Detailed view for Sjp_0303220

Basic information

TDR Targets ID: 975825
Schistosoma japonicum, Snurportin-1, putative
Source Database / ID:  Wormbase Parasite  

pI: 5.4396 | Length (AA): 350 | MW (Da): 41192 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF11538   Snurportin1

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

RNA transport (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131808)

Species Accession Gene Product
Arabidopsis thaliana AT4G24880   hypothetical protein
Brugia malayi Bm1_00700   RNA, U transporter 1
Caenorhabditis elegans CELE_F23F1.5   Protein F23F1.5
Dictyostelium discoideum DDB_G0282431   hypothetical protein
Drosophila melanogaster Dmel_CG42303   Snurportin
Echinococcus granulosus EgrG_001054900   snurportin 1
Echinococcus multilocularis EmuJ_001054900   snurportin 1
Homo sapiens ENSG00000169371   snurportin 1
Loa Loa (eye worm) LOAG_11105   nucleolar RNA-associated protein alpha
Mus musculus ENSMUSG00000055334   snurportin 1
Oryza sativa 4326461   Os01g0101300
Schistosoma japonicum Sjp_0303220   Snurportin-1, putative
Schistosoma mansoni Smp_134880   hypothetical protein
Schmidtea mediterranea mk4.007059.00   Snurportin-1
Schmidtea mediterranea mk4.005697.00   Snurportin-1
Schmidtea mediterranea mk4.000463.08   Snurportin-1
Schmidtea mediterranea mk4.006721.00   Snurportin-1
Schmidtea mediterranea mk4.001068.00  
Schmidtea mediterranea mk4.004235.00  

Essentiality

Sjp_0303220 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F23F1.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_F23F1.5 Caenorhabditis elegans larval arrest wormbase
CELE_F23F1.5 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens snurportin 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0303220 (Schistosoma japonicum), Snurportin-1, putative
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