Detailed view for Sjp_0104250

Basic information

TDR Targets ID: 974144
Schistosoma japonicum, TAR DNA-binding protein 43, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.6204 | Length (AA): 311 | MW (Da): 35390 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00076   RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

Gene Ontology

Mouse over links to read term descriptions.
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
105 273 4bs2 (A) 101 269 48.00 0.00047 1 1.16666 -0.56
110 180 5tbx (A) 9 81 32.00 0 1 0.757932 -1.5
112 156 2cq0 (A) 243 287 38.00 0.034 0.54 0.615961 -0.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132461)

Species Accession Gene Product
Brugia malayi Bm1_42820   TAR-binding protein
Brugia malayi Bm1_17250   RNA binding protein
Brugia malayi Bm1_17505   RNA recognition motif domain containing protein
Caenorhabditis elegans CELE_F44G4.4   Protein TDP-1, isoform B
Drosophila melanogaster Dmel_CG10327   TAR DNA-binding protein-43 homolog
Echinococcus granulosus EgrG_000472500   tar DNA binding protein
Echinococcus multilocularis EmuJ_000472500   tar DNA binding protein
Homo sapiens 23435   TAR DNA binding protein
Loa Loa (eye worm) LOAG_01833   TAR-binding protein
Loa Loa (eye worm) LOAG_01262   RNA binding protein
Loa Loa (eye worm) LOAG_05785   RNA recognition domain-containing protein domain-containing protein
Mus musculus ENSMUSG00000041459   TAR DNA binding protein
Schistosoma japonicum Sjp_0104250   TAR DNA-binding protein 43, putative
Schistosoma japonicum Sjp_0201080   TAR DNA-binding protein 43, putative
Schistosoma mansoni Smp_051300   tar DNA-binding protein
Schistosoma mansoni Smp_051230.2   tar DNA-binding protein
Schistosoma mansoni Smp_051230.1   tar DNA-binding protein
Schistosoma mansoni Smp_051230.4   tar DNA-binding protein
Schistosoma mansoni Smp_051230.3   tar DNA-binding protein
Schmidtea mediterranea mk4.000916.09   TAR DNA-binding protein 43
Schmidtea mediterranea mk4.000175.05   TAR DNA-binding protein 43
Schmidtea mediterranea mk4.000175.13   TAR DNA-binding protein 43
Schmidtea mediterranea mk4.000238.08   TAR DNA-binding protein 43

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens TAR DNA binding protein Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0104250 (Schistosoma japonicum), TAR DNA-binding protein 43, putative
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