Detailed view for Sjp_0011140

Basic information

TDR Targets ID: 979030
Schistosoma japonicum, ko:K07003 Niemann Pick type C1, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.9051 | Length (AA): 630 | MW (Da): 70018 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 2

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF16414   Niemann-Pick C1 N terminus

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Lysosome (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 80 1sgl (A) 5 64 38.00 0.088 0.13 0.0758776 2.41
16 243 3qnt (A) 25 265 30.00 0 1 0.69098 -0.75
22 241 3gkj (A) 23 247 30.00 0 1 0.696262 -0.83
238 291 2cr5 (A) 2 52 29.00 0 0.08 0.113851 1.64
340 627 5u74 (A) 334 613 37.00 0 1 0.81737 0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128206)

Species Accession Gene Product
Arabidopsis thaliana AT4G38350   Patched family protein
Arabidopsis thaliana AT1G42470   Patched family protein
Brugia malayi Bm1_30915   Niemann-Pick C1 protein precursor
Candida albicans CaO19.7242   potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home
Caenorhabditis elegans CELE_F02E8.6   Protein NCR-1
Dictyostelium discoideum DDB_G0269158   Niemann-Pick C type protein
Dictyostelium discoideum DDB_G0276657   hypothetical protein
Drosophila melanogaster Dmel_CG12092   Niemann-Pick type C-1b
Drosophila melanogaster Dmel_CG5722   Niemann-Pick type C-1a
Echinococcus granulosus EgrG_001107950   Niemann Pick C1 protein
Echinococcus granulosus EgrG_000936200   expressed conserved protein
Echinococcus granulosus EgrG_001107700   Niemann Pick C1 protein
Entamoeba histolytica EHI_080220   Niemann-Pick C1 protein, putative
Echinococcus multilocularis EmuJ_000936200   expressed conserved protein
Echinococcus multilocularis EmuJ_001107700   Niemann Pick C1 protein
Echinococcus multilocularis EmuJ_001107950   Niemann Pick C1 protein
Homo sapiens ENSG00000141458   Niemann-Pick disease, type C1
Homo sapiens ENSG00000015520   NPC1-like 1
Loa Loa (eye worm) LOAG_02190   hypothetical protein
Loa Loa (eye worm) LOAG_02191   hypothetical protein
Mus musculus ENSMUSG00000024413   Niemann-Pick type C1
Mus musculus ENSMUSG00000020447   NPC1-like 1
Oryza sativa 9266400   Os04g0563801
Saccharomyces cerevisiae YPL006W   Ncr1p
Schistosoma japonicum Sjp_0011140   ko:K07003 Niemann Pick type C1, putative
Schistosoma japonicum Sjp_0312570   Niemann-Pick C1 protein precursor, putative
Schistosoma japonicum Sjp_0102650   Niemann-Pick C1 protein precursor, putative
Schistosoma mansoni Smp_039130   niemann-pick C1 (NPC1)
Schmidtea mediterranea mk4.005786.01   NUCB1
Schmidtea mediterranea mk4.001362.03  
Schmidtea mediterranea mk4.006636.01   NUCB1
Schmidtea mediterranea mk4.009465.00   NUCB1
Schmidtea mediterranea mk4.014936.00   NUCB1
Schmidtea mediterranea mk4.001362.05  
Schmidtea mediterranea mk4.002617.01  
Schmidtea mediterranea mk4.001362.04  
Schmidtea mediterranea mk4.001362.02  

Essentiality

Sjp_0011140 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F02E8.6 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Canis lupus familiaris Niemann-Pick C1-like 1 protein Compounds References
Homo sapiens Niemann-Pick disease, type C1 Compounds References
Homo sapiens NPC1-like 1 Compounds References
Macaca mulatta Niemann-Pick C1-like 1 protein Compounds References
Rattus norvegicus Niemann-Pick C1-like protein 1 Compounds References
Mus musculus NPC1-like 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0011140 (Schistosoma japonicum), ko:K07003 Niemann Pick type C1, putative
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