Detailed view for Sjp_0301160

Basic information

TDR Targets ID: 979184
Schistosoma japonicum, ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative
Source Database / ID:  Wormbase Parasite  

pI: 6.8494 | Length (AA): 562 | MW (Da): 62311 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00171   Aldehyde dehydrogenase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016620   oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor  
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131437)

Species Accession Gene Product
Brugia malayi Bm1_28330   aldehyde dehydrogenase
Caenorhabditis elegans CELE_Y69F12A.2   Protein ALH-12, isoform B
Caenorhabditis elegans CELE_F42G9.5   Protein ALH-11, isoform B
Escherichia coli b0312   betaine aldehyde dehydrogenase, NAD-dependent
Echinococcus granulosus EgrG_001099300   Mitochondrial 28S ribosomal protein S29
Echinococcus multilocularis EmuJ_001099300   Mitochondrial 28S ribosomal protein S29
Homo sapiens ENSG00000143149   aldehyde dehydrogenase 9 family, member A1
Loa Loa (eye worm) LOAG_02927   aldehyde dehydrogenase
Mus musculus ENSMUSG00000026687   aldehyde dehydrogenase 9, subfamily A1
Schistosoma japonicum Sjp_0037730   Mitochondrial 28S ribosomal protein S29, putative
Schistosoma japonicum Sjp_0301160   ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative
Schistosoma mansoni Smp_126130   hypothetical protein
Schmidtea mediterranea mk4.007673.00   4-trimethylaminobutyraldehyde dehydrogenase
Schmidtea mediterranea mk4.014616.00  
Schmidtea mediterranea mk4.018336.01   4-trimethylaminobutyraldehyde dehydrogenase
Schmidtea mediterranea mk4.009807.01   4-trimethylaminobutyraldehyde dehydrogenase
Schmidtea mediterranea mk4.026744.00  

Essentiality

Sjp_0301160 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0312 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Aldehyde dehydrogenase, cytosolic 1 501 aa 37.8% 466 aa Compounds References
Rattus norvegicus Aldehyde dehydrogenase 519 aa 37.2% 470 aa Compounds References
Rattus norvegicus Aldehyde dehydrogenase 1A1 501 aa 37.1% 466 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0301160 (Schistosoma japonicum), ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative
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