Detailed view for Rv3545c

Basic information

TDR Targets ID: 980594
Mycobacterium tuberculosis, Probable cytochrome P450 125 Cyp125

Source Database / ID:  Tuberculist 

pI: 5.5888 | Length (AA): 433 | MW (Da): 48401 | Paralog Number: 10

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

Gene Ontology

Mouse over links to read term descriptions.
GO:0016705   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  
GO:0020037   heme binding  
GO:0005506   iron ion binding  
GO:0004497   monooxygenase activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
20 433 2x5l (A) 20 433 99.99 0 1 2.22002 -1.73

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132455)

Species Accession Gene Product
Escherichia coli b1803   putative YeaWX dioxygenase beta subunit, reductase component
Mycobacterium leprae ML2088c   putative cytochrome p450
Mycobacterium tuberculosis Rv3121   Probable cytochrome P450 141 Cyp141
Mycobacterium tuberculosis Rv3545c   Probable cytochrome P450 125 Cyp125
Mycobacterium tuberculosis Rv2776c   Probable oxidoreductase
Mycobacterium tuberculosis Rv0766c   Probable cytochrome P450 123 Cyp123
Mycobacterium tuberculosis Rv0778   Possible cytochrome P450 126 Cyp126
Mycobacterium tuberculosis Rv2266   Probable cytochrome P450 124 Cyp124
Mycobacterium tuberculosis Rv2268c   Probable cytochrome P450 128 Cyp128
Mycobacterium tuberculosis Rv1256c   Probable cytochrome P450 130 Cyp130
Mycobacterium tuberculosis Rv3518c   Probable cytochrome P450 monooxygenase 142 Cyp142
Mycobacterium tuberculosis Rv1785c   Probable cytochrome P450 143 Cyp143
Mycobacterium tuberculosis Rv1880c   Probable cytochrome P450 140 Cyp140
Mycobacterium ulcerans MUL_3872   cytochrome P450 187A5 Cyp187A5
Mycobacterium ulcerans MUL_1282   cytochrome P450 124A1, Cyp124A1
Mycobacterium ulcerans MUL_3106   cytochrome P450 143A3 Cyp143A3
Mycobacterium ulcerans MUL_0491   cytochrome P450 126A3 Cyp126A3
Mycobacterium ulcerans MUL_3863   cytochrome P450 108B4 Cyp108B4
Mycobacterium ulcerans MUL_0324   cytochrome P450 189A7 Cyp189A7
Mycobacterium ulcerans MUL_2159   oxidoreductase
Mycobacterium ulcerans MUL_0333   cytochrome P450 105Q4 Cyp105Q4
Mycobacterium ulcerans MUL_0475   cytochrome P450 123A3 Cyp123A3
Mycobacterium ulcerans MUL_4106   cytochrome P450 125A7 Cyp125A7
Mycobacterium ulcerans MUL_4077   cytochrome P450 142A3 Cyp142A3
Mycobacterium ulcerans MUL_3091   cytochrome P450 143A4 Cyp143A4
Mycobacterium ulcerans MUL_1049   cytochrome P450 191A3 Cyp191A3
Mycobacterium ulcerans MUL_0317   cytochrome P450 188A3 Cyp188A3
Mycobacterium ulcerans MUL_2979   cytochrome P450 140A5 Cyp140A5
Mycobacterium ulcerans MUL_3860   cytochrome P450 187A4 Cyp187A4
Mycobacterium ulcerans MUP053c   cytochrome p450 150 cyp150

