Detailed view for Sjp_0000030

Basic information

TDR Targets ID: 977452
Schistosoma japonicum, ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative
Source Database / ID:  Wormbase Parasite  

pI: 7.3312 | Length (AA): 294 | MW (Da): 32701 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00287   Sodium / potassium ATPase beta chain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005890   sodium:potassium-exchanging ATPase complex  
GO:0006814   sodium ion transport  
GO:0006813   potassium ion transport  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
22 293 3wgu (B) 13 300 31.00 0 1 1.07693 0.77
28 284 4xe5 (B) 19 289 34.00 0 0.88 1.04413 1.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131864)

Species Accession Gene Product
Caenorhabditis elegans CELE_C17E4.9   Protein NKB-1
Caenorhabditis elegans CELE_F55F3.3   Protein NKB-3
Drosophila melanogaster Dmel_CG8663   nervana 3
Drosophila melanogaster Dmel_CG9258   nervana 1
Echinococcus granulosus EgrG_001129000   sodium:potassium transporting ATPase subunit
Echinococcus granulosus EgrG_000413500   sodium:potassium dependent atpase beta subunit
Echinococcus granulosus EgrG_001129100   nervana 2
Echinococcus granulosus EgrG_000428400   sodium:potassium dependent atpase beta subunit
Echinococcus granulosus EgrG_000330900   nervana 2
Echinococcus multilocularis EmuJ_000428400   sodium:potassium dependent atpase beta subunit
Echinococcus multilocularis EmuJ_001129100   nervana 2
Echinococcus multilocularis EmuJ_000413500   sodium:potassium dependent atpase beta subunit
Echinococcus multilocularis EmuJ_000330900   nervana 2
Echinococcus multilocularis EmuJ_001129000   sodium:potassium transporting ATPase subunit
Homo sapiens ENSG00000143153   ATPase, Na+/K+ transporting, beta 1 polypeptide
Loa Loa (eye worm) LOAG_05647   hypothetical protein
Loa Loa (eye worm) LOAG_13887   hypothetical protein
Mus musculus ENSMUSG00000026576   ATPase, Na+/K+ transporting, beta 1 polypeptide
Onchocerca volvulus OVOC3232  
Schistosoma japonicum Sjp_0000030   ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative
Schistosoma japonicum Sjp_0304170   ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative
Schistosoma japonicum Sjp_0032120   Sodium/potassium-transporting ATPase subunit beta-1, putative
Schistosoma mansoni Smp_160290   sodium/potassium-dependent atpase beta subunit
Schistosoma mansoni Smp_033550   transmemberane protein
Schistosoma mansoni Smp_124240   sodium/potassium-dependent atpase beta subunit
Schmidtea mediterranea mk4.003662.01  
Schmidtea mediterranea mk4.004242.00  
Schmidtea mediterranea mk4.004242.04   Putative sodium/potassium-transporting ATPase subunit beta
Schmidtea mediterranea mk4.000996.02  
Schmidtea mediterranea mk4.000266.02   Putative sodium/potassium-dependent atpase beta subunit
Schmidtea mediterranea mk4.003485.01  
Schmidtea mediterranea mk4.014842.00  

Essentiality

Sjp_0000030 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C17E4.9 Caenorhabditis elegans embryonic lethal wormbase
CELE_C17E4.9 Caenorhabditis elegans larval arrest wormbase
CELE_C17E4.9 Caenorhabditis elegans slow growth wormbase
CELE_C17E4.9 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ATPase, Na+/K+ transporting, beta 1 polypeptide Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Sus scrofa Potassium-transporting ATPase 290 aa 23.6% 258 aa Compounds References
Sus scrofa Potassium-transporting ATPase beta chain 290 aa 23.6% 258 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0000030 (Schistosoma japonicum), ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative
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