Detailed view for Sjp_0034800

Basic information

TDR Targets ID: 973910
Schistosoma japonicum, Neuronal acetylcholine receptor subunit alpha-9-II precursor, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.5575 | Length (AA): 495 | MW (Da): 57574 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 4

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02931   Neurotransmitter-gated ion-channel ligand binding domain
PF02932   Neurotransmitter-gated ion-channel transmembrane region

Gene Ontology

Mouse over links to read term descriptions.
GO:0034220   transmembrane ion transport  
GO:0016021   integral to membrane  
GO:0005230   extracellular ligand-gated ion channel activity  
GO:0005216   ion channel activity  
GO:0004888   transmembrane receptor activity  
GO:0006811   ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
27 252 2wn9 (A) 3 207 17.00 0 1 0.58459 0.2
33 252 2bj0 (A) 2 203 23.00 0 1 0.608444 0.34
37 217 2bj0 (A) 6 167 33.00 0.0000018 0.82 0.506397 0.83

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_135157)

Species Accession Gene Product
Caenorhabditis elegans CELE_F27B3.2   Protein ACR-21
Homo sapiens ENSG00000174343   cholinergic receptor, nicotinic, alpha 9 (neuronal)
Mus musculus ENSMUSG00000029205   cholinergic receptor, nicotinic, alpha polypeptide 9
Schistosoma japonicum Sjp_0034800   Neuronal acetylcholine receptor subunit alpha-9-II precursor, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens cholinergic receptor, nicotinic, alpha 9 (neuronal) Compounds References
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-9 subunit Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Cavia porcellus Serotonin 3a (5-HT3a) receptor 490 aa 22.9% 458 aa Compounds References
Rattus norvegicus Nicotinic acetylcholine receptor alpha9/alpha10 447 aa 27.2% 463 aa Compounds References
Rattus norvegicus Nicotinic acetylcholine receptor alpha6/alpha3/beta2/beta3 464 aa 26.0% 458 aa Compounds References
Torpedo californica Acetylcholine receptor protein alpha chain 461 aa 24.9% 457 aa Compounds References
Rattus norvegicus Serotonin 3a (5-HT3a) receptor 483 aa 24.7% 457 aa Compounds References
Rattus norvegicus Serotonin 3 (5-HT3) receptor 483 aa 24.7% 457 aa Compounds References
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-10 subunit 447 aa 27.2% 463 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0034800 (Schistosoma japonicum), Neuronal acetylcholine receptor subunit alpha-9-II precursor, putative
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