Detailed view for Sjp_0300110

Basic information

TDR Targets ID: 972622
Schistosoma japonicum, ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative
Source Database / ID:  Wormbase Parasite  

pI: 5.4826 | Length (AA): 983 | MW (Da): 115132 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01433   Peptidase family M1 domain
PF11838   ERAP1-like C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0008237   metallopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127217)

Species Accession Gene Product
Brugia malayi Bm1_51650   Peptidase family M1 containing protein
Caenorhabditis elegans CELE_T07F10.1   Protein T07F10.1, isoform B
Dictyostelium discoideum DDB_G0273539   hypothetical protein
Dictyostelium discoideum DDB_G0273419   hypothetical protein
Drosophila melanogaster Dmel_CG31233   CG31233 gene product from transcript CG31233-RA
Drosophila melanogaster Dmel_CG31343   CG31343 gene product from transcript CG31343-RA
Drosophila melanogaster Dmel_CG11951   CG11951 gene product from transcript CG11951-RA
Drosophila melanogaster Dmel_CG11956   CG11956 gene product from transcript CG11956-RA
Drosophila melanogaster Dmel_CG31198   CG31198 gene product from transcript CG31198-RA
Drosophila melanogaster Dmel_CG14516   CG14516 gene product from transcript CG14516-RB
Drosophila melanogaster Dmel_CG8774   CG8774 gene product from transcript CG8774-RB
Drosophila melanogaster Dmel_CG31445   CG31445 gene product from transcript CG31445-RB
Drosophila melanogaster Dmel_CG8773   CG8773 gene product from transcript CG8773-RB
Drosophila melanogaster Dmel_CG32473   CG32473 gene product from transcript CG32473-RA
Echinococcus granulosus EgrG_001063900   aminopeptidase N
Echinococcus multilocularis EmuJ_001063900   aminopeptidase N
Homo sapiens ENSG00000166825   alanyl (membrane) aminopeptidase
Homo sapiens 2028   glutamyl aminopeptidase (aminopeptidase A)
Loa Loa (eye worm) LOAG_02562   peptidase family M1 containing protein
Loa Loa (eye worm) LOAG_11148   hypothetical protein
Loa Loa (eye worm) LOAG_11185   hypothetical protein
Mus musculus ENSMUSG00000028024   glutamyl aminopeptidase
Mus musculus ENSMUSG00000039062   alanyl (membrane) aminopeptidase
Mus musculus 102635007   predicted gene, 32451
Onchocerca volvulus OVOC6851  
Schistosoma japonicum Sjp_0300110   ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative
Schmidtea mediterranea mk4.000938.08  
Schmidtea mediterranea mk4.020794.02  
Schmidtea mediterranea mk4.040739.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Sus scrofa Aminopeptidase N Compounds References
Mus musculus alanyl (membrane) aminopeptidase Compounds References
Homo sapiens alanyl (membrane) aminopeptidase Compounds References
Sus scrofa Aminopeptidase A Compounds References
Homo sapiens glutamyl aminopeptidase (aminopeptidase A) Compounds References
Rattus norvegicus Aminopeptidase N Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0300110 (Schistosoma japonicum), ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative
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