Detailed view for Sjp_0095180

Basic information

TDR Targets ID: 978656
Schistosoma japonicum, ko:K04135 adrenergic receptor, alpha 1a, putative
Source Database / ID:  Wormbase Parasite  

pI: 8.665 | Length (AA): 495 | MW (Da): 56370 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00001   7 transmembrane receptor (rhodopsin family)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0004930   G-protein coupled receptor activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 81 3v2y (A) 30 92 29.00 0.00026 0.03 0.15713 2.05
42 381 4amj (A) 50 357 43.00 0 1 0.848959 0.38
42 382 2rh1 (A) 42 341 38.00 0 1 0.718983 0.4
42 382 3kj6 (A) 42 341 49.00 0 0.99 0.467983 1.8

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128924)

Species Accession Gene Product
Caenorhabditis elegans CELE_F16D3.7   Protein SER-5
Caenorhabditis elegans CELE_C52B11.3   Protein DOP-4
Drosophila melanogaster Dmel_CG18741   Dopamine 1-like receptor 2
Homo sapiens ENSG00000171873   adrenoceptor alpha 1D
Homo sapiens 147   adrenoceptor alpha 1B
Homo sapiens ENSG00000113749   histamine receptor H2
Mus musculus ENSMUSG00000034987   histamine receptor H2
Mus musculus ENSMUSG00000050541   adrenergic receptor, alpha 1b
Mus musculus 11550   adrenergic receptor, alpha 1d
Schistosoma japonicum Sjp_0026520   Alpha-1D adrenergic receptor, putative
Schistosoma japonicum Sjp_0095180   ko:K04135 adrenergic receptor, alpha 1a, putative
Schistosoma mansoni Smp_150180   amine GPCR
Schmidtea mediterranea mk4.000742.09   Dopamine receptor 4
Schmidtea mediterranea mk4.029836.00  
Schmidtea mediterranea mk4.011371.00   Dopamine receptor 4
Schmidtea mediterranea mk4.003202.01   Dopamine receptor 4
Schmidtea mediterranea mk4.012659.00   Dopamine receptor 4
Schmidtea mediterranea mk4.028983.00   Putative g-protein coupled receptor
Schmidtea mediterranea mk4.031359.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Alpha-1d adrenergic receptor Compounds References
Rattus norvegicus Alpha-1b adrenergic receptor Compounds References
Mus musculus adrenergic receptor, alpha 1d Compounds References
Mesocricetus auratus Alpha-1b adrenergic receptor Compounds References
Cavia porcellus Histamine H2 receptor Compounds References
Homo sapiens adrenoceptor alpha 1D Compounds References
Homo sapiens histamine receptor H2 Compounds References
Homo sapiens adrenoceptor alpha 1B Compounds References
Rattus norvegicus Histamine H2 receptor Compounds References
Mus musculus adrenergic receptor, alpha 1b Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Cavia porcellus Adenosine A2a receptor 409 aa 25.4% 453 aa Compounds References
Rattus norvegicus Serotonin 5a (5-HT5a) receptor 357 aa 32.2% 348 aa Compounds References
Canis lupus familiaris Somatostatin receptor subtype 3 425 aa 22.8% 395 aa Compounds References
Rattus norvegicus Orexin receptor 1 416 aa 27.2% 360 aa Compounds References
Bos taurus Dopamine receptor 446 aa 33.9% 398 aa Compounds References
Rattus norvegicus Bradykinin B2 receptor 396 aa 22.5% 347 aa Compounds References
Bos taurus Rhodopsin 348 aa 21.3% 380 aa Compounds References
Meriones unguiculatus Substance-P receptor 407 aa 22.8% 373 aa Compounds References
Rattus norvegicus Dopamine D1 receptor 446 aa 33.7% 407 aa Compounds References
Cavia porcellus Serotonin 4 (5-HT4) receptor 388 aa 35.3% 363 aa Compounds References
Rattus norvegicus Lysophosphatidic acid receptor Edg-7 354 aa 23.3% 343 aa Compounds References
Rattus norvegicus Serotonin 1f (5-HT1f) receptor 366 aa 32.2% 391 aa Compounds References
Sus scrofa Alpha-1A adrenergic receptor 466 aa 30.8% 442 aa Compounds References
