase pde-4 |
Schmidtea mediterranea | mk4.023548.01 | Probable 3',5'-cyclic phosphodiesterase pde-4 |
Schmidtea mediterranea | mk4.011369.01 | Probable 3',5'-cyclic phosphodiesterase pde-4 |
Schmidtea mediterranea | mk4.000577.06 | Probable 3',5'-cyclic phosphodiesterase pde-4 |
Schmidtea mediterranea | mk4.003650.00 | Probable 3',5'-cyclic phosphodiesterase pde-4 |
Schmidtea mediterranea | mk4.002563.07 | Probable 3',5'-cyclic phosphodiesterase pde-4 |
Schmidtea mediterranea | mk4.010659.00 | |
Schmidtea mediterranea | mk4.023993.00 | |
Schmidtea mediterranea | mk4.023548.00 | |
Toxoplasma gondii | TGME49_229405 | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_229405 | Toxoplasma gondii | Essentiality uncertain | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | Phosphodiesterase 4 | Compounds | References |
Cavia porcellus | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Compounds | References |
Mus musculus | phosphodiesterase 4D, cAMP specific | Compounds | References |
Sus scrofa | Phosphodiesterase 4A | Compounds | References |
Homo sapiens | phosphodiesterase 4B, cAMP-specific | Compounds | References |
Homo sapiens | phosphodiesterase 4D, cAMP-specific | Compounds | References |
Mus musculus | phosphodiesterase 4C, cAMP specific | Compounds | References |
Mus musculus | phosphodiesterase 4B, cAMP specific | Compounds | References |
Mus musculus | phosphodiesterase 4A, cAMP specific | Compounds | References |
Rattus norvegicus | Phosphodiesterase 4D | Compounds | References |
Rattus norvegicus | Phosphodiesterase 4B | Compounds | References |
Homo sapiens | phosphodiesterase 4C, cAMP-specific | Compounds | References |
Homo sapiens | phosphodiesterase 4A, cAMP-specific | Compounds | References |