Essentiality

Rv3545c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2301 Mycobacterium tuberculosis non-essential nmpdr
mtu2303 Mycobacterium tuberculosis essential nmpdr
mtu3579 Mycobacterium tuberculosis non-essential nmpdr
Mycobacterium tuberculosis non-essential nmpdr
b1803 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
References
References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Pseudomonas putida Cytochrome P450-cam Compounds References
Amycolatopsis orientalis Cytochrome P450 165B3 Compounds References
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0059 0.5 0.5
0.0004 0.5 0.5
0.0021 0.4036 0
0.0094 0.5 0.5
0.0015 0.5 0.5
0.0075 0.2816 0.5
0.0022 0.5 0.5
0.0049 0.6682 0.5
0.0004 0.5 0.5
0.0019 0.5 0.5
0.0114 1 0.5
0.0004 0.5 0.5
0.0267 0.27 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0235 0.3192 0.6178
0.0004 0.5 0.5
0.0029 1 0.5
0.0004 0.5 0.5
0.0071 0.9628 0.5
0.0166 0.2888 0
0.0066 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0099 0.7122 0.5
0.0011 0.5 0.5
0.0262 0.3083 1
0.0083 1 0.5
0.0067 0.5 0.5
0.0103 0.4147 0.4168
0.0004 0.5 0.5
0.0049 0.293 0.5
0.0084 0.3462 0.6551
0.0073 1 0.5
0.0122 0.4249 1
0.0051 0.4977 0.5
0.0289 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.033 0.3723 1
0.0035 0.4422 0.5
0.0004 0.5 0.5
0.0066 1 0.5
0.0004 0.5 0.5
0.0045 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0007 0.5 0.5
0.0067 0.5 0.5
0.0072 1 0.5
0.0104 0.5 0.5
0.0004 0.5 0.5
0.0025 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0202 0.2702 0.5446
0.0068 0.5 0.5
0.0069 0.5 0.5
0.00213675 0.269186 0.5
0.0245 1 1
0.0023 0.5 0.5
0.0015 0.5 0.5
0.0011 1 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0036 1 0.5
0.0232 0.2734 0.8833
0.0316 0.2652 0.7504
0.0388 0.2772 0.5
0.0004 0.5 0.5
0.0046 0.2608 0.5
0.0045 0.5 0.5
0.0011 0.5 0.5
0.0353 0.4928 0.5
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0007 1 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0081 0.5 0.5
0.000218985 0.5 0.5
0.0018 0.5 0.5
0.0063 0.3886 0.5
0.0004 0.5 0.5
0.0026 0.5 0.5
0.0004 0.5 0.5
0.0032 1 0.5
0.0016 1 0.5
0.0388 0.2772 0.5
0.0068 0.4312 1
0.002 0.5 0.5
0.0008 0.5 0.5
0.0011 1 0.5
0.0047 0.5 0.5
0.0289 0.2916 1
0.0004 0.5 0.5
0.0027 1 1
0.0004 1 0.5
0.0022 0.3789 0.5
0.0004 0.5 0.5
0.0082 0.5 0.5
0.0004 0.5 0.5
0.0063 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0082 0.5 0.5
0.0246 0.2667 0.5
0.00451124 0.405669 0.5
0.0021 0.5 0.5
0.0232 0.2734 0.8833
0.0015 0.5 0.5
0.0025 0.5 0.5
0.007 1 1
0.0102 0.3061 0.3937
0.0189 0.5524 0.5
0.0011 0.5 0.5
0.008 0.5 0.5
0.0004 0.5 0.5
0.0091 0.2951 1
0.0004 0.5 0.5
0.0368 0.2796 1
0.005 0.2698 0.5
0.0075 0.3265 0
0.007 0.5 0.5
0.0046 0.5 0.5
0.0012 1 0.5
0.0037 0.4283 0.5
0.0193 0.311 0
0.0004 0.5 0.5
0.002 1 0.5
0.0007 0.5 0.5
0.0007 0.5 0.5
0.0146 0.6069 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0119 0.4458 0.5
0.0057 0.2766 1
0.026 0.251 1
0.0016 0.5 0.5
0.00777519 0.280873 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0003 0.5 0.5
0.0059 0.6064 0.5
0.0004 0.5 0.5
0.0166 0.5366 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0008 0.3317 0
0.0084 1 0.5
0.0051 0.5 0.5
0.0032 1 0.5
0.0029 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0034 0.337 1
0.0004 0.5 0.5
0.0082 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0062 0.5 0.5
0.0118 0.3485 0.5
0.007 0.5713 0.5
0.0052 0.3825 0.5
0.0004 0.5 0.5
0.0228 0.2829 0.5
0.0011 0.5 0.5
0.0067 0.5 0.5
0.0019 0.5 0.5
0.0292 0.3488 1
0.0032 0.5 0.5
0.0032 0.5 0.5
0.0065 1 0.5
0.0004 0.5 0.5
0.0023 1 0.5
0.0075 1 0.5
0.0106 0.2751 1
0.0185 0.2528 0.5
0.0004 0.5 0.5
0.0014 0.5 0.5
0.0036 0.5 0.5
0.0059 0.6064 0.5
0.0044 0.6112 0.5
0.025 0.2789 0.5
0.0004 0.5 0.5
0.0323 0.2823 0.8288
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0012 0.5 0.5
0.0015 0.5 0.5
0.0004 0.5 0.5
0.0093 0.5 0.5
0.0011 0.5 0.5
0.0019 0.271 0.5
0.0022 0.3489 0.5
0.00139338 1 0.5
0.007 0.3303 0.4951
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0023 1 1
0.036 0.2841 0.7643
0.0124 0.2696 0.8052
0.0004 0.5 0.5
0.004 1 0.5
0.0004 0.5 0.5
0.026 0.251 1
0.004 1 1
0.0323 0.3673 1
0.0018 1 0.5
0.0019 0.271 0.5
0.0011 0.5 0.5
0.0045 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0059 0.6064 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0004 1 0.5
0.0004 0.5 0.5
0.0018 0.5 0.5
0.0004 0.5 0.5
0.0062 0.2905 1
0.0063 0.4653 0.5
0.0074 1 0.5
0.0081 0.5 0.5
0.0004 0.5 0.5
0.0167 0.2978 0.5
0.0007 0.5 0.5
0.033 0.3723 1
0.0361 0.2704 0.5
0.0004 0.5 0.5
