Detailed view for Sjp_0300610

Basic information

TDR Targets ID: 974493
Schistosoma japonicum, ko:K08596 sentrin-specific protease 7, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.115 | Length (AA): 707 | MW (Da): 79724 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02902   Ulp1 protease family, C-terminal catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008234   cysteine-type peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131076)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0293508   hypothetical protein
Dictyostelium discoideum DDB_G0289557   hypothetical protein
Drosophila melanogaster Dmel_CG10107   veloren
Echinococcus granulosus EgrG_000060300   sentrin specific protease 7
Echinococcus granulosus EgrG_000121300   expressed conserved protein
Entamoeba histolytica EHI_138530   Ulp1 protease family, C-terminal catalytic domain containing protein
Echinococcus multilocularis EmuJ_000060300   sentrin specific protease 7
Echinococcus multilocularis EmuJ_000121300   expressed conserved protein
Homo sapiens ENSG00000138468   SUMO1/sentrin specific peptidase 7
Mus musculus ENSMUSG00000052917   SUMO1/sentrin specific peptidase 7
Schistosoma japonicum Sjp_0300610   ko:K08596 sentrin-specific protease 7, putative
Schistosoma mansoni Smp_159120   family C48 unassigned peptidase (C48 family)
Schmidtea mediterranea mk4.001544.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens SUMO1/sentrin specific peptidase 7 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0300610 (Schistosoma japonicum), ko:K08596 sentrin-specific protease 7, putative
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