Detailed view for Rv3624c

Basic information

TDR Targets ID: 980670
Mycobacterium tuberculosis, Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor

Source Database / ID:  Tuberculist 

pI: 4.7173 | Length (AA): 216 | MW (Da): 23604 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 214 6ar9 (A) 9 226 26.00 0 1 1.18668 -0.54
30 216 4rhx (B) 16 202 99.99 0 1 2.08004 -1.86

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127374)

Species Accession Gene Product
Arabidