Detailed view for Sjp_0079570

Basic information

TDR Targets ID: 977674
Schistosoma japonicum, IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing
Source Database / ID:  Wormbase Parasite  

pI: 4.6595 | Length (AA): 309 | MW (Da): 35627 | Paralog Number: 4

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0004114   3',5'-cyclic-nucleotide phosphodiesterase activity  
GO:0007165   signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
204 293 1so2 (A) 659 752 34.00 0.002 0.78 0.708708 -0.67
204 308 1taz (A) 148 257 29.00 0.000014 0.5 0.725509 -0.86
205 301 3ecm (A) 483 579 29.00 0.00000015 0.82 0.746535 -0.71

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128242)

Species Accession Gene Product
Brugia malayi Bm1_53400   Probable 3',5'-cyclic phosphodiesterase R153.1, putative
Caenorhabditis elegans CELE_R153.1   Protein PDE-4, isoform F
Cryptosporidium hominis Chro.60068   hypothetical protein
Cryptosporidium parvum cgd6_500   membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein
Drosophila melanogaster Dmel_CG32498   dunce
Echinococcus granulosus EgrG_000643700   cAMP specific 3'5' cyclic phosphodiesterase
Echinococcus granulosus EgrG_000162200   cAMP specific 3'5' cyclic phosphodiesterase
Echinococcus granulosus EgrG_000162300   cAMP specific 3'5' cyclic phosphodiesterase
Echinococcus multilocularis EmuJ_000643700   cAMP specific 3',5' cyclic phosphodiesterase
Echinococcus multilocularis EmuJ_000162200   cAMP specific 3',5' cyclic phosphodiesterase
Echinococcus multilocularis EmuJ_000162300   cAMP specific 3',5' cyclic phosphodiesterase
Giardia lamblia GL50803_14058   CAMP-specific 3,5-cyclic phosphodiesterase 4B
Homo sapiens ENSG00000065989   phosphodiesterase 4A, cAMP-specific
Homo sapiens ENSG00000184588   phosphodiesterase 4B, cAMP-specific
Homo sapiens ENSG00000113448   phosphodiesterase 4D, cAMP-specific
Homo sapiens ENSG00000105650   phosphodiesterase 4C, cAMP-specific
Loa Loa (eye worm) LOAG_07841   hypothetical protein
Loa Loa (eye worm) LOAG_15725   cyclic AMP specific phosphodiesterase PDE4D5A
Mus musculus ENSMUSG00000031842   phosphodiesterase 4C, cAMP specific
Mus musculus ENSMUSG00000032177   phosphodiesterase 4A, cAMP specific
Mus musculus 238871   phosphodiesterase 4D, cAMP specific
Mus musculus ENSMUSG00000028525   phosphodiesterase 4B, cAMP specific
Neospora caninum NCLIV_030330   cAMP-specific phosphodiesterase, putative
Schistosoma japonicum Sjp_0079570   IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing
Schistosoma japonicum Sjp_0111880   cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative
Schistosoma japonicum Sjp_0072560   cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative
Schistosoma japonicum Sjp_0121960   cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative
Schistosoma japonicum Sjp_0107930   cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative
Schistosoma mansoni Smp_134140   camp-specific 35-cyclic phosphodiesterase
Schmidtea mediterranea mk4.017180.00  
Schmidtea mediterranea mk4.017180.01  
Schmidtea mediterranea mk4.008328.01   Probable 3',5'-cyclic phosphodiesterase pde-4
Schmidtea mediterranea mk4.006977.01  
Schmidtea mediterranea mk4.011281.01   Probable 3',5'-cyclic phosphodiesterase pde-4
Schmidtea mediterranea mk4.011369.00  
Schmidtea mediterranea mk4.056175.00   Probable 3',5'-cyclic phosphodiesterase pde-4
Schmidtea mediterranea mk4.023548.01   Probable 3',5'-cyclic phosphodiesterase pde-4
Schmidtea mediterranea mk4.011369.01   Probable 3',5'-cyclic phosphodiesterase pde-4
Schmidtea mediterranea mk4.000577.06   Probable 3',5'-cyclic phosphodiesterase pde-4
Schmidtea mediterranea mk4.003650.00   Probable 3',5'-cyclic phosphodiesterase pde-4
Schmidtea mediterranea mk4.002563.07   Probable 3',5'-cyclic phosphodiesterase pde-4
Schmidtea mediterranea mk4.010659.00  
Schmidtea mediterranea mk4.023993.00  
Schmidtea mediterranea mk4.023548.00  
Toxoplasma gondii TGME49_229405   3'5'-cyclic nucleotide phosphodiesterase domain-containing protein

Essentiality

Sjp_0079570 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_229405 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Phosphodiesterase 4B Compounds References
Homo sapiens phosphodiesterase 4A, cAMP-specific Compounds References
Homo sapiens phosphodiesterase 4D, cAMP-specific Compounds References
Rattus norvegicus Phosphodiesterase 4D Compounds References
Mus musculus phosphodiesterase 4A, cAMP specific Compounds References
Homo sapiens phosphodiesterase 4B, cAMP-specific Compounds References
Homo sapiens phosphodiesterase 4C, cAMP-specific Compounds References
Sus scrofa Phosphodiesterase 4A Compounds References
Mus musculus phosphodiesterase 4B, cAMP specific Compounds References
Cavia porcellus cAMP-specific 3',5'-cyclic phosphodiesterase 4A Compounds References
Mus musculus phosphodiesterase 4C, cAMP specific Compounds References
Rattus norvegicus Phosphodiesterase 4 Compounds References
Mus musculus phosphodiesterase 4D, cAMP specific Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0079570 (Schistosoma japonicum), IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing
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