Detailed view for Sjp_0204440

Basic information

TDR Targets ID: 976726
Schistosoma japonicum, IPR011009,Protein kinase-like;IPR010993,Sterile alpha motif homology;IPR000719,Protein kinase;IPR015779,ACK tyrosine protein ki
Source Database / ID:  Wormbase Parasite  

pI: 8.4546 | Length (AA): 226 | MW (Da): 25676 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131365)

Species Accession Gene Product
Brugia malayi Bm1_01945   Protein kinase domain containing protein
Caenorhabditis elegans CELE_B0302.1   Protein SID-3, isoform A
Drosophila melanogaster Dmel_CG14992   Activated Cdc42 kinase
Echinococcus granulosus EgrG_000558100   tyrosine protein kinase Btk29A
Echinococcus granulosus EgrG_000557900   activated cdc42 kinase 1
Echinococcus granulosus EgrG_000557500   activated cdc42 kinase 1
Echinococcus multilocularis EmuJ_000558100   protein KINase family member (kin 25)
Echinococcus multilocularis EmuJ_000557500   transfer RNA-Thr
Echinococcus multilocularis EmuJ_000557900   activated cdc42 kinase 1
Homo sapiens ENSG00000174292   tyrosine kinase, non-receptor, 1
Homo sapiens ENSG00000061938   tyrosine kinase, non-receptor, 2
Loa Loa (eye worm) LOAG_13013   hypothetical protein
Loa Loa (eye worm) LOAG_09800   hypothetical protein
Loa Loa (eye worm) LOAG_12423   hypothetical protein
Loa Loa (eye worm) LOAG_12539   hypothetical protein
Loa Loa (eye worm) LOAG_13386   hypothetical protein
Mus musculus ENSMUSG00000001583   tyrosine kinase, non-receptor, 1
Mus musculus ENSMUSG00000022791   tyrosine kinase, non-receptor, 2
Schistosoma japonicum Sjp_0204440   IPR011009,Protein kinase-like;IPR010993,Sterile alpha motif homology;IPR000719,Protein kinase;IPR015779,ACK tyrosine protein ki
Schistosoma japonicum Sjp_0204450   Activated CDC42 kinase 2, putative
Schistosoma mansoni Smp_164930   tyrosine kinase
Schmidtea mediterranea mk4.007964.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens tyrosine kinase, non-receptor, 2 Compounds References
Homo sapiens tyrosine kinase, non-receptor, 1 Compounds References
Mus musculus tyrosine kinase, non-receptor, 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0204440 (Schistosoma japonicum), IPR011009,Protein kinase-like;IPR010993,Sterile alpha motif homology;IPR000719,Protein kinase;IPR015779,ACK tyrosine protein ki
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