Detailed view for Sjp_0098990

Basic information

TDR Targets ID: 976131
Schistosoma japonicum, Voltage-dependent calcium channel type D subunit alpha-1, putative
Source Database / ID:  Wormbase Parasite  

pI: 10.2269 | Length (AA): 112 | MW (Da): 12752 | Paralog Number: 17

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 2

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00520   Ion transport protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005216   ion channel activity  
GO:0055085   transmembrane transport  
GO:0006811   ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 110 5dqq (A) 434 545 24.00 0.0000000029 0.01 1.06915 0.92
52 110 5co8 (C) 46 113 37.00 0.46 0.86 0.794832 1.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126791)

Species Accession Gene Product
Brugia malayi Bm1_39550   Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog
Caenorhabditis elegans CELE_C48A7.1   Protein EGL-19, isoform B
Caenorhabditis elegans CELE_T02C5.5   Protein UNC-2, isoform E
Drosophila melanogaster Dmel_CG4894   Ca[2+]-channel protein alpha[[1]] subunit D
Drosophila melanogaster Dmel_CG43368   cacophony
Echinococcus granulosus EgrG_000146200   voltage dependent calcium channel
Echinococcus granulosus EgrG_000960800   voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu
Echinococcus granulosus EgrG_000890600   voltage dependent L type calcium channel subunit|voltage dependent calcium channel
Echinococcus granulosus EgrG_000143700   voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1
Echinococcus granulosus EgrG_000146300   voltage dependent calcium channel
Echinococcus multilocularis EmuJ_000961000   voltage dependent L type calcium channel subunit
Echinococcus multilocularis EmuJ_000146300   voltage dependent calcium channel
Echinococcus multilocularis EmuJ_000138000   voltage dependent calcium channel
Echinococcus multilocularis EmuJ_000890600   voltage dependent L type calcium channel subunit
Echinococcus multilocularis EmuJ_000140800   voltage dependent calcium channel type d subunit
Echinococcus multilocularis EmuJ_000143800   voltage dependent calcium channel type d subunit
Homo sapiens ENSG00000141837   calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Homo sapiens ENSG00000148408   calcium channel, voltage-dependent, N type, alpha 1B subunit
Homo sapiens ENSG00000102001   calcium channel, voltage-dependent, L type, alpha 1F subunit
Homo sapiens ENSG00000198216   calcium channel, voltage-dependent, R type, alpha 1E subunit
Homo sapiens ENSG00000151067   calcium channel, voltage-dependent, L type, alpha 1C subunit
Homo sapiens ENSG00000157388   calcium channel, voltage-dependent, L type, alpha 1D subunit
Homo sapiens ENSG00000081248   calcium channel, voltage-dependent, L type, alpha 1S subunit
Loa Loa (eye worm) LOAG_00278   hypothetical protein
Loa Loa (eye worm) LOAG_03551   hypothetical protein
Loa Loa (eye worm) LOAG_08971   hypothetical protein
Loa Loa (eye worm) LOAG_12454   calcium channel
Loa Loa (eye worm) LOAG_03549   hypothetical protein
Loa Loa (eye worm) LOAG_03550   voltage-dependent calcium channel
Mus musculus ENSMUSG00000004113   calcium channel, voltage-dependent, N type, alpha 1B subunit
Mus musculus ENSMUSG00000034656   calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Mus musculus ENSMUSG00000031142   calcium channel, voltage-dependent, alpha 1F subunit
Mus musculus ENSMUSG00000015968   calcium channel, voltage-dependent, L type, alpha 1D subunit
Mus musculus ENSMUSG00000004110   calcium channel, voltage-dependent, R type, alpha 1E subunit
Mus musculus ENSMUSG00000026407   calcium channel, voltage-dependent, L type, alpha 1S subunit
Mus musculus ENSMUSG00000051331   calcium channel, voltage-dependent, L type, alpha 1C subunit
Neospora caninum NCLIV_020420   hypothetical protein
Schistosoma japonicum Sjp_0098990   Voltage-dependent calcium channel type D subunit alpha-1, putative
Schistosoma japonicum Sjp_0120260   Muscle calcium channel subunit alpha-1, putative
Schistosoma japonicum Sjp_0202920   Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative
Schistosoma japonicum Sjp_0097250   Voltage-dependent calcium channel type A subunit alpha-1, putative
Schistosoma japonicum Sjp_0010120   ko:K04850 calcium channel, voltage-dependent, L type, alpha 1C subunit, putative
Schistosoma japonicum Sjp_0073860   Voltage-dependent N-type calcium channel subunit alpha-1B, putative
Schistosoma japonicum Sjp_0096680   ko:K04849 calcium channel, voltage-dependent, N type, alpha 1B subunit, putative
Schistosoma japonicum Sjp_0119180   Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative
Schistosoma japonicum Sjp_0131020   Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative
Schistosoma japonicum Sjp_0134440   expressed protein
Schistosoma japonicum Sjp_0014170   Probable voltage-dependent R-type calcium channel subunit alpha-1E, putative
Schistosoma japonicum Sjp_0010110   ko:K04853 calcium channel, voltage-dependent, L type, alpha 1F subunit, putative
Schistosoma japonicum Sjp_0099010   Voltage-dependent calcium channel type D subunit alpha-1, putative
Schistosoma japonicum Sjp_0016770   ko:K04344 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, putative
Schistosoma japonicum Sjp_0092750   Voltage-dependent calcium channel type A subunit alpha-1, putative
Schistosoma japonicum Sjp_0210160   expressed protein
Schistosoma japonicum Sjp_0016780   Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative
Schistosoma japonicum Sjp_0106840   Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative
Schistosoma mansoni Smp_020270   high voltage-activated calcium channel Cav1
Schistosoma mansoni Smp_159990   voltage-gated cation channel
Schistosoma mansoni Smp_020170   high voltage-activated calcium channel Cav2A
Schmidtea mediterranea mk4.001377.11  
Schmidtea mediterranea mk4.008848.04  
Schmidtea mediterranea mk4.001377.16  
Schmidtea mediterranea mk4.001377.10  
Schmidtea mediterranea mk4.008848.05  
Schmidtea mediterranea mk4.012932.01  
Schmidtea mediterranea mk4.001377.09   Voltage-dependent calcium channel
Schmidtea mediterranea mk4.008848.02  
Schmidtea mediterranea mk4.018105.05  
Schmidtea mediterranea mk4.004365.03  
Schmidtea mediterranea mk4.019777.01   Voltage-dependent L-type calcium channel subunit alpha-1F
Schmidtea mediterranea mk4.023155.00  
Schmidtea mediterranea mk4.029272.00  
Schmidtea mediterranea mk4.008848.03   Voltage-dependent L-type calcium channel subunit alpha-1F
Schmidtea mediterranea mk4.015205.00  
Schmidtea mediterranea mk4.025288.02  
Schmidtea mediterranea mk4.011861.01  
Schmidtea mediterranea mk4.008848.00  
Schmidtea mediterranea mk4.001377.13  
Schmidtea mediterranea mk4.027021.01  
Schmidtea mediterranea mk4.011008.02  
Schmidtea mediterranea mk4.001377.14  
Schmidtea mediterranea mk4.009459.00   Voltage-dependent calcium channel
Schmidtea mediterranea mk4.019777.00   Voltage-dependent calcium channel type A subunit alpha-1
Schmidtea mediterranea mk4.005283.00   Voltage-dependent calcium channel
Schmidtea mediterranea mk4.028156.00  
Schmidtea mediterranea mk4.011008.01  
Schmidtea mediterranea mk4.001377.12  
Schmidtea mediterranea mk4.011008.00   Voltage-dependent T-type calcium channel subunit alpha-1H
Schmidtea mediterranea mk4.018105.02  
Schmidtea mediterranea mk4.004486.00   Voltage-dependent calcium channel
Schmidtea mediterranea mk4.001377.15  
Schmidtea mediterranea mk4.011251.01   Voltage-dependent calcium channel type A subunit alpha-1
Schmidtea mediterranea mk4.027021.00  
Schmidtea mediterranea mk4.011861.00  
Schmidtea mediterranea mk4.011303.00   Skeletal muscle L-type calcium channel alpha1S subunit
Schmidtea mediterranea mk4.023155.02  
Schmidtea mediterranea mk4.012932.00  
Schmidtea mediterranea mk4.018221.00   Voltage-dependent L-type calcium channel subunit alpha-1F
Schmidtea mediterranea mk4.005283.02   Voltage-dependent calcium channel
Schmidtea mediterranea mk4.008848.01  
Schmidtea mediterranea mk4.005283.04   Voltage-dependent calcium channel
Trypanosoma brucei gambiense Tbg972.10.3590   calcium channel protein, putative
Trypanosoma brucei Tb927.10.2880   Voltage-dependent calcium channel subunit, putative
Trypanosoma congolense TcIL3000_10_2490   Voltage-dependent calcium channel subunit, putative
Trypanosoma cruzi TcCLB.504105.130   Voltage-dependent calcium channel subunit, putative
Toxoplasma gondii TGME49_244105   hypothetical protein
Toxoplasma gondii TGME49_205265   transporter, cation channel family protein

