Detailed view for Sjp_0060730

Basic information

TDR Targets ID: 979177
Schistosoma japonicum, ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.3429 | Length (AA): 769 | MW (Da): 86274 | Paralog Number: 3

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 12

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00209   Sodium:neurotransmitter symporter family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0005328   neurotransmitter:sodium symporter activity  
GO:0006836   neurotransmitter transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 528 4xp4 (A) 36 583 38.00 0.00000000012 1 1.18649 -0.89
671 739 2n72 (A) 1 69 17.00 0 0.02 0.386444 -1.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128673)

Species Accession Gene Product
Brugia malayi Bm1_30215   Sodium:neurotransmitter symporter family protein
Caenorhabditis elegans CELE_M01G5.5   Protein SNF-6
Drosophila melanogaster Dmel_CG5549   CG5549 gene product from transcript CG5549-RB
Drosophila melanogaster Dmel_CG7075   Neurotransmitter transporter-like
Echinococcus granulosus EgrG_000219900   sodium and chloride dependent glycine
Echinococcus granulosus EgrG_000220200   sodium and chloride dependent glycine
Echinococcus multilocularis EmuJ_000220200   sodium and chloride dependent glycine
Echinococcus multilocularis EmuJ_000219900   sodium and chloride dependent glycine
Homo sapiens 9152   solute carrier family 6 (neurotransmitter transporter), member 5
Homo sapiens ENSG00000196517   solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Homo sapiens ENSG00000268104   solute carrier family 6 (amino acid transporter), member 14
Homo sapiens ENSG00000011083   solute carrier family 6 (neurotransmitter transporter), member 7
Loa Loa (eye worm) LOAG_08466   Sodium:neurotransmitter symporter family protein
Loa Loa (eye worm) LOAG_13792   hypothetical protein
Loa Loa (eye worm) LOAG_04387   hypothetical protein
Mus musculus ENSMUSG00000028542   solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Mus musculus ENSMUSG00000031089   solute carrier family 6 (neurotransmitter transporter), member 14
Mus musculus ENSMUSG00000039728   solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Mus musculus ENSMUSG00000052026   solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
Schistosoma japonicum Sjp_0082830   Sodium- and chloride-dependent glycine transporter 1, putative
Schistosoma japonicum Sjp_0097740   Sodium- and chloride-dependent glycine transporter 1, putative
Schistosoma japonicum Sjp_0306210   Sodium-dependent proline transporter, putative
Schistosoma japonicum Sjp_0060730   ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative
Schistosoma mansoni Smp_131890   sodium/chloride dependent transporter
Schistosoma mansoni Smp_028690   sodium/chloride dependent transporter
Schmidtea mediterranea mk4.007536.01  
Schmidtea mediterranea mk4.002112.07  
Schmidtea mediterranea mk4.000711.05  
Schmidtea mediterranea mk4.001642.06  
Schmidtea mediterranea mk4.004097.00   Neutral alpha-glucosidase C
Schmidtea mediterranea mk4.000035.15  
Schmidtea mediterranea mk4.000377.05  
Schmidtea mediterranea mk4.000377.02  
Schmidtea mediterranea mk4.001658.10  
Schmidtea mediterranea mk4.000233.05  
Schmidtea mediterranea mk4.001225.07  
Schmidtea mediterranea mk4.029825.00  
Schmidtea mediterranea mk4.007536.02  
Schmidtea mediterranea mk4.002901.00  
Schmidtea mediterranea mk4.002713.07  
Schmidtea mediterranea mk4.000233.03  
Schmidtea mediterranea mk4.000035.14  
Schmidtea mediterranea mk4.000614.12  
Schmidtea mediterranea mk4.000035.16  
Schmidtea mediterranea mk4.029522.00  
Schmidtea mediterranea mk4.007350.00  
Schmidtea mediterranea mk4.001658.11  
Schmidtea mediterranea mk4.002713.05  
Schmidtea mediterranea mk4.001658.06   Sodium- and chloride-dependent betaine transporter
Schmidtea mediterranea mk4.010383.00  
Schmidtea mediterranea mk4.013977.01  
Schmidtea mediterranea mk4.002112.02  
Schmidtea mediterranea mk4.022484.00   Sodium- and chloride-dependent GABA transporter 1
Schmidtea mediterranea mk4.004288.00  
Schmidtea mediterranea mk4.001225.09  
Schmidtea mediterranea mk4.009326.01  
Schmidtea mediterranea mk4.004465.00  
Schmidtea mediterranea mk4.001871.00   Sodium-dependent acetylcholine transporter
Schmidtea mediterranea mk4.001225.08  
Schmidtea mediterranea mk4.010173.00  
Schmidtea mediterranea mk4.000233.01  
Schmidtea mediterranea mk4.026082.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter, glycine), member 9 Compounds References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 7 Compounds References
Bos taurus Sodium- and chloride-dependent glycine transporter 1 Compounds References
Rattus norvegicus Glycine transporter 2 Compounds References
Rattus norvegicus Glycine transporter 1 Compounds References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 5 Compounds References
Mus musculus solute carrier family 6 (neurotransmitter transporter, glycine), member 9 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus GABA transporter 2 602 aa 41.9% 501 aa Compounds References
Rattus norvegicus Norepinephrine transporter 597 aa 39.7% 501 aa Compounds References
Rattus norvegicus Serotonin transporter 630 aa 36.2% 520 aa Compounds References
Macaca mulatta Transporter 620 aa 39.7% 509 aa Compounds References
Rattus norvegicus GABA transporter 1 599 aa 38.8% 529 aa Compounds References
Rattus norvegicus Transporter 617 aa 39.7% 501 aa Compounds References
Rattus norvegicus Creatine transporter 635 aa 41.8% 541 aa Compounds References
Macaca fascicularis Dopamine transporter 620 aa 39.7% 509 aa Compounds References
Rattus norvegicus Dopamine transporter 619 aa 40.1% 509 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Sjp_0060730 (Schistosoma japonicum), ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative
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