0.0018 0.3602 0.5
0.000218985 0.5 0.5
0.0092 1 0.5
0.0004 0.5 0.5
0.0003 0.5 0.5
0.0052 0.2829 0.5
0.0011 1 0.5
0.0069 0.2847 0.4473
0.0004 1 0.5
0.0173 0.3858 0.5
0.0119 0.5 0.5
0.008 0.2556 1
0.0004 0.5 0.5
0.0027 0.5 0.5
0.006 0.2795 0.5
0.0058 0.5 0.5
0.0216 0.2583 0.5
0.0008 1 0.5
0.008 1 0.5
0.0083 0.6735 0.5
0.000396385 0.5 0.5
0.0026 0.5 0.5
0.0012 0.5 0.5
0.0086 0.5 0.5
0.0108 0.2733 1
0.0368 0.2796 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.00213675 0.269186 0.5
0.005 0.5 0.5
0.0068 1 0.5
0.0038 0.5102 0.5
0.0004 0.5 0.5
0.0071 0.5 0.5
0.0004 0.5 0.5
0.0156 0.4244 1
0.0033 0.5 0.5
0.0033 0.5 0.5
0.0015 0.5 0.5
0.0324 0.2701 1
0.00109509 1 0.5
0.005 0.3622 0.5
0.0419 0.49 1
0.0217 0.8044 0.5
0.0033 0.5 0.5
0.0133 0.2787 0.8245
0.0004 0.5 0.5
0.0002 0.5 0.5
0.0044 0.2627 0
0.0331 0.3985 1
0.0176 0.3425 1
0.0004 0.5 0.5
0.0042 0.5 0.5
0.0023 0.5 0.5
0.01 0.5 0.5
0.0048 1 0.5
0.00213675 0.269186 0.5
0.0059 0.5 0.5
0.0008 0.5 0.5
0.0007 0.5 0.5
0.0275 0.314 1
0.0033 0.2605 0.5
0.0044 0.4237 0.5
0.0284 0.2924 1
0.0042 1 0.5
0.0203 0.2689 0.5
0.0028 0.5 0.5
0.0103 1 0.5
0.0284 0.2726 1
0.004 1 0.5
0.004 0.5565 0.5
0.0004 0.5 0.5
0.0033 0.3348 0.5
0.0078 0.3003 0.5792
0.0065 0.3393 0.3393
0.0047 0.6689 0.5
0.0004 0.5 0.5
0.008 0.2582 1
0.0012 0.5 0.5
0.0012 0.5 0.5
0.034 0.2765 0.5
0.0036 0.4353 0.5
0.00213675 0.269186 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0038 1 0.5
0.005 1 0.5
0.0111 0.3549 0.362
0.0038 0.5 0.5
0.0047 0.6638 0.5
0.0063 0.2543 0.5
0.0046 0.6591 1
0.0073 1 0.5
0.0004 0.5 0.5
0.0197 0.6846 0.5
0.0076 1 1
0.0092 0.467 0.5
0.0046 0.6591 1
0.000376403 0.5 0.5
0.0003 0.5 0.5
0.0407 0.5243 1
0.0028 0.5 0.5
0.0072 1 0.5
0.0087 1 0.5
0.0032 0.5 0.5
0.0078 1 0.5
0.0146 0.6654 0.5
0.003 0.3514 0.5
0.0007 0.5 0.5
0.0569 0.2624 1
0.0326 0.2819 0.5
0.0008 0.5 0.5
0.0008 0.3317 0
0.0018 0.5 0.5
0.0137 0.271 1
0.0235 0.2812 1
0.0164 0.3784 0.5
0.0084 0.5 0.5
0.0018 0.2637 0.5
0.0249 0.3082 0.5
0.0007 0.5 0.5
0.0254 0.3494 1
0.0054 0.5 0.5
0.0019 0.5 0.5
0.0316 0.2652 0.7504
0.0284 0.2924 1
0.0037 0.2694 1
0.0286 1 1
0.0004 0.5 0.5
0.0046 0.5 0.5
0.015 0.2827 0.5891
0.0174 0.2937 0.5
0.0004 0.5 0.5
0.0336 0.2847 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0173 0.3457 0
0.0018 0.5 0.5
0.0071 0.3514 0.5
0.0008 0.5 0.5
0.0114 1 0.5
0.0232 0.2734 0.8833
0.0004 0.5 0.5
0.0047 0.6638 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0145 0.7126 0.5
0.0119 0.4458 0.5
0.013 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0026 0.5 0.5
0.0008 0.5 0.5
0.0063 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0012 0.5 0.5
0.00184047 0.269186 0.5
0.0018 0.2876 0.5
0.0052 0.3769 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0048 0.6597 0.5
0.0004 0.5 0.5
0.0071 0.2928 0.5
0.0184 0.3352 0.9605
0.0042 0.3378 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0443 0.3118 1
0.0019 0.5 0.5
0.0018 0.5004 0.5
0.033 0.3723 1
0.0065 0.5 0.5
0.0004 0.5 0.5
0.0083 0.5 0.5
0.0254 0.3494 1
0.0029 0.36 0.5
0.0051 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0104893 0.26658 1
0.0184 0.3508 0.5
0.0341 0.2689 0.5
0.0056 0.3577 1
0.0099 0.7062 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0004 0.5 0.5
0.0087 1 0.5
0.0069 1 0.5
0.0004 0.5 0.5
0.0018 0.5004 0.5
0.0004 0.5 0.5
0.0094 0.2887 0.5
0.0073 0.5 0.5
0.0353 0.4928 0.5
0.0054 1 0.5
0.0004 0.5 0.5
0.0067 0.5 0.5
0.0055 0.2887 0.5
0.007 1 1
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0022 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0053 1 0.5
0.0291 0.2657 0.5
0.0157 0.3541 0.5
0.0012 0.5 0.5
0.0133 0.256 0.5
0.0569 0.2624 1
0.0007 1 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.004 1 0.5
0.0127 0.5337 0.5
0.0008 0.5 0.5
0.0121 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0004 0.5 0.5
0.0016 1 0.5
0.0217 0.2742 0.5
0.00505219 0.5 0.5
0.0048 0.6634 0.5
0.0004 0.5 0.5
0.003 0.3271 0.5
0.0346 0.2559 0.6171
0.0065 1 0.5
0.0004 0.5 0.5
0.0018 0.5 0.5
0.0103 0.6953 1
0.0268 0.2982 1
0.0004 0.5 0.5
0.0079 0.2909 0.5653
0.0071 0.5 0.5
0.0027 1 0.5
0.0254 0.3494 1
0.0059 0.6064 0.5
0.0019 0.2756 0.5
0.0004 0.5 0.5
0.0036 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0055 0.5 0.5
0.0008 0.5 0.5
0.0077 0.5 0.5
0.0056 0.6399 0.5
0.0011 0.5 0.5
0.015 0.3435 0.5
0.0162 0.2769 1
0.0004 0.5 0.5
0.0028 0.2972 1
0.0023 0.9674 0.5
0.0004 0.5 0.5
0.0331 0.3985 1
0.004 1 0.5
0.0057 0.2766 1
0.0004 0.5 0.5
0.0051 0.3758 0.5
0.015 0.2827 0.5891
0.000376403 0.5 0.5
0.0038 0.525 0.5
0.0093 0.3481 0.6382

