Detailed view for Sjp_0070740

Basic information

TDR Targets ID: 978013
Schistosoma japonicum, ko:K04364 growth factor receptor-binding protein 2, putative
Source Database / ID:  Wormbase Parasite  

pI: 5.3911 | Length (AA): 235 | MW (Da): 27127 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00017   SH2 domain
PF00018   SH3 domain
PF14604   Variant SH3 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 58 2a36 (A) 1 58 62.00 0 1 1.02276 -0.65
1 230 1gri (A) 1 213 51.00 0 1 1.44081 0.15
175 232 2k9g (A) 270 328 38.00 0 1 0.820763 -1.73
178 228 2ecz (A) 11 62 41.00 0.000074 1 0.829849 -1.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131257)

Species Accession Gene Product
Brugia malayi Bm1_39900   Sex muscle abnormal protein 5
Caenorhabditis elegans CELE_C14F5.5   Protein SEM-5
Drosophila melanogaster Dmel_CG6033   downstream of receptor kinase
Echinococcus granulosus EgrG_000587600   growth factor receptor bound protein 2
Echinococcus multilocularis EmuJ_000587600   growth factor receptor bound protein 2
Homo sapiens 10750   GRB2-related adaptor protein
Homo sapiens ENSG00000177885   growth factor receptor-bound protein 2
Loa Loa (eye worm) LOAG_05951   sex muscle abnormal protein 5
Mus musculus ENSMUSG00000004837   GRB2-related adaptor protein
Mus musculus ENSMUSG00000059923   growth factor receptor bound protein 2
Schistosoma japonicum Sjp_0303680   Growth factor receptor-bound protein 2, putative
Schistosoma japonicum Sjp_0070740   ko:K04364 growth factor receptor-binding protein 2, putative
Schistosoma mansoni Smp_062950   growth factor receptor-bound protein
Schistosoma mansoni Smp_044530   growth factor receptor-bound protein
Schmidtea mediterranea mk4.000703.00   Sex muscle abnormal protein 5
Schmidtea mediterranea mk4.007441.00   Sex muscle abnormal protein 5

Essentiality

Sjp_0070740 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C14F5.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_C14F5.5 Caenorhabditis elegans larval lethal wormbase
CELE_C14F5.5 Caenorhabditis elegans slow growth wormbase
CELE_C14F5.5 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens growth factor receptor-bound protein 2 Compounds References
Mus musculus growth factor receptor bound protein 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0070740 (Schistosoma japonicum), ko:K04364 growth factor receptor-binding protein 2, putative
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