Detailed view for Sjp_0012180

Basic information

TDR Targets ID: 979314
Schistosoma japonicum, ko:K09639 transmembrane protease, serine 8, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.29 | Length (AA): 485 | MW (Da): 53879 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00057   Low-density lipoprotein receptor domain class A
PF00089   Trypsin
PF00431   CUB domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0004252   serine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
189 222 3dpr (E) 4 39 50.00 0 0.27 0.432048 0.88
189 222 1ajj (A) 6 39 47.00 0.00011 0.8 0.576248 0.34
193 481 2xrc (A) 246 552 37.00 0 1 0.671107 0.76
250 484 4dgj (A) 1 234 37.00 0 1 1.01554 -1.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126639)

Species Accession Gene Product
Brugia malayi Bm1_19535   Trypsin family protein
Caenorhabditis elegans CELE_ZK546.15   Protein TRY-1
Drosophila melanogaster Dmel_CG17571   CG17571 gene product from transcript CG17571-RB
Drosophila melanogaster Dmel_CG11836   CG11836 gene product from transcript CG11836-RB
Drosophila melanogaster Dmel_CG4386   CG4386 gene product from transcript CG4386-RA
Drosophila melanogaster Dmel_CG12350   CG12350 gene product from transcript CG12350-RA
Drosophila melanogaster Dmel_CG18444   alphaTrypsin
Drosophila melanogaster Dmel_CG30031   CG30031 gene product from transcript CG30031-RA
Drosophila melanogaster Dmel_CG12351   deltaTrypsin
Drosophila melanogaster Dmel_CG12385   thetaTrypsin
Drosophila melanogaster Dmel_CG30028   gammaTrypsin
Drosophila melanogaster Dmel_CG4316   Stubble
Drosophila melanogaster Dmel_CG18735   CG18735 gene product from transcript CG18735-RA
Drosophila melanogaster Dmel_CG4812   CG4812 gene product from transcript CG4812-RA
Drosophila melanogaster Dmel_CG9564   Trypsin 29F
Drosophila melanogaster Dmel_CG3355   CG3355 gene product from transcript CG3355-RB
Drosophila melanogaster Dmel_CG18211   betaTrypsin
Drosophila melanogaster Dmel_CG4613   CG4613 gene product from transcript CG4613-RC
Drosophila melanogaster Dmel_CG30025   CG30025 gene product from transcript CG30025-RA
Drosophila melanogaster Dmel_CG18681   epsilonTrypsin
Homo sapiens ENSG00000275896   protease, serine, 2 (trypsin 2)
Homo sapiens 102725325   putative trypsin-6-like
Homo sapiens ENSG00000204983   protease, serine, 1 (trypsin 1)
Homo sapiens ENSG00000010438   protease, serine, 3
Loa Loa (eye worm) LOAG_16157   hypothetical protein
Loa Loa (eye worm) LOAG_10674   hypothetical protein
Mus musculus ENSMUSG00000056399   protease, serine 34
Mus musculus ENSMUSG00000029882   RIKEN cDNA 2210010C04 gene
Mus musculus ENSMUSG00000054106   trypsin 4
Mus musculus ENSMUSG00000036938   trypsin 5
Mus musculus ENSMUSG00000071517   predicted gene 10334
Mus musculus ENSMUSG00000058119   predicted gene 5771
Mus musculus ENSMUSG00000071519   protease, serine 3
Mus musculus ENSMUSG00000062751   protease, serine 1 (trypsin 1)
Mus musculus ENSMUSG00000071521   trypsin 10
Mus musculus ENSMUSG00000057163   protease, serine 2
Onchocerca volvulus OVOC11330  
Onchocerca volvulus OVOC11328  
Schistosoma japonicum Sjp_0208500   ko:K09639 transmembrane protease, serine 8, putative
Schistosoma japonicum Sjp_0012180   ko:K09639 transmembrane protease, serine 8, putative
Schistosoma mansoni Smp_030350   subfamily S1A unassigned peptidase (S01 family)
Schistosoma mansoni Smp_129230   subfamily S1A unassigned peptidase (S01 family)

Essentiality

Sjp_0012180 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZK546.15 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protease, serine, 1 (trypsin 1) Compounds References
Homo sapiens protease, serine, 2 (trypsin 2) Compounds References
Rattus norvegicus Anionic trypsin-1 Compounds References
Rattus norvegicus Trypsin II Compounds References
Sus scrofa Trypsin Compounds References
Homo sapiens protease, serine, 3 Compounds References
Bos taurus Trypsin I Compounds References
Bos taurus Trypsin II Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Mast cell protease 3 247 aa 28.6% 210 aa Compounds References
Sus scrofa Glandular kallikrein 246 aa 30.8% 221 aa Compounds References
Rattus norvegicus Tryptase alpha/beta-1 273 aa 35.4% 254 aa Compounds References
Rattus norvegicus Elastase 2A 271 aa 34.4% 256 aa Compounds References
Oryctolagus cuniculus Thrombin 235 aa 32.5% 231 aa Compounds References
Canis lupus familiaris Coagulation factor X 159 aa 32.7% 165 aa Compounds References
Sus scrofa Elastase 2A 269 aa 34.7% 248 aa Compounds References
Bos taurus Alpha-chymotrypsin 245 aa 33.5% 239 aa Compounds References
Bos taurus Beta-chymotrypsin 245 aa 34.3% 239 aa Compounds References
Sus scrofa Pancreatic elastase 269 aa 34.7% 248 aa Compounds References
Sus scrofa Elastase 1 266 aa 33.2% 247 aa Compounds References
Canis lupus familiaris Tryptase 275 aa 35.5% 248 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Sjp_0012180 (Schistosoma japonicum), ko:K09639 transmembrane protease, serine 8, putative
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