Detailed view for Sjp_0217060

Basic information

TDR Targets ID: 973800
Schistosoma japonicum, ko:K02211 cyclin-dependent kinase 9, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.3166 | Length (AA): 421 | MW (Da): 48004 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

Transcriptional misregulation in cancer (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130531)

Species Accession Gene Product
Brugia malayi Bm1_20615   cyclin-dependent kinase 9
Candida albicans CaO19.11006   CDC2-related protein kinase
Candida albicans CaO19.3524   similar ot C terminus of S. cerevisiae SGV1 (YPR161C)
Caenorhabditis elegans CELE_M04D5.4   Protein CDK-9, isoform A
Caenorhabditis elegans CELE_H25P06.2   Protein CDK-9, isoform B
Drosophila melanogaster Dmel_CG5179   Cyclin-dependent kinase 9
Echinococcus granulosus EgrG_000627050   cyclin dependent kinase 9
Echinococcus granulosus EgrG_000596200   cyclin dependent kinase 9
Entamoeba histolytica EHI_108670   protein kinase domain containing protein
Echinococcus multilocularis EmuJ_000596200   cyclin dependent kinase 9
Echinococcus multilocularis EmuJ_000627050   cyclin dependent kinase 9
Homo sapiens ENSG00000136807   cyclin-dependent kinase 9
Loa Loa (eye worm) LOAG_13620   CMGC/CDK/CDK9 protein kinase
Mus musculus 107951   cyclin-dependent kinase 9 (CDC2-related kinase)
Saccharomyces cerevisiae YPR161C   Sgv1p
Schistosoma japonicum Sjp_0217060   ko:K02211 cyclin-dependent kinase 9, putative
Schistosoma japonicum Sjp_0025570   ko:K02211 cyclin-dependent kinase 9, putative
Schistosoma mansoni Smp_094760   serine/threonine protein kinase
Schistosoma mansoni Smp_003000   kinase
Schmidtea mediterranea mk4.012948.00  
Schmidtea mediterranea mk4.000003.28  
Schmidtea mediterranea mk4.009317.00  

Essentiality

Sjp_0217060 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_H25P06.2 Caenorhabditis elegans embryonic arrest wormbase
CELE_H25P06.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_H25P06.2 Caenorhabditis elegans larval arrest wormbase
CELE_H25P06.2 Caenorhabditis elegans slow growth wormbase
YPR161C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens cyclin-dependent kinase 9 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Cell division protein kinase 5 292 aa 41.0% 307 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 36.5% 304 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 34.1% 314 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 28.2% 312 aa Compounds References
Sus scrofa Glycogen synthase kinase 3 beta 420 aa 29.4% 337 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 40.1% 309 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 40.9% 306 aa Compounds References
Rattus norvegicus Glycogen synthase kinase-3 beta 420 aa 30.0% 337 aa Compounds References
Bos taurus Glycogen synthase kinase-3 beta splice variant X1 419 aa 29.7% 337 aa Compounds References
Xenopus laevis Aurora kinase B-B 368 aa 28.6% 301 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 38.1% 202 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 28.6% 301 aa Compounds References
Zea mays Casein kinase II alpha 332 aa 27.2% 309 aa Compounds References
Patiria pectinifera Cdc2 300 aa 39.6% 303 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0217060 (Schistosoma japonicum), ko:K02211 cyclin-dependent kinase 9, putative
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