Detailed view for ML1985c

Basic information

TDR Targets ID: 979831
Mycobacterium leprae, PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL)
Source Database / ID:  Leproma 

pI: 6.071 | Length (AA): 798 | MW (Da): 89151 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00463  

Gene Ontology

Mouse over links to read term descriptions.
GO:0004451   isocitrate lyase activity  
GO:0003824   catalytic activity  
GO:0019752   carboxylic acid metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129572)

Species Accession Gene Product
Arabidopsis thaliana AT3G21720   isocitrate lyase
Candida albicans CaO19.14134   isocitrate lyase capable of functionally substituting for S. cerevisiae ICL1 (YER065C)
Candida albicans CaO19.6844   isocitrate lyase capable of functionally substituting for S. cerevisiae ICL1 (YER065C)
Dictyostelium discoideum DDB_G0273017   isocitrate lyase
Escherichia coli b4015   isocitrate lyase
Mycobacterium leprae ML1985c   PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL)
Mycobacterium tuberculosis Rv0467   Isocitrate lyase Icl (isocitrase) (isocitratase)
Mycobacterium tuberculosis Rv1915   Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl)
Mycobacterium tuberculosis Rv1916   Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl)
Mycobacterium ulcerans MUL_4536   isocitrate lyase Icl
Mycobacterium ulcerans MUL_2943   isocitrate lyase AceAb
Oryza sativa 4343441   Os07g0529000
Saccharomyces cerevisiae YPR006C   methylisocitrate lyase ICL2
Saccharomyces cerevisiae YER065C   isocitrate lyase 1

Essentiality

ML1985c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1946 Mycobacterium tuberculosis non-essential nmpdr
b4015 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Magnaporthe oryzae (strain 70-15 / FGSC 8958) (Rice blast fungus)(Pyricularia oryzae) Isocitrate lyase Compounds References
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) Compounds References
Candida albicans isocitrate lyase capable of functionally substituting for S. cerevisiae ICL1 (YER065C) Compounds References
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) Compounds References
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0546 0.5008 1
0.0493 0.2749 1
0.0914 0.628 1
0.0559002 1 1
0.3814 0.2595 1
0.0555 0.2843 1
0.0574 0.3393 1
0.1016 0.2985 0.7747
0.0583 0.4921 1
0.1168 0.7139 0.7131
0.251 0.7754 1
0.6625 0.901 1
0.0462 0.2842 1
0.0447 0.3561 1
0.1121 0.7653 1
0.0246 0.3406 1
0.0195 0.4446 1
0.0267 0.4481 0.9368
0.0861 0.6249 0.8521
0.0447 0.2705 1
0.0627 0.5961 1
0.0546 0.5008 1
0.21 0.971 1
0.0462 0.4934 1
0.0502 0.7146 1
0.1725 0.6797 0.6751
0.0696 0.2803 1
0.0327 0.2751 1
0.0627 0.3847 1
0.0875 0.4457 1
0.042 0.6561 0.6488
0.2683 0.369 1
0.0537 0.349 1
0.169 0.378 1
0.0627 0.3723 1
0.0525 0.3252 1
0.0381 0.5731 1
0.0823 0.2709 0.5645
0.0875 0.4457 1
0.0887 0.6595 1
0.0627 0.8223 1
0.0447 0.2705 1
0.0311 0.4891 1
0.2683 0.369 1
0.2683 0.369 1
0.0506 0.4847 0.5
0.0627 0.7019 1
0.052 0.6898 1
0.1506 0.6478 0.5344
0.1791 0.2838 0.6182
0.1734 0.9107 1
0.251 0.7754 1
0.1882 0.5654 1
0.048 0.6829 1
0.169 0.378 1
0.0525 0.3252 1
0.0476 0.2734 1
0.0559 0.5044 1
0.0571 0.3436 0.3314
0.1569 0.6478 0.5344
0.0696 0.2803 1
0.0914 0.628 1
0.0368 0.5594 1
0.1735 0.7153 1
0.0627 0.3847 1
0.0275 0.289 1
0.0487 0.2511 0.431
0.1077 0.4388 1
0.063 0.3929 1
0.0293 0.4109 1
0.0275 0.289 1
0.2683 0.369 1
0.3893 0.3472 0.3472
0.0987 0.5552 0.7577
0.0682 0.4388 1
0.0981 0.6043 0.8416
0.0819 0.3605 1
0.0524 0.2843 1
0.0558 0.7288 1
0.0311 0.4891 1
0.1735 0.7153 1
0.187 0.3182 0.6925
0.0875 0.4457 1
0.0502 0.7146 1
0.169 0.378 1
0.0583 0.4921 1
0.1015 0.4652 1
0.0616 0.6064 1
0.0454 0.812 1
0.0574 0.75 1
0.1702 0.3091 1
0.1008 0.2554 0.6415
0.0627 0.5961 1
0.0515 0.2749 1
0.0506 0.3596 0.4507
0.042 0.6561 0.6488
0.2683 0.369 1
0.0938 0.6249 0.8521
0.6358 0.2636 0.2636
0.169 0.378 1
0.0246 0.3406 1
0.0572 0.4425 1
0.0696 0.2803 1
0.1648 0.2588 1
0.1016 0.2985 0.7747
0.0506 0.3596 0.4507
0.0987 0.5552 0.7577
0.1882 0.6721 0.5344
0.0293 0.4109 1
0.6738 0.3381 1
0.1715 0.4184 0.6845
0.251 0.7754 1
0.1567 0.3191 0.6822
0.1882 0.5654 1
0.1735 0.7153 1
0.0627 0.3217 1
0.0515 0.2749 1
0.0943 0.2984 0.6259
0.0346 0.3922 1
0.0788 0.7694 1
0.0303 0.3104 0.3977
0.3213 0.3471 0.345
0.0483 0.7036 1
0.0875 0.4457 1
0.3893 0.3472 0.3472
0.0507 0.8023 1
0.0696 0.2803 1
0.4913 0.6303 1
0.1121 0.7653 1
0.22159 0.677339 0.677203
0.3289 0.265 0.347
0.0914 0.628 1
0.0594 0.596 1
0.187 0.3182 0.6925
0.0462 0.281 1
0.0987 0.5552 0.7577

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier ML1985c (Mycobacterium leprae), PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL)
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