Detailed view for Sjp_0094810

Basic information

TDR Targets ID: 976542
Schistosoma japonicum, hypothetical protein
Source Database / ID:  Wormbase Parasite  

pI: 4.922 | Length (AA): 79 | MW (Da): 8915 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 77 5k5t (A) 468 546 38.00 0.00000089 0.57 1.24812 0.71

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127095)

Species Accession Gene Product
Brugia malayi Bm1_38180   Metabotropic glutamate receptor precursor.
Brugia malayi Bm1_13620   metabotropic glutamate receptor subtype 5a (mGluR5a), putative
Caenorhabditis elegans CELE_F45H11.4   Protein MGL-2
Caenorhabditis elegans CELE_ZC506.4   Protein MGL-1, isoform A
Drosophila melanogaster Dmel_CG11144   metabotropic Glutamate Receptor
Drosophila melanogaster Dmel_CG30361   mangetout
Echinococcus granulosus EgrG_000591300   metabotropic glutamate receptor 5
Echinococcus granulosus EgrG_000259000   metabotropic glutamate receptor 2
Echinococcus multilocularis EmuJ_000591300   metabotropic glutamate receptor 5
Echinococcus multilocularis EmuJ_000259000   metabotropic glutamate receptor 2
Homo sapiens ENSG00000113262   glutamate receptor, metabotropic 6
Homo sapiens ENSG00000196277   glutamate receptor, metabotropic 7
Homo sapiens ENSG00000168959   glutamate receptor, metabotropic 5
Homo sapiens ENSG00000152822   glutamate receptor, metabotropic 1
Homo sapiens ENSG00000198822   glutamate receptor, metabotropic 3
Homo sapiens ENSG00000164082   glutamate receptor, metabotropic 2
Homo sapiens ENSG00000179603   glutamate receptor, metabotropic 8
Homo sapiens ENSG00000124493   glutamate receptor, metabotropic 4
Loa Loa (eye worm) LOAG_07544   hypothetical protein
Loa Loa (eye worm) LOAG_08934   glutamate receptor
Mus musculus ENSMUSG00000023192   glutamate receptor, metabotropic 2
Mus musculus ENSMUSG00000049583   glutamate receptor, metabotropic 5
Mus musculus ENSMUSG00000056755   glutamate receptor, metabotropic 7
Mus musculus ENSMUSG00000000617   glutamate receptor, metabotropic 6
Mus musculus ENSMUSG00000024211   glutamate receptor, metabotropic 8
Mus musculus ENSMUSG00000019828   glutamate receptor, metabotropic 1
Mus musculus ENSMUSG00000063239   glutamate receptor, metabotropic 4
Mus musculus ENSMUSG00000003974   glutamate receptor, metabotropic 3
Schistosoma japonicum Sjp_0094830   Metabotropic glutamate receptor precursor, putative
Schistosoma japonicum Sjp_0094810   hypothetical protein
Schistosoma japonicum Sjp_0088520   ko:K04606 glutamate receptor, metabotropic 3, putative
Schistosoma mansoni Smp_052660   metabotropic glutamate receptor
Schistosoma mansoni Smp_150370   metabotropic glutamate receptor 2 3 (mglur group 2)
Schmidtea mediterranea mk4.021267.00  
Schmidtea mediterranea mk4.010162.00   Putative metabotropic glutamate receptor
Schmidtea mediterranea mk4.025402.00   Putative metabotropic glutamate receptor
Schmidtea mediterranea mk4.005356.00   Putative metabotropic glutamate receptor
Schmidtea mediterranea mk4.020523.00   Metabotropic glutamate receptor
Schmidtea mediterranea mk4.017349.00  
Schmidtea mediterranea mk4.001419.04   Putative metabotropic glutamate receptor
Schmidtea mediterranea mk4.009528.00   Putative metabotropic glutamate receptor
Schmidtea mediterranea mk4.015264.00   Putative metabotropic glutamate receptor
Schmidtea mediterranea mk4.001419.00  
Schmidtea mediterranea mk4.004608.01  
Schmidtea mediterranea mk4.000394.09   Putative metabotropic glutamate receptor
Schmidtea mediterranea mk4.007320.04  
Schmidtea mediterranea mk4.007320.01  

Essentiality

Sjp_0094810 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZC506.4 Caenorhabditis elegans slow growth wormbase
CELE_F45H11.4 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens glutamate receptor, metabotropic 6 Compounds References
Rattus norvegicus Metabotropic glutamate receptor 1 Compounds References
Rattus norvegicus Metabotropic glutamate receptor 2 Compounds References
Homo sapiens glutamate receptor, metabotropic 5 Compounds References
Mus musculus glutamate receptor, metabotropic 1 Compounds References
Rattus norvegicus Metabotropic glutamate receptor 8 Compounds References
Homo sapiens glutamate receptor, metabotropic 7 Compounds References
Mus musculus glutamate receptor, metabotropic 8 Compounds References
Homo sapiens glutamate receptor, metabotropic 8 Compounds References
Homo sapiens glutamate receptor, metabotropic 3 Compounds References
Homo sapiens glutamate receptor, metabotropic 4 Compounds References
Rattus norvegicus Metabotropic glutamate receptor 4 Compounds References
Rattus norvegicus Metabotropic glutamate receptor 6 Compounds References
Rattus norvegicus Metabotropic glutamate receptor 3 Compounds References
Homo sapiens glutamate receptor, metabotropic 2 Compounds References
Rattus norvegicus Metabotropic glutamate receptor 5 Compounds References
Rattus norvegicus Metabotropic glutamate receptor 7 Compounds References
Homo sapiens glutamate receptor, metabotropic 1 Compounds References
Mus musculus glutamate receptor, metabotropic 5 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0094810 (Schistosoma japonicum), hypothetical protein
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