Detailed view for Sjp_0202670

Basic information

TDR Targets ID: 974474
Schistosoma japonicum, Tyrosine-protein kinase CSK, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.1133 | Length (AA): 729 | MW (Da): 81999 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00017   SH2 domain
PF00018   SH3 domain
PF07714   Protein tyrosine kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133402)

Species Accession Gene Product
Brugia malayi Bm1_56715   SH2 domain containing protein
Caenorhabditis elegans CELE_Y48G1C.2   Protein CSK-1
Drosophila melanogaster Dmel_CG42317   C-terminal Src kinase
Echinococcus granulosus EgrG_000588500   tyrosine protein kinase csk
Echinococcus granulosus EgrG_000588200   tyrosine protein kinase csk
Echinococcus granulosus EgrG_000588400   tyrosine protein kinase csk
Echinococcus granulosus EgrG_000342000   c src tyrosine kinase
Echinococcus multilocularis EmuJ_000588200   tyrosine protein kinase csk
Echinococcus multilocularis EmuJ_000588100   tyrosine protein kinase csk
Echinococcus multilocularis EmuJ_000588500   tyrosine protein kinase csk
Echinococcus multilocularis EmuJ_000588400   tyrosine protein kinase csk
Echinococcus multilocularis EmuJ_000342000   c src tyrosine kinase
Homo sapiens ENSG00000103653   c-src tyrosine kinase
Loa Loa (eye worm) LOAG_09906   SH2 domain-containing protein
Loa Loa (eye worm) LOAG_13069   TK/CSK protein kinase
Mus musculus ENSMUSG00000032312   c-src tyrosine kinase
Onchocerca volvulus OVOC1531  
Schistosoma japonicum Sjp_0202670   Tyrosine-protein kinase CSK, putative
Schistosoma mansoni Smp_125360   tyrosine kinase
Schmidtea mediterranea mk4.004443.00   CSK-1
Schmidtea mediterranea mk4.002065.04   CSK-1
Schmidtea mediterranea mk4.002330.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens c-src tyrosine kinase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Jak1 protein 210 aa 24.4% 270 aa Compounds References
Sus scrofa Casein kinase I isoform alpha 125 aa 27.8% 126 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0202670 (Schistosoma japonicum), Tyrosine-protein kinase CSK, putative
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