Detailed view for Sjp_0011570

Basic information

TDR Targets ID: 973312
Schistosoma japonicum, Myosin-XVIIIa, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.2159 | Length (AA): 1565 | MW (Da): 178665 | Paralog Number: 9

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 8

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00001   7 transmembrane receptor (rhodopsin family)
PF00063   Myosin head (motor domain)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016459   myosin complex  
GO:0016021   integral to membrane  
GO:0003777   microtubule motor activity  
GO:0003774   motor activity  
GO:0051015   actin filament binding  
GO:0008017   microtubule binding  
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004930   G-protein coupled receptor activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  
GO:0007018   microtubule-based movement  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
165 214 2dls (A) 38 86 33.00 0.26 0.69 0.349069 0.43
171 215 2omj (A) 43 86 39.00 0.64 0.26 0.340872 0.65
268 808 1l2o (A) 71 543 24.00 0 1 0.283908 0.77
316 1242 3a6p (A) 136 1122 10.00 0 0.83 0.601711 0.55
610 1563 1u6g (C) 92 1043 12.00 0 0.82 0.609974 0.78
873 1187 1l9h (B) 27 323 14.00 0 0.07 0.104507 0.35
985 1191 4uhr (A) 95 309 28.00 0.25 0.14 -0.0161471 1.81

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_138837)

Species Accession Gene Product
Echinococcus granulosus EgrG_000633100   rhodopsin orphan GPCR
Echinococcus granulosus EgrG_001036800   myosin xviiia
Echinococcus multilocularis EmuJ_001036800   myosin xviiia
Echinococcus multilocularis EmuJ_000633100   rhodopsin orphan GPCR
Schistosoma japonicum Sjp_0011570   Myosin-XVIIIa, putative
Schistosoma japonicum Sjp_0011560   IPR000276,Rhodopsin-like GPCR superfamily,domain-containing
Schistosoma japonicum Sjp_0053400   IPR000276,Rhodopsin-like GPCR superfamily,domain-containing
Schistosoma japonicum Sjp_0094600   IPR000276,Rhodopsin-like GPCR superfamily,domain-containing
Schistosoma japonicum Sjp_0045160   IPR000276,Rhodopsin-like GPCR superfamily,domain-containing
Schistosoma japonicum Sjp_0053410   IPR000276,Rhodopsin-like GPCR superfamily,domain-containing
Schistosoma japonicum Sjp_0075680   IPR000276,Rhodopsin-like GPCR superfamily,domain-containing
Schistosoma japonicum Sjp_0069520   hypothetical protein
Schistosoma japonicum Sjp_0056590   IPR000276,Rhodopsin-like GPCR superfamily,domain-containing
Schistosoma japonicum Sjp_0056600   IPR000276,Rhodopsin-like GPCR superfamily,domain-containing
Schistosoma mansoni Smp_084280   rhodopsin-like orphan GPCR
Schistosoma mansoni Smp_091950   rhodopsin-like orphan GPCR
Schistosoma mansoni Smp_083940   rhodopsin-like orphan GPCR
Schistosoma mansoni Smp_084290   hypothetical protein
Schistosoma mansoni Smp_177720   hypothetical protein
Schistosoma mansoni Smp_083950   hypothetical protein
Schistosoma mansoni Smp_084270   rhodopsin-like orphan GPCR
Schistosoma mansoni Smp_167870   rhodopsin-like orphan GPCR
Schistosoma mansoni Smp_172320   myosin xvIII
Schmidtea mediterranea mk4.007587.01  
Schmidtea mediterranea mk4.006472.00  
Schmidtea mediterranea mk4.027521.01  
Schmidtea mediterranea mk4.008510.02  
Schmidtea mediterranea mk4.001825.05  
Schmidtea mediterranea mk4.019969.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Purinergic receptor P2Y1 373 aa 22.4% 299 aa Compounds References
Rattus norvegicus Purinergic receptor P2Y12 343 aa 22.8% 325 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0011570 (Schistosoma japonicum), Myosin-XVIIIa, putative
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