pI: 4.3243 |
Length (AA): 92 |
MW (Da): 10014 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 77 | 3lfv (B) | 179 | 246 | 47.00 | 0.00027 | 0.29 | 0.916298 | 1.45 |
5 | 90 | 2k31 (A) | 169 | 249 | 35.00 | 0 | 0.82 | 1.19795 | 0.95 |
5 | 90 | 1mc0 (A) | 417 | 488 | 43.00 | 0.0000053 | 0.83 | 1.12815 | 1.3 |
5 | 90 | 3dba (A) | 90 | 172 | 35.00 | 0.000043 | 0.75 | 1.24415 | 0.86 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127318)
Species | Accession | Gene Product |
---|---|---|
Candida albicans | CaO19.10489 | similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase |
Candida albicans | CaO19.2972 | similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase |
Dictyostelium discoideum | DDB_G0268634 | cGMP-specific phosphodiesterase |
Drosophila melanogaster | Dmel_CG34341 | Phosphodiesterase 11 |
Drosophila melanogaster | Dmel_CG8279 | Phosphodiesterase 6 |
Echinococcus granulosus | EgrG_000678400 | dual 3'5' cyclic AMP and GMP phosphodiesterase |
Echinococcus multilocularis | EmuJ_000678400 | dual 3',5' cyclic AMP and GMP phosphodiesterase |
Homo sapiens | ENSG00000128655 | phosphodiesterase 11A |
Homo sapiens | ENSG00000138735 | phosphodiesterase 5A, cGMP-specific |
Leishmania braziliensis | LbrM.15.1250 | cAMP specific phosphodiesterase, putative |
Leishmania braziliensis | LbrM.15.1480 | cAMP specific phosphodiesterase, putative |
Leishmania donovani | LdBPK_151540.1 | cAMP specific phosphodiesterase, putative |
Leishmania infantum | LinJ.15.1540 | cAMP specific phosphodiesterase, putative |
Leishmania infantum | LinJ.15.1550 | cAMP specific phosphodiesterase, putative |
Leishmania mexicana | LmxM.15.1480 | cAMP specific phosphodiesterase, putative |
Leishmania mexicana | LmxM.15.1481 | cAMP specific phosphodiesterase, putative |
Mus musculus | ENSMUSG00000053965 | phosphodiesterase 5A, cGMP-specific |
Mus musculus | 241489 | phosphodiesterase 11A |
Saccharomyces cerevisiae | YOR360C | 3',5'-cyclic-nucleotide phosphodiesterase PDE2 |
Schistosoma japonicum | Sjp_0021620 | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative |
Schistosoma japonicum | Sjp_0215050 | expressed protein |
Schistosoma japonicum | Sjp_0021610 | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative |
Schistosoma japonicum | Sjp_0134390 | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative |
Schistosoma mansoni | Smp_179590 | camp/cgmp cyclic nucleotide phosphodiesterase |
Schmidtea mediterranea | mk4.006743.01 | |
Schmidtea mediterranea | mk4.006234.04 | |
Schmidtea mediterranea | mk4.012753.02 | |
Schmidtea mediterranea | mk4.006743.02 | |
Schmidtea mediterranea | mk4.023897.00 | |
Schmidtea mediterranea | mk4.010357.01 | |
Schmidtea mediterranea | mk4.006234.06 | Putative camp/cgmp cyclic nucleotide phosphodiesterase |
Schmidtea mediterranea | mk4.008467.01 | |
Trypanosoma brucei gambiense | Tbg972.9.2710 | cAMP-specific phosphodiesterase, putative |
Trypanosoma brucei gambiense | Tbg972.9.2700 | cAMP-specific phosphodiesterase, putative |
Trypanosoma brucei | Tb927.9.5100 | cAMP-specific phosphodiesterase |
Trypanosoma brucei | Tb927.9.5040 | cAMP-specific phosphodiesterase |
Trypanosoma congolense | TcIL3000_9_1670 | cAMP-specific phosphodiesterase, putative |
Trypanosoma congolense | TcIL3000_0_03910 | cAMP-specific phosphodiesterase |
Trypanosoma cruzi | TcCLB.509943.20 | cAMP specific phosphodiesterase, putative |
Trypanosoma cruzi | TcCLB.508277.110 | cAMP specific phosphodiesterase, putative |
Trypanosoma cruzi | TcCLB.508277.100 | cAMP specific phosphodiesterase, putative |
Trypanosoma cruzi | TcCLB.509943.11 | cAMP specific phosphodiesterase, putative |
Toxoplasma gondii | TGME49_200295 | hypothetical protein |
Trichomonas vaginalis | TVAG_043880 | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_333170 | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_416790 | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_230840 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_446730 | cyclic nucleotide phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_371830 | cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_495630 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_265300 | cAMP/cGMP cyclic nucleotide phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_138390 | cyclic nucleotide phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_437180 | cAMP-specific phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_335090 | cGMP-specific 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_172570 | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_136710 | cAMP-specific 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_059390 | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_260330 | cAMP-specific phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_261720 | cGMP-inhibited 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_119150 | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_055620 | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_499580 | cAMP-specific phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_405840 | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_083500 | cGMP-specific 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_426800 | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_046890 | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_407110 | cGMP-dependent 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_186700 | cyclic nucleotide phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_346760 | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_438020 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_134900 | cAMP-specific 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_271730 | cGMP-specific 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_195020 | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_027930 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_163530 | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_225750 | cGMP-dependent 3,5-cyclic phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_052120 | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.3590 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.3590 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.3590 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.160.3590 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb09.160.3630 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.3630 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.3630 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb09.160.3630 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_200295 | Toxoplasma gondii | Probably non-essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Trypanosoma brucei gambiense | cAMP-specific phosphodiesterase, putative | Compounds | References |
Rattus norvegicus | Phosphodiesterase 5A | Compounds | References |
Leishmania major | Class I phosphodiesterase PDEB1 | Compounds | References |
Canis lupus famiaris | Phosphodiesterase 5A | Compounds | References |
Homo sapiens | phosphodiesterase 11A | Compounds | References |
Trypanosoma brucei | cAMP-specific phosphodiesterase | Compounds | References |
Homo sapiens | phosphodiesterase 5A, cGMP-specific | Compounds | References |
Bos taurus | Phosphodiesterase 5A | Compounds | References |