Canis lupus familiaris Beta-3 adrenergic receptor 405 aa 33.8% 334 aa Compounds References
Sus scrofa Type-1 angiotensin II receptor 359 aa 23.4% 346 aa Compounds References
Rattus norvegicus Adenosine A2b receptor 332 aa 26.2% 359 aa Compounds References
Gallus gallus Adenosine A1 receptor 324 aa 25.9% 340 aa Compounds References
Oryctolagus cuniculus Bradykinin B2 receptor 367 aa 24.1% 348 aa Compounds References
Cavia porcellus Kappa opioid receptor 380 aa 23.3% 403 aa Compounds References
Mesocricetus auratus Beta-2 adrenergic receptor 418 aa 33.7% 356 aa Compounds References
Rattus norvegicus Thyrotropin-releasing hormone receptor 412 aa 24.2% 335 aa Compounds References
Bos taurus Dopamine D1 receptor 446 aa 33.9% 398 aa Compounds References
Macaca mulatta B1 bradykinin receptor 352 aa 21.0% 333 aa Compounds References
Rattus norvegicus Cannabinoid CB2 receptor 360 aa 23.8% 370 aa Compounds References
Rattus norvegicus Serotonin 4 (5-HT4) receptor 406 aa 33.3% 384 aa Compounds References
Rattus norvegicus Serotonin 1 (5-HT1) receptor 366 aa 32.2% 391 aa Compounds References
Oryctolagus cuniculus Neurokinin 2 receptor 384 aa 21.6% 357 aa Compounds References
Macaca mulatta Gonadotropin-releasing hormone receptor 59 aa 28.0% 50 aa Compounds References
Macaca mulatta Sphingosine 1-phosphate receptor 1 382 aa 25.1% 355 aa Compounds References
Rattus norvegicus Sphingosine 1-phosphate receptor 1 383 aa 25.9% 351 aa Compounds References
Rattus norvegicus Neuropeptide Y receptor type 2 381 aa 22.4% 353 aa Compounds References
Macaca fascicularis B1 bradykinin receptor 352 aa 21.0% 333 aa Compounds References
Rattus norvegicus Histamine H4 receptor 391 aa 24.4% 390 aa Compounds References
Sus scrofa Ghrelin receptor 366 aa 26.1% 349 aa Compounds References
Rattus norvegicus Nociceptin/mu opioid receptor 398 aa 22.7% 397 aa Compounds References
Rattus norvegicus Cholecystokinin A receptor 444 aa 28.6% 364 aa Compounds References
Cavia porcellus Beta-2 adrenergic receptor 418 aa 33.5% 385 aa Compounds References
Rattus norvegicus Neurokinin 2 receptor 390 aa 22.5% 364 aa Compounds References
Bos taurus Angiotensin II type 1a (AT-1a) receptor 359 aa 24.9% 346 aa Compounds References
Bos taurus Alpha-1a adrenergic receptor 466 aa 31.4% 446 aa Compounds References
Rattus norvegicus Dopamine receptor 475 aa 34.2% 398 aa Compounds References
Rattus norvegicus Oxytocin receptor 388 aa 22.9% 349 aa Compounds References
Sus scrofa Serotonin 1d (5-HT1d) receptor 291 aa 32.2% 323 aa Compounds References
Rattus norvegicus Adenosine A2 receptor 410 aa 28.3% 346 aa Compounds References
Rattus norvegicus Gonadotropin-releasing hormone receptor 327 aa 21.6% 343 aa Compounds References
Rattus norvegicus Adenosine A3 receptor 320 aa 25.4% 358 aa Compounds References
Rattus norvegicus Ghrelin receptor 364 aa 26.6% 349 aa Compounds References
Cricetulus griseus 5-hydroxytryptamine receptor 1B 386 aa 33.1% 353 aa Compounds References
Rattus norvegicus Galanin receptor 1 346 aa 23.4% 381 aa Compounds References
Rattus norvegicus Beta-3 adrenergic receptor 400 aa 34.7% 343 aa Compounds References
Rattus norvegicus Gastrin releasing peptide receptor 384 aa 23.6% 398 aa Compounds References
Cavia porcellus Mu-opioid receptor 400 aa 22.1% 390 aa Compounds References
Cavia porcellus Bradykinin B2 receptor 372 aa 22.7% 335 aa Compounds References
Bos taurus Uncharacterized protein 403 aa 28.6% 343 aa Compounds References
Rattus norvegicus Serotonin 1b (5-HT1b) receptor 386 aa 34.7% 352 aa Compounds References
Bos taurus Beta-2 adrenergic receptor 418 aa 35.6% 376 aa Compounds References
Macaca mulatta Mu-type opioid receptor 400 aa 22.5% 391 aa Compounds References