Assayability

Assay information

  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis His4-tagged recombinant CYP125 expressed in Escherichia coli HMS174(DE3) by UV-visible spectral titration method
  • ChEMBL
  • Activity of Mycobacterium tuberculosis CYP125A1 assessed as compound oxidation at 50 uM incubated for 1 hr at 25 degC by GC-MS method
  • ChEMBL
  • Time dependent inhibition of Mycobacterium tuberculosis CYP125A1 at 50 uM incubated up to 3 hrs by HPLC
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis CYP125A1 by UV-visible spectrophotometry
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis CYP125A1 assessed as type 1 binding mode at 0.05 to 0.2 uM by UV-visible spectrophotometry
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis CYP125A1 assessed as type 1a binding mode at > 0.05 to 0.2 uM by UV-visible spectrophotometry
  • ChEMBL
  • Activity of Mycobacterium tuberculosis CYP125A1 assessed as apparent turnover number at 50 uM incubated for 1 hr at 25 degC by GC-MS method
  • ChEMBL
  • Activity of Mycobacterium tuberculosis CYP125A1 assessed as relative apparent turnover number at 50 uM incubated for 1 hr at 25 degC by GC-MS method relative to cholesterol

Reagent availability

No reagent availability information for this target.

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Gene identifier Rv3545c (Mycobacterium tuberculosis), Probable cytochrome P450 125 Cyp125
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