Detailed view for Sjp_0061170

Basic information

TDR Targets ID: 974851
Schistosoma japonicum, Tankyrase-1, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.4468 | Length (AA): 487 | MW (Da): 53086 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00536   SAM domain (Sterile alpha motif)
PF00644   Poly(ADP-ribose) polymerase catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0003950   NAD+ ADP-ribosyltransferase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
135 194 5jrt (A) 877 936 48.00 0 1 0.845457 -1.73
147 438 4zzz (B) 671 1005 22.00 0 1 0.609823 0.5
158 193 1b0x (A) 939 974 31.00 0.89 0.76 0.492874 -0.44
252 444 4hyf (A) 948 1161 60.00 0 1 0.958119 -0.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131205)

Species Accession Gene Product
Brugia malayi Bm1_32600   Tnks protein
Dictyostelium discoideum DDB_G0274389   WWE domain-containing protein
Drosophila melanogaster Dmel_CG4719   tankyrase
Echinococcus granulosus EgrG_001096000   tankyrase
Echinococcus multilocularis EmuJ_001096000   tankyrase
Homo sapiens ENSG00000107854   tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Homo sapiens ENSG00000173273   tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Loa Loa (eye worm) LOAG_00097   hypothetical protein
Loa Loa (eye worm) LOAG_05104   tnks protein
Mus musculus ENSMUSG00000024811   tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Mus musculus ENSMUSG00000031529   tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Oryza sativa 4345102   Os08g0258200
Onchocerca volvulus OVOC3050   Tankyrase homolog
Schistosoma japonicum Sjp_0061170   Tankyrase-1, putative
Schistosoma japonicum Sjp_0022590   ko:K00774 NAD ADP-ribosyltransferase [EC2.4.2.30], putative
Schistosoma mansoni Smp_128950   tankyrase
Schmidtea mediterranea mk4.000820.05   Tankyrase
Schmidtea mediterranea mk4.000820.07   Tankyrase
Schmidtea mediterranea mk4.000820.04   Tankyrase
Schmidtea mediterranea mk4.000820.06   Tankyrase
Theileria parva TP02_0736   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 Compounds References
Mus musculus tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase Compounds References
Homo sapiens tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase Compounds References
Mus musculus tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0061170 (Schistosoma japonicum), Tankyrase-1, putative
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