Detailed view for Rv3608c

Basic information

TDR Targets ID: 980531
Mycobacterium tuberculosis, Dihydropteroate synthase 1 FolP (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate diphosphorylase 1)
Source Database / ID:  Tuberculist 

pI: 4.9393 | Length (AA): 280 | MW (Da): 28811 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00809  

Gene Ontology

Mouse over links to read term descriptions.
GO:0042558   pteridine and derivative metabolic process  
GO:0044237   cellular metabolic process  

Metabolic Pathways

Folate biosynthesis (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 274 1eye (A) 5 274 99.99 0 1 2.10829 -1.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128803)

Species Accession Gene Product
Arabidopsis thaliana AT4G30000   Dihydropterin pyrophosphokinase / Dihydropteroate synthase
Arabidopsis thaliana AT1G69190   bifunctional hydroxymethyldihydropterinpyrophosphokinase/ dihydropteroate synthase
Candida albicans CaO19.8210   likely pterin binding enzyme similar to S. cerevisiae FOL1 (YNL256W) involved in folic acid and derivative biosynthesis
Candida albicans CaO19.579   likely pterin binding enzyme similar to S. cerevisiae FOL1 (YNL256W) involved in folic acid and derivative biosynthesis
Chlamydia trachomatis CT_613   bifunctional 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase
Dictyostelium discoideum DDB_G0278283   dihydro-6-hydroxymethylpterin pyrophosphokinase
Escherichia coli b3177   7,8-dihydropteroate synthase
Mycobacterium leprae ML0224   Probable dihydropteroate synthase 1 FolP1 (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate dipyrophosphorylase 1)
Mycobacterium tuberculosis Rv3608c   Dihydropteroate synthase 1 FolP (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate diphosphorylase 1)
Mycobacterium ulcerans MUL_4190   dihydropteroate synthase 1 FolP1
Neospora caninum NCLIV_027230   Dihydropteroate synthase, related
Oryza sativa 4343919   Os07g0618500
Plasmodium berghei PBANKA_1426700   hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, putative
Plasmodium falciparum PF3D7_0810800   hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase
Plasmodium knowlesi PKNH_1429900   hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, putative
Plasmodium vivax PVX_123230   hydroxymethylpterin pyrophosphokinase-dihydropteroate synthetase, putative
Plasmodium yoelii PY02225   hypothetical protein
Plasmodium yoelii PY02226   dihydropteroate synthase, putative
Saccharomyces cerevisiae YNL256W   trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1
Toxoplasma gondii TGME49_259550   dihydropteroate synthase

Essentiality

Rv3608c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b3177 Escherichia coli essential goodall
YNL256W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1426700 Plasmodium berghei Essential plasmo
TGME49_259550 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Escherichia coli 7,8-dihydropteroate synthase Compounds References
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase Compounds References
Bacillus anthracis Dihydropteroate synthase Compounds References
Plasmodium berghei hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, putative Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0377 0.2701 1
0.0754 1 1
0.0304 1 1
0.0312 1 1
0.0319 0.3473 0.6827
0.0327 0.3506 0.6831
0.0319 0.3473 0.6827
0.0347 0.4128 1
0.1382 1 1
0.3588 1 1
0.0303 0.9895 1
0.0377 1 1
0.0377 0.5 0.5
0.0313 0.3477 0.6293
0.4359 1 1
0.0319 0.3473 0.6827
0.0316 0.316 1
0.0303 1 1
0.0333 0.9414 1
0.0377 0.5583 1
0.0954 1 1
0.0327 0.5395 0.6635
0.0347 0.4128 1
0.0319 0.54 0.6631
0.4868 1 1
0.0333 0.8271 1
0.0366 0.6645 1
0.0954 1 1
0.0996 1 1
0.3588 1 1
0.0251 0.475 1
0.0333 1 1
0.0251 0.475 1
0.031 0.3508 1
0.0366 0.6467 1
0.0304 0.3714 1
0.0326 0.4452 0.4762
0.4359 1 1
0.0311 0.6732 0.6626
0.0955 0.6907 1
0.0377 1 1
0.0377 1 1
0.0336 0.6078 0.6641
0.0236 0.5711 1
0.0304 1 1
0.0348 0.6446 1
0.0303 1 1
0.0667 1 1
0.0348 1 1
0.0377 0.4787 1
0.0223 0.5194 1
0.4359 1 1
0.0377 1 1
0.0251 0.3521 1
0.0377 1 1
0.4359 1 1
0.0311 0.6732 0.6626
0.4491 1 1
0.0307 0.9051 1
0.0344 0.344 0.6906
0.5498 1 1
0.4359 1 1
0.0316 0.316 1
0.0981 1 1
0.0303 0.5469 1
0.0311 0.6678 0.6628
0.0316 0.316 1
0.0652 1 1
0.0323 1 1
0.0377 0.2505 0.5442
0.0648 1 1
0.3588 1 1
0.0377 0.4791 1
0.0668 1 1
0.1273 0.3667 1
0.0673 0.5 0.5
0.0377 0.5 0.5
0.0302209 0.5 0.5
0.0377 0.2565 1
0.0728 0.5976 1
0.031 0.8631 1
0.0377 0.311 0.335
0.0668 1 1
0.0628 1 1
0.0754 1 1
0.5498 1 1
0.0648 1 1
0.0327 0.6154 0.6805
0.0311 0.6732 0.6626
0.4359 1 1
0.0954 1 1
0.4359 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv3608c (Mycobacterium tuberculosis), Dihydropteroate synthase 1 FolP (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate diphosphorylase 1)
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