Detailed view for Sjp_0035100

Basic information

TDR Targets ID: 979043
Schistosoma japonicum, ko:K04527 insulin receptor, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.2224 | Length (AA): 805 | MW (Da): 91112 | Paralog Number: 5

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07714   Protein tyrosine kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
217 302 1wj6 (A) 3 84 34.00 0.19 0.33 0.301565 0.13
351 797 2ptk (A) 148 522 34.00 0 1 0.52107 0.85
457 796 3lw0 (A) 988 1271 45.00 0 1 0.687986 0.15
457 795 5hhw (A) 1012 1294 45.00 0 1 0.732742 0.09
659 793 2rei (A) 742 892 34.00 0 1 0.61761 -0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129857)

Species Accession Gene Product
Brugia malayi Bm1_03245   Protein kinase domain containing protein
Brugia malayi Bm1_19395   Protein kinase domain containing protein
Caenorhabditis elegans CELE_Y55D5A.5   Protein DAF-2, isoform B
Drosophila melanogaster Dmel_CG18402   Insulin-like receptor
Echinococcus granulosus EgrG_000981300   insulin growth factor 1 receptor beta
Echinococcus granulosus EgrG_000962900   insulin receptor
Echinococcus multilocularis EmuJ_000981300   insulin growth factor 1 receptor beta
Echinococcus multilocularis EmuJ_000962900   insulin receptor
Homo sapiens ENSG00000027644   insulin receptor-related receptor
Homo sapiens ENSG00000171105   insulin receptor
Homo sapiens ENSG00000140443   insulin-like growth factor 1 receptor
Loa Loa (eye worm) LOAG_09113   TK/INSR protein kinase
Loa Loa (eye worm) LOAG_05521   hypothetical protein
Mus musculus ENSMUSG00000005534   insulin receptor
Mus musculus ENSMUSG00000005640   insulin receptor-related receptor
Mus musculus 16001   insulin-like growth factor I receptor
Schistosoma japonicum Sjp_0212920   Insulin-like peptide receptor precursor, putative
Schistosoma japonicum Sjp_0070030   ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative
Schistosoma japonicum Sjp_0035100   ko:K04527 insulin receptor, putative
Schistosoma japonicum Sjp_0070010   IPR000494,EGF receptor, L domain,domain-containing
Schistosoma japonicum Sjp_0069990   IPR008957,Fibronectin, type III-like fold,domain-containing
Schistosoma japonicum Sjp_0080940   Insulin-like peptide receptor precursor, putative
Schistosoma mansoni Smp_009990   tyrosine kinase
Schistosoma mansoni Smp_074030   tyrosine kinase
Schmidtea mediterranea mk4.003094.00   Insulin receptor-like 1 protein
Schmidtea mediterranea mk4.003094.03  
Schmidtea mediterranea mk4.004577.08  

Essentiality

Sjp_0035100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y55D5A.5 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus insulin receptor Compounds References
Rattus norvegicus Insulin receptor Compounds References
Homo sapiens insulin-like growth factor 1 receptor Compounds References
Mus musculus insulin-like growth factor I receptor Compounds References
Rattus norvegicus Insulin-like growth factor 1 receptor Compounds References
Homo sapiens insulin receptor Compounds References
Homo sapiens insulin receptor-related receptor Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Patiria pectinifera Cdc2 300 aa 22.5% 258 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 23.1% 260 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 32.2% 227 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 23.5% 268 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0035100 (Schistosoma japonicum), ko:K04527 insulin receptor, putative
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