Detailed view for Sjp_0017590

Basic information

TDR Targets ID: 974173
Schistosoma japonicum, IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai
Source Database / ID:  Wormbase Parasite  

pI: 9.5457 | Length (AA): 482 | MW (Da): 55853 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07714   Protein tyrosine kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005509   calcium ion binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
221 272 4rt7 (A) 600 651 53.00 0.77 0.17 0.451308 0.9
366 473 5d43 (A) 29 133 26.00 0.16 0.98 0.638732 -0.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128769)

Species Accession Gene Product
Brugia malayi Bm1_40455   Immunoglobulin I-set domain containing protein
Caenorhabditis elegans CELE_F58A3.2   Protein EGL-15, isoform A
Drosophila melanogaster Dmel_CG32134   breathless
Drosophila melanogaster Dmel_CG7223   heartless
Echinococcus granulosus EgrG_000196200   basic fibroblast growth factor receptor 1 A
Echinococcus granulosus EgrG_000833200   fibroblast growth factor receptor 4
Echinococcus multilocularis EmuJ_000196200   basic fibroblast growth factor receptor 1 A
Echinococcus multilocularis EmuJ_000833200   fibroblast growth factor receptor 4
Homo sapiens ENSG00000066468   fibroblast growth factor receptor 2
Homo sapiens ENSG00000160867   fibroblast growth factor receptor 4
Homo sapiens ENSG00000077782   fibroblast growth factor receptor 1
Homo sapiens ENSG00000068078   fibroblast growth factor receptor 3
Loa Loa (eye worm) LOAG_04978   TK protein kinase
Mus musculus ENSMUSG00000030849   fibroblast growth factor receptor 2
Mus musculus ENSMUSG00000005320   fibroblast growth factor receptor 4
Mus musculus ENSMUSG00000054252   fibroblast growth factor receptor 3
Mus musculus ENSMUSG00000031565   fibroblast growth factor receptor 1
Schistosoma japonicum Sjp_0017590   IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai
Schistosoma japonicum Sjp_0112660   Fibroblast growth factor receptor precursor, putative
Schistosoma mansoni Smp_157300   tyrosine kinase
Schmidtea mediterranea mk4.001255.02  

Essentiality

Sjp_0017590 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F58A3.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F58A3.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens fibroblast growth factor receptor 1 Compounds References
Homo sapiens fibroblast growth factor receptor 3 Compounds References
Mus musculus fibroblast growth factor receptor 3 Compounds References
Mus musculus fibroblast growth factor receptor 1 Compounds References
Mus musculus fibroblast growth factor receptor 4 Compounds References
Mus musculus fibroblast growth factor receptor 2 Compounds References
Homo sapiens fibroblast growth factor receptor 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0017590 (Schistosoma japonicum), IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai
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