Detailed view for Sjp_0091490

Basic information

TDR Targets ID: 972410
Schistosoma japonicum, Protein kinase C alpha type, putative
Source Database / ID:  Wormbase Parasite  

pI: 5.623 | Length (AA): 152 | MW (Da): 17572 | Paralog Number: 4

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 145 3pfq (A) 496 638 54.00 0 1 1.51832 0.5
3 149 4ra4 (A) 493 665 54.00 0 1 1.47881 0.66
4 150 5li9 (A) 407 570 40.00 0 1 1.32781 0.67
13 103 5hu3 (A) 180 269 37.00 0 1 1.05115 -1.09
24 61 2jbp (J) 240 307 47.00 0.00025 0.91 0.733056 0.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129482)

Species Accession Gene Product
Brugia malayi Bm1_31105   Protein kinase c protein 2
Candida albicans CaO19.5901   protein kinase C similar to S. cerevisiae PKC1 (YBL105C)
Candida albicans CaO19.13322   protein kinase C similar to S. cerevisiae PKC1 (YBL105C)
Caenorhabditis elegans CELE_E01H11.1   Protein PKC-2, isoform D
Drosophila melanogaster Dmel_CG6622   Protein C kinase 53E
Drosophila melanogaster Dmel_CG6518   inactivation no afterpotential C
Echinococcus granulosus EgrG_001038500   RNA directed DNA polymerase
Echinococcus granulosus EgrG_000632400   Protein kinase C brain isozyme
Echinococcus granulosus EgrG_000696500   protein kinase C gamma type
Echinococcus multilocularis EmuJ_000696500   serine threonine protein kinase
Echinococcus multilocularis EmuJ_001038500   telomerase reverse transcriptase subunit
Echinococcus multilocularis EmuJ_001039300   RNA directed DNA polymerase
Echinococcus multilocularis EmuJ_000632400   Protein kinase C, brain isozyme
Homo sapiens ENSG00000166501   protein kinase C, beta
Homo sapiens ENSG00000126583   protein kinase C, gamma
Homo sapiens ENSG00000154229   protein kinase C, alpha
Loa Loa (eye worm) LOAG_06588   AGC/PKC/ALPHA protein kinase
Loa Loa (eye worm) LOAG_15630   hypothetical protein
Loa Loa (eye worm) LOAG_10111   hypothetical protein
Mus musculus ENSMUSG00000050965   protein kinase C, alpha
Mus musculus ENSMUSG00000078816   protein kinase C, gamma
Mus musculus ENSMUSG00000052889   protein kinase C, beta
Schistosoma japonicum Sjp_0131180   Protein kinase C gamma type, putative
Schistosoma japonicum Sjp_0317610   Protein kinase C alpha type, putative
Schistosoma japonicum Sjp_0091490   Protein kinase C alpha type, putative
Schistosoma japonicum Sjp_0088340   IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing
Schistosoma japonicum Sjp_0056860   Calcium-dependent protein kinase C, putative
Schistosoma mansoni Smp_176360   serine/threonine protein kinase
Schistosoma mansoni Smp_128480   serine/threonine protein kinase
Schmidtea mediterranea mk4.014385.00   Protein kinase C, brain isozyme
Schmidtea mediterranea mk4.005601.01   Protein kinase C, brain isozyme
Schmidtea mediterranea mk4.010109.02  
Schmidtea mediterranea mk4.002813.01  
Schmidtea mediterranea mk4.000718.00  
Schmidtea mediterranea mk4.022647.00   Protein kinase C, brain isozyme
Schmidtea mediterranea mk4.005601.00  
Schmidtea mediterranea mk4.000091.04   Protein kinase C-like 2
Schmidtea mediterranea mk4.008612.01   Protein kinase C-like 2

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Bos taurus Protein kinase C alpha Compounds References
Rattus norvegicus Protein kinase C alpha Compounds References
Mus musculus protein kinase C, alpha Compounds References
Homo sapiens protein kinase C, gamma Compounds References
Rattus norvegicus Protein kinase C beta Compounds References
Rattus norvegicus Protein kinase C gamma Compounds References
Homo sapiens protein kinase C, beta Compounds References
Homo sapiens protein kinase C, alpha Compounds References
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0091490 (Schistosoma japonicum), Protein kinase C alpha type, putative
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