Essentiality

Sjp_0098990 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.2880 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.2880 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.2880 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.2880 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_205265 Toxoplasma gondii Probably non-essential sidik
TGME49_244105 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit Compounds References
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit Compounds References
Homo sapiens calcium channel, voltage-dependent, L type, alpha 1C subunit Compounds References
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1S subunit Compounds References
Mus musculus calcium channel, voltage-dependent, L type, alpha 1C subunit Compounds References
Oryctolagus cuniculus Voltage-gated L-type calcium channel alpha-1S subunit Compounds References
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C Compounds References
Homo sapiens calcium channel, voltage-dependent, L type, alpha 1D subunit Compounds References
Homo sapiens calcium channel, voltage-dependent, N type, alpha 1B subunit Compounds References
Blattella germanica Voltage-dependent calcium channel alpha-1 subunit Compounds References
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1D subunit Compounds References
Homo sapiens calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Compounds References
Homo sapiens calcium channel, voltage-dependent, L type, alpha 1F subunit Compounds References
Oryctolagus cuniculus Voltage-gated L-type calcium channel alpha-1C subunit Compounds References
Homo sapiens calcium channel, voltage-dependent, L type, alpha 1S subunit Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Sjp_0098990 (Schistosoma japonicum), Voltage-dependent calcium channel type D subunit alpha-1, putative
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