Detailed view for Sjp_0089220

Basic information

TDR Targets ID: 973676
Schistosoma japonicum, ko:K07203 FKBP12-rapamycin complex-associated protein, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.9912 | Length (AA): 2249 | MW (Da): 251022 | Paralog Number: 3

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00454   Phosphatidylinositol 3- and 4-kinase
PF02259   FAT domain
PF02260   FATC domain
PF11865   Domain of unknown function (DUF3385)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016301   kinase activity  
GO:0005515   protein binding  
GO:0005488   binding  
GO:0004674   protein serine/threonine kinase activity  

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 59 1te4 (A) 28 79 8.00 0.45 0.01 -0.118754 0.74
5 168 1b3u (A) 174 328 12.00 0.0074 0.22 0.115954 -0.33
22 738 2qmr (B) 67 870 10.00 0 0.99 0.40595 0.21
48 217 2qk1 (A) 342 511 9.00 0 0.08 0.0856228 -0.31
273 352 4x8w (H) 1 303 66.00 0 0.21 -0.479413 3.43
475 674 2of3 (A) 659 857 16.00 0 1 0.374968 -0.95
479 684 4g3a (A) 23 230 17.00 0 0.97 0.310637 -0.65
1127 2248 5wby (B) 1398 2549 22.00 0 1 0.66511 0.52
1805 2035 2x6h (A) 699 939 20.00 0.0000068 0.94 0.312758 -0.38
2062 2174 2wwe (A) 0 1306 11.00 0.000013 0.01 0.119267 -0.4
2217 2248 2kio (A) 2 33 59.00 0.00000015 0.46 0.455235 1.73

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127212)

Species Accession Gene Product
Arabidopsis thaliana AT1G50030   serine/threonine-protein kinase TOR
Brugia malayi Bm1_48125   Phosphatidylinositol 3- and 4-kinase family protein
Candida albicans CaO19.9461   similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n
Candida albicans CaO19.1903   frameshifted from upstream TOR2 CDS (CaP19.1905)
Candida albicans CaO19.9459   frameshifted from upsteam TOR2 CDS (CaP19.9461)
Candida albicans CaO19.1905   similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n
Candida albicans CaO19.9830   similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in
Candida albicans CaO19.2290   similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in
Caenorhabditis elegans CELE_B0261.2   Protein LET-363, isoform A
Dictyostelium discoideum DDB_G0281569   FRAP subfamily protein kinase
Drosophila melanogaster Dmel_CG5092   Target of rapamycin
Echinococcus granulosus EgrG_000787900   FKBP12 rapamycin complex associated protein
Entamoeba histolytica EHI_155160   FKBP-rapamycin associated protein (FRAP), putative
Entamoeba histolytica EHI_169320   phosphatidylinositol3-kinaseTor2, putative
Echinococcus multilocularis EmuJ_000787900   FKBP12 rapamycin complex associated protein
Giardia lamblia GL50803_35180   GTOR
Homo sapiens ENSG00000198793   mechanistic target of rapamycin (serine/threonine kinase)
Leishmania braziliensis LbrM.20.3990   target of rapamycin (TOR) kinase 2, putative
Leishmania donovani LdBPK_366580.1   Phosphatidylinositol 3-kinase tor1
Leishmania donovani LdBPK_344160.1   Phosphatidylinositol 3-kinase tor2
Leishmania infantum LinJ.36.6580   target of rapamycin (TOR) kinase 1, putative
Leishmania infantum LinJ.34.4160   target of rapamycin (TOR) kinase 2, putative
Leishmania major LmjF.36.6320   target of rapamycin (TOR) kinase 1, putative
Leishmania major LmjF.34.4530   target of rapamycin (TOR) kinase 2, putative
Leishmania mexicana LmxM.33.4530   phosphatidylinositol 3-kinase (tor2)-like protein
Leishmania mexicana LmxM.36.6320   phosphatidylinositol 3 kinase, putative
Loa Loa (eye worm) LOAG_06798   phosphatidylinositol 3
Loa Loa (eye worm) LOAG_11192   hypothetical protein
Mus musculus ENSMUSG00000028991   mechanistic target of rapamycin (serine/threonine kinase)
Neospora caninum NCLIV_058910   Phosphatidylinositol 3-kinase tor2, related
Oryza sativa 4338174   Os05g0235300
Saccharomyces cerevisiae YJR066W   phosphatidylinositol kinase-related protein kinase TOR1
Saccharomyces cerevisiae YKL203C   phosphatidylinositol kinase-related protein kinase TOR2
Schistosoma japonicum Sjp_0134370   FKBP12-rapamycin complex-associated protein, putative
Schistosoma japonicum Sjp_0089220   ko:K07203 FKBP12-rapamycin complex-associated protein, putative
Schistosoma japonicum Sjp_0131090   FKBP12-rapamycin complex-associated protein, putative
Schistosoma japonicum Sjp_0215970   FKBP12-rapamycin complex-associated protein, putative
Schistosoma mansoni Smp_122910   ataxia telangiectasia mutated (atm)-related
Schmidtea mediterranea mk4.000497.09  
Schmidtea mediterranea mk4.000497.07  
Schmidtea mediterranea mk4.000497.08  
Schmidtea mediterranea mk4.000497.05   Tor-like protein
Trypanosoma brucei gambiense Tbg972.4.150   phosphatidylinositol 3-kinase tor, putative
Trypanosoma brucei gambiense Tbg972.10.10260   phosphatidylinositol 3 kinase, putative
Trypanosoma brucei Tb927.10.8420   Phosphatidylinositol 3-kinase tor1
Trypanosoma brucei Tb927.4.420   phosphatidylinositol 4-kinase, putative
Trypanosoma brucei Tb11.v5.0744   phosphatidylinositol 3-kinase tor, putative
Trypanosoma congolense TcIL3000_4_110   Phosphatidylinositol 3-kinase tor2
Trypanosoma congolense TcIL3000_10_7280   Phosphatidylinositol 3-kinase tor1
Trypanosoma cruzi TcCLB.510689.40   Phosphatidylinositol 3-kinase tor2
Trypanosoma cruzi TcCLB.508231.30   Phosphatidylinositol 3-kinase tor1
Toxoplasma gondii TGME49_316430   target of rapamycin (TOR), putative
Trichomonas vaginalis TVAG_346960   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_422770   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_163840   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_305430   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_271190   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_490020   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_069490   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_451890   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_445310   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_040340   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_232830   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_327580   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_235060   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_068860   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_359910   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_239190   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_412960   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_257180   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_087200   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_197350   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_405500   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_453520   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_125480   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_392220   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_212750   PIKK family atypical protein kinase

Essentiality

Sjp_0089220 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.420 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.420 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.4.420 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.420 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.8420 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.8420 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.8420 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.8420 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_B0261.2 Caenorhabditis elegans embryonic arrest wormbase
CELE_B0261.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_B0261.2 Caenorhabditis elegans larval arrest wormbase
YKL203C Saccharomyces cerevisiae inviable yeastgenome
TGME49_316430 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus mechanistic target of rapamycin (serine/threonine kinase) Compounds References
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Compounds References
Rattus norvegicus Serine/threonine-protein kinase mTOR Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Sjp_0089220 (Schistosoma japonicum), ko:K07203 FKBP12-rapamycin complex-associated protein, putative
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