Rattus norvegicus Kappa opioid receptor 380 aa 23.5% 408 aa Compounds References
Gorilla gorilla Serotonin 1b (5-HT1b) receptor 390 aa 33.3% 409 aa Compounds References
Rattus norvegicus Serotonin 1B/1D receptor 374 aa 33.7% 359 aa Compounds References
Oryctolagus cuniculus Alpha-1a adrenergic receptor 466 aa 30.7% 446 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 1 332 aa 30.5% 344 aa Compounds References
Carassius auratus Dopamine D1 receptor 363 aa 34.9% 367 aa Compounds References
Canis lupus familiaris Adenosine receptor A3 314 aa 25.1% 354 aa Compounds References
Rattus norvegicus Adenosine A2a receptor 410 aa 28.3% 346 aa Compounds References
Sus scrofa Serotonin 4 (5-HT4) receptor 402 aa 31.7% 394 aa Compounds References
Macaca mulatta Beta-3 adrenergic receptor 418 aa 34.2% 392 aa Compounds References
Rattus norvegicus Galanin receptor 2 372 aa 24.4% 352 aa Compounds References
Bos taurus Cholecystokinin B receptor 454 aa 25.0% 424 aa Compounds References
Rattus norvegicus Neurokinin 1 receptor 407 aa 22.8% 373 aa Compounds References
Cavia porcellus Nociceptin receptor 370 aa 23.5% 362 aa Compounds References
Rattus norvegicus Metastin receptor 396 aa 23.7% 355 aa Compounds References
Rattus norvegicus Serotonin 2 (5-HT2) receptor 460 aa 31.1% 405 aa Compounds References
Gallus gallus Oxytocin-like receptor 391 aa 22.9% 398 aa Compounds References
Rattus norvegicus Neuropeptide Y receptor type 4 375 aa 23.9% 401 aa Compounds References
Cavia porcellus mu/kappa opioid receptor 380 aa 23.3% 403 aa Compounds References
Xenopus laevis Melatonin receptor 1C 420 aa 22.1% 362 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 7b 358 aa 30.9% 343 aa Compounds References
Rattus norvegicus Somatostatin receptor 2 369 aa 25.3% 375 aa Compounds References
Canis lupus familiaris Beta-2 adrenergic receptor 415 aa 33.9% 357 aa Compounds References
Macaca fascicularis Melanin-concentrating hormone receptor 1 249 aa 24.1% 282 aa Compounds References
Macaca mulatta Trace amine-associated receptor 1 338 aa 30.5% 344 aa Compounds References
Bos taurus Adenosine receptor A3 317 aa 27.0% 385 aa Compounds References
Rattus norvegicus Melanin-concentrating hormone receptor 1 360 aa 25.4% 358 aa Compounds References
Canis familiaris 5-hydroxytryptamine receptor 2C 458 aa 31.8% 377 aa Compounds References
Rattus norvegicus Vasopressin V1a receptor 424 aa 24.9% 373 aa Compounds References
Cavia porcellus Cholecystokinin A receptor 430 aa 27.3% 373 aa Compounds References
Gallus gallus Melatonin receptor 346 aa 23.2% 349 aa Compounds References
Rattus norvegicus Neuropeptide FF receptor 2 417 aa 23.3% 352 aa Compounds References
Cavia porcellus Serotonin 1d (5-HT1d) receptor 376 aa 32.6% 365 aa Compounds References
Rattus norvegicus Lysophosphatidic acid receptor Edg-2 364 aa 23.9% 356 aa Compounds References
Sus scrofa Endothelin receptor ET-B 443 aa 23.5% 392 aa Compounds References
Macaca fascicularis C-C chemokine receptor type 3 355 aa 20.6% 326 aa Compounds References
Rattus norvegicus Dopamine D5 receptor 475 aa 34.2% 398 aa Compounds References
Rattus norvegicus Neuromedin B receptor 390 aa 26.2% 362 aa Compounds References
Rattus norvegicus Adrenergic receptor beta 400 aa 34.7% 343 aa Compounds References
Cavia porcellus Neurokinin 2 receptor 402 aa 22.6% 358 aa Compounds References
Rattus norvegicus Bombesin receptor subtype-3 399 aa 23.4% 372 aa Compounds References
Canis lupus familiaris Sphingosine-1-phosphate receptor 1 381 aa 24.6% 354 aa Compounds References
Cavia porcellus Histamine H4 receptor 389 aa 25.1% 391 aa Compounds References
