Detailed view for Sjp_0303660

Basic information

TDR Targets ID: 973058
Schistosoma japonicum, ko:K06172 anterior pharynx defective 1, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.9236 | Length (AA): 314 | MW (Da): 34728 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06105   Aph-1 protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0043085   positive regulation of catalytic activity  
GO:0016485   protein processing  

Metabolic Pathways

Notch signaling pathway (KEGG)
Alzheimer's disease (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130831)

Species Accession Gene Product
Arabidopsis thaliana AT2G31440   hypothetical protein
Brugia malayi Bm1_27555   gamma-secretase subunit aph-1
Caenorhabditis elegans CELE_VF36H2L.1   Protein APH-1
Dictyostelium discoideum DDB_G0267976   gamma-secretase subunit Aph-1
Drosophila melanogaster Dmel_CG2855   anterior pharynx defective 1
Echinococcus granulosus EgrG_000814500   gamma secretase subunit aph 1
Echinococcus multilocularis EmuJ_000814500   gamma secretase subunit aph 1
Homo sapiens ENSG00000117362   APH1A gamma secretase subunit
Homo sapiens ENSG00000138613   APH1B gamma secretase subunit
Loa Loa (eye worm) LOAG_02498   gamma-secretase subunit aph-1
Mus musculus ENSMUSG00000053040   anterior pharynx defective 1c homolog (C. elegans)
Mus musculus ENSMUSG00000015750   anterior pharynx defective 1a homolog (C. elegans)
Mus musculus ENSMUSG00000032375   anterior pharynx defective 1b homolog (C. elegans)
Oryza sativa 4328988   Os02g0272600
Schistosoma japonicum Sjp_0303660   ko:K06172 anterior pharynx defective 1, putative
Schistosoma mansoni Smp_050110   gamma-secretase subunit aph-1
Schmidtea mediterranea mk4.003938.01   Gamma-secretase subunit aph-1
Schmidtea mediterranea mk4.025650.00   Gamma-secretase subunit aph-1

Essentiality

Sjp_0303660 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_VF36H2L.1 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens APH1A gamma secretase subunit Compounds References
Homo sapiens APH1B gamma secretase subunit Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0303660 (Schistosoma japonicum), ko:K06172 anterior pharynx defective 1, putative
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