Detailed view for Sjp_0302720

Basic information

TDR Targets ID: 973991
Schistosoma japonicum, Cathepsin D precursor, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.032 | Length (AA): 388 | MW (Da): 44031 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00026   Eukaryotic aspartyl protease

Gene Ontology

Mouse over links to read term descriptions.
GO:0004190   aspartic-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126885)

Species Accession Gene Product
Arabidopsis thaliana AT4G04460   aspartic proteinase A3
Arabidopsis thaliana AT1G11910   aspartic proteinase A1
Arabidopsis thaliana AT1G62290   aspartic proteinase A2
Babesia bovis BBOV_III003510   eukaryotic aspartyl protease family protein
Candida albicans CaO19.1891   vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C)
Candida albicans CaO19.9447   vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C)
Caenorhabditis elegans CELE_R12H7.2   Protein ASP-4
Caenorhabditis elegans CELE_H22K11.1   Protein ASP-3
Cryptosporidium hominis Chro.60437   aspartyl protease precursor
Cryptosporidium parvum cgd6_3820   membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain
Dictyostelium discoideum DDB_G0279411   cathepsin D
Drosophila melanogaster Dmel_CG17134   CG17134 gene product from transcript CG17134-RA
Drosophila melanogaster Dmel_CG13374   pepsinogen-like
Drosophila melanogaster Dmel_CG6508   CG6508 gene product from transcript CG6508-RA
Drosophila melanogaster Dmel_CG1548   CG1548 gene product from transcript CG1548-RA
Drosophila melanogaster Dmel_CG13095   beta-site APP-cleaving enzyme
Drosophila melanogaster Dmel_CG33128   CG33128 gene product from transcript CG33128-RA
Drosophila melanogaster Dmel_CG5863   CG5863 gene product from transcript CG5863-RA
Echinococcus granulosus EgrG_000970500   cathepsin d lysosomal aspartyl protease
Echinococcus multilocularis EmuJ_000970500   cathepsin d (lysosomal aspartyl protease)
Homo sapiens ENSG00000131400   napsin A aspartic peptidase
Homo sapiens ENSG00000117984   cathepsin D
Homo sapiens ENSG00000196188   cathepsin E
Homo sapiens ENSG00000143839   renin
Loa Loa (eye worm) LOAG_13316   aspartic protease BmAsp-2
Loa Loa (eye worm) LOAG_13198   hypothetical protein
Mus musculus 102643057   renin-1-like
Mus musculus ENSMUSG00000004552   cathepsin E
Mus musculus ENSMUSG00000070645   renin 1 structural
Mus musculus 19702   renin 2 tandem duplication of Ren1
Mus musculus ENSMUSG00000007891   cathepsin D
Mus musculus ENSMUSG00000002204   napsin A aspartic peptidase
Neospora caninum NCLIV_024980   Pepsinogen A1, related
Neospora caninum NCLIV_022920   Renin, related
Oryza sativa 4327861   Os01g0663400
Oryza sativa 9269561   Os12g0263800
Oryza sativa 4337744   Os05g0137400
Oryza sativa 4326588   Os01g0631900
Oryza sativa 4325154   Os01g0290000
Oryza sativa 4339639   Os05g0567100
Plasmodium berghei PBANKA_1034400   plasmepsin IV
Plasmodium berghei PBANKA_0409700   plasmepsin VI
Plasmodium falciparum PF3D7_0311700   plasmepsin VI
Plasmodium falciparum PF3D7_1407800   plasmepsin IV
Plasmodium falciparum PF3D7_1407900   plasmepsin I
Plasmodium falciparum PF3D7_1408000   plasmepsin II
Plasmodium knowlesi PKNH_1350300   plasmepsin IV, putative
Plasmodium knowlesi PKNH_0830700   aspartyl protease, putative
Plasmodium vivax PVX_119690   aspartyl proteinase, putative
Plasmodium vivax PVX_086040   plasmepsin IV, putative
Plasmodium yoelii PY01714   hypothetical protein
Plasmodium yoelii PY06899   plasmepsin
Plasmodium yoelii PY01716   hypothetical protein
Saccharomyces cerevisiae YPL154C   Pep4p
Schistosoma japonicum Sjp_0302720   Cathepsin D precursor, putative
Schistosoma japonicum Sjp_0006800   ko:K01379 cathepsin D [EC3.4.23.5], putative
Schistosoma mansoni Smp_136730   subfamily A1A unassigned peptidase (A01 family)
Schistosoma mansoni Smp_013040.1   cathepsin D (A01 family)
Schistosoma mansoni Smp_013040.2   cathepsin D (A01 family)
Schmidtea mediterranea mk4.024765.00  
Schmidtea mediterranea mk4.016962.00  
Schmidtea mediterranea mk4.012002.00  
Toxoplasma gondii TGME49_262940   aspartyl proteinase (eimepsin), putative
Toxoplasma gondii TGME49_201840   aspartyl protease ASP1
Theileria parva TP01_0692   pepsinogen, putative
Theileria parva TP03_0056   cathepsin E, putative
Trichomonas vaginalis TVAG_336300   Clan AA, family A1, cathepsin D-like aspartic peptidase

Essentiality

Sjp_0302720 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1034400 Plasmodium berghei Slow plasmo
TGME49_262940 Toxoplasma gondii Essentiality uncertain sidik
TGME49_201840 Toxoplasma gondii Essentiality uncertain sidik
TGME49_262940 Toxoplasma gondii Probably non-essential sidik
TGME49_201840 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Plasmodium falciparum plasmepsin II Compounds References
Homo sapiens renin Compounds References
Plasmodium falciparum plasmepsin IV Compounds References
Oryctolagus cuniculus Renin Compounds References
Bos taurus Cathepsin D Compounds References
Callithrix jacchus Renin Compounds References
Macaca mulatta Renin Compounds References
Homo sapiens cathepsin E Compounds References
Schistosoma mansoni cathepsin D (A01 family) Compounds References
Mus musculus renin 1 structural Compounds References
Plasmodium vivax plasmepsin IV, putative Compounds References
Rhizopus microsporus var. chinensis Rhizopuspepsin Compounds References
Plasmodium falciparum plasmepsin I Compounds References
Homo sapiens cathepsin D Compounds References
Saccharomyces cerevisiae Pep4p Compounds References
Macaca fascicularis Renin Compounds References
Schistosoma mansoni cathepsin D (A01 family) Compounds References
Rattus norvegicus Renin Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Penicillium janthinellum Penicillopepsin 323 aa 26.6% 327 aa Compounds References
Sus scrofa Pepsin A 385 aa 37.8% 328 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0302720 (Schistosoma japonicum), Cathepsin D precursor, putative
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