Detailed view for Sjp_0058790

Basic information

TDR Targets ID: 975353
Schistosoma japonicum, ko:K05194 glycine receptor, alpha 2, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.9819 | Length (AA): 498 | MW (Da): 57376 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 4

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02931   Neurotransmitter-gated ion-channel ligand binding domain
PF02932   Neurotransmitter-gated ion-channel transmembrane region

Gene Ontology

Mouse over links to read term descriptions.
GO:0034220   transmembrane ion transport  
GO:0016021   integral to membrane  
GO:0005230   extracellular ligand-gated ion channel activity  
GO:0005216   ion channel activity  
GO:0004888   transmembrane receptor activity  
GO:0006811   ion transport  

Metabolic Pathways

Neuroactive ligand-receptor interaction (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
34 271 2qc1 (B) 8 210 23.00 0 0.93 0.547573 0.37
34 368 5o8f (A) 16 322 32.00 0 1 0.885744 0.61
71 365 5cfb (D) 36 321 44.00 0 1 0.983561 0.73
367 467 4n5c (E) 373 489 14.00 0 0.03 0.327919 -0.29
456 494 4x5t (A) 305 411 28.00 0.074 0.05 0.0857708 2.65

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128286)

Species Accession Gene Product
Brugia malayi Bm1_00335   glutamate-gated chloride channel alpha3A subunit, putative
Brugia malayi Bm1_08185   Cation transporter family protein
Brugia malayi Bm1_15450   glutamate-gated chloride channel alpha3A subunit, putative
Caenorhabditis elegans CELE_R11G10.1a   Protein AVR-15, isoform B
Caenorhabditis elegans CELE_ZC317.3   Protein GLC-3
Caenorhabditis elegans CELE_F25F8.2   Protein GLC-2
Caenorhabditis elegans CELE_B0207.12   Protein AVR-14, isoform C
Caenorhabditis elegans CELE_R11G10.1   Protein AVR-15, isoform A
Caenorhabditis elegans CELE_F11H8.2   Protein LGC-38
Caenorhabditis elegans CELE_F11A5.10   Protein GLC-1
Drosophila melanogaster Dmel_CG7535   CG7535 gene product from transcript CG7535-RK
Drosophila melanogaster Dmel_CG10537   Resistant to dieldrin
Echinococcus granulosus EgrG_001096400   Cys loop ligand gated ion channel subunit
Echinococcus granulosus EgrG_001119800   glycine receptor subunit alpha 1
Echinococcus granulosus EgrG_000670700   glycine receptor subunit beta
Echinococcus granulosus EgrG_001156400   Cys loop ligand gated ion channel subunit
Echinococcus granulosus EgrG_000668200   glycine receptor subunit alpha 1
Echinococcus granulosus EgrG_000506600   glycine receptor subunit alpha 1
Echinococcus granulosus EgrG_000506500   glycine receptor subunit beta
Echinococcus multilocularis EmuJ_000506600   glycine receptor subunit alpha 1
Echinococcus multilocularis EmuJ_000670700   glycine receptor subunit beta
Echinococcus multilocularis EmuJ_000506500   glycine receptor subunit beta
Echinococcus multilocularis EmuJ_001096400   Cys loop ligand gated ion channel subunit
Echinococcus multilocularis EmuJ_001156400   Cys loop ligand gated ion channel subunit
Echinococcus multilocularis EmuJ_000668200   glycine receptor subunit alpha 1
Echinococcus multilocularis EmuJ_001119800   glycine receptor subunit alpha 1
Homo sapiens ENSG00000145888   glycine receptor, alpha 1
Homo sapiens ENSG00000145451   glycine receptor, alpha 3
Homo sapiens ENSG00000188828   glycine receptor, alpha 4
Homo sapiens ENSG00000101958   glycine receptor, alpha 2
Loa Loa (eye worm) LOAG_07842   hypothetical protein
Loa Loa (eye worm) LOAG_11352   glutamate-gated chloride channel alpha3A subunit
Loa Loa (eye worm) LOAG_02645   hypothetical protein
Loa Loa (eye worm) LOAG_12210   GABA receptor subunit
Loa Loa (eye worm) LOAG_06656   glutamate-gated chloride channel alpha3A subunit
Mus musculus 14657   glycine receptor, alpha 4 subunit
Mus musculus ENSMUSG00000018589   glycine receptor, alpha 2 subunit
Mus musculus 14654   glycine receptor, alpha 1 subunit
Mus musculus 110304   glycine receptor, alpha 3 subunit
Schistosoma japonicum Sjp_0214580   ko:K05195 glycine receptor, alpha 3, putative
Schistosoma japonicum Sjp_0034810   Glycine receptor subunit alpha-3 precursor, putative
Schistosoma japonicum Sjp_0058790   ko:K05194 glycine receptor, alpha 2, putative
Schistosoma mansoni Smp_104890   Cys-loop ligand gated ion channel subunit
Schistosoma mansoni Smp_015630   Cys-loop ligand gated ion channel subunit
Schistosoma mansoni Smp_096480   Cys-loop ligand gated ion channel subunit
Schmidtea mediterranea mk4.002158.00   Putative cys-loop ligand gated ion channel subunit
Schmidtea mediterranea mk4.001914.01  
Schmidtea mediterranea mk4.008948.03  
Schmidtea mediterranea mk4.000414.08   Putative cys-loop ligand gated ion channel subunit
Schmidtea mediterranea mk4.001114.04  
Schmidtea mediterranea mk4.004036.03  
Schmidtea mediterranea mk4.002254.00  
Schmidtea mediterranea mk4.000708.03  
Schmidtea mediterranea mk4.002893.03  
Schmidtea mediterranea mk4.000681.10  

Essentiality

Sjp_0058790 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F25F8.2 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Glycine receptor subunit alpha-1 Compounds References
Musca domestica GABA receptor subunit Compounds References
Mus musculus glycine receptor, alpha 4 subunit Compounds References
Homo sapiens glycine receptor, alpha 3 Compounds References
Homo sapiens glycine receptor, alpha 1 Compounds References
Homo sapiens glycine receptor, alpha 2 Compounds References
Rattus norvegicus Glycine receptor subunit alpha-2 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus GABA A receptor alpha-5/beta-3/gamma-2 473 aa 28.0% 443 aa Compounds References
Rattus norvegicus GABA A receptor alpha-2/beta-2/gamma-2 451 aa 30.4% 431 aa Compounds References
Rattus norvegicus GABA receptor gamma-1 subunit 465 aa 26.4% 432 aa Compounds References
Rattus norvegicus Glycine receptor 496 aa 32.5% 456 aa Compounds References
Rattus norvegicus GABA receptor alpha-2 subunit 451 aa 30.4% 431 aa Compounds References
Rattus norvegicus GABA receptor alpha-5 subunit 464 aa 29.7% 435 aa Compounds References
Rattus norvegicus GABA-A receptor; alpha-1/beta-2/gamma-2 455 aa 29.9% 432 aa Compounds References
Rattus norvegicus GABA A receptor alpha-3/beta-2/gamma-2 493 aa 29.7% 438 aa Compounds References
Rattus norvegicus GABA receptor alpha-6 subunit 453 aa 28.9% 432 aa Compounds References
Rattus norvegicus GABA receptor alpha-1 subunit 455 aa 29.9% 432 aa Compounds References
Rattus norvegicus GABA receptor alpha-3 subunit 493 aa 29.7% 438 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Sjp_0058790 (Schistosoma japonicum), ko:K05194 glycine receptor, alpha 2, putative
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