Ovis aries Ghrelin receptor 366 aa 25.5% 349 aa Compounds References
Cavia porcellus Mu opioid receptor 98 aa 30.3% 89 aa Compounds References
Rattus norvegicus Lysophosphatidic acid receptor 1/lysophosphatidic acid receptor 3 354 aa 23.3% 343 aa Compounds References
Oryctolagus cuniculus Growth hormone secretagogue receptor type 1 366 aa 26.6% 349 aa Compounds References
Rattus norvegicus Cholecystokinin receptor 444 aa 28.6% 364 aa Compounds References
Cavia porcellus Neurokinin 1 receptor 407 aa 23.1% 373 aa Compounds References
Rattus norvegicus Somatostatin receptor 1 391 aa 23.6% 416 aa Compounds References
Rattus norvegicus Mu opioid receptor 398 aa 22.7% 397 aa Compounds References
Canis lupus familiaris Bradykinin B1 receptor 350 aa 23.3% 352 aa Compounds References
Rattus norvegicus Serotonin 1d (5-HT1d) receptor 374 aa 33.7% 359 aa Compounds References
Rattus norvegicus Sphingosine 1-phosphate receptor 2 352 aa 24.9% 349 aa Compounds References
Rattus norvegicus Serotonin 2c (5-HT2c) receptor 460 aa 31.1% 405 aa Compounds References
Rattus norvegicus Protein Gpr39 298 aa 25.5% 271 aa Compounds References
Chlorocebus aethiops Dopamine D3 receptor 400 aa 28.4% 394 aa Compounds References
Cricetulus griseus Prokineticin receptor 2 391 aa 22.6% 376 aa Compounds References
Rattus norvegicus Nociceptin receptor 367 aa 24.2% 396 aa Compounds References
Rattus norvegicus C-C chemokine receptor type 3 359 aa 20.4% 343 aa Compounds References
Rattus norvegicus Serotonin 6 (5-HT6) receptor 436 aa 31.2% 352 aa Compounds References
Microtus ochrogaster Vasopressin V1a receptor 420 aa 23.8% 390 aa Compounds References
Danio rerio Mu opioid receptor-like OR2 384 aa 22.2% 360 aa Compounds References
Macaca fascicularis G-protein coupled receptor 119 335 aa 22.9% 340 aa Compounds References
Rattus norvegicus Melatonin receptor 1B 364 aa 21.8% 353 aa Compounds References
Bos taurus 5-hydroxytryptamine 1D receptor 119 aa 35.6% 104 aa Compounds References
Rattus norvegicus Alpha-1a adrenergic receptor 466 aa 31.2% 443 aa Compounds References
Sus scrofa Dopamine D1 receptor 446 aa 33.7% 406 aa Compounds References
Bos taurus Neurokinin 2 receptor 384 aa 24.0% 379 aa Compounds References
Cricetulus griseus 5-hydroxytryptamine receptor 422 aa 29.5% 448 aa Compounds References
Rattus norvegicus Serotonin 5b (5-HT5b) receptor 370 aa 31.5% 337 aa Compounds References
Mesocricetus auratus Neurokinin 2 receptor 384 aa 21.1% 356 aa Compounds References
Canis lupus familiaris Uncharacterized protein 335 aa 21.8% 317 aa Compounds References
Rattus norvegicus Thyrotropin-releasing hormone receptor 2 352 aa 23.5% 298 aa Compounds References
Rattus norvegicus Adenosine receptor 332 aa 26.2% 359 aa Compounds References
Macaca mulatta C-C chemokine receptor type 3 355 aa 19.9% 326 aa Compounds References
Oryctolagus cuniculus Adenosine A3 receptor 319 aa 24.9% 353 aa Compounds References
Gallus gallus Melatonin receptor 1B 289 aa 21.8% 317 aa Compounds References
Bos taurus Mu opioid receptor 401 aa 23.4% 385 aa Compounds References
Rattus norvegicus Serotonin (5-HT) receptor 386 aa 34.7% 352 aa Compounds References
Rattus norvegicus Neuropeptide Y receptor type 1 382 aa 23.5% 345 aa Compounds References
Rattus norvegicus Beta-2 adrenergic receptor 418 aa 34.6% 358 aa Compounds References
Rattus norvegicus Serotonin 1a (5-HT1a) receptor 422 aa 29.7% 448 aa Compounds References
Macaca mulatta Melanin-concentrating hormone receptor 1 388 aa 24.5% 388 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0095180 (Schistosoma japonicum), ko:K04135 adrenergic receptor, alpha 1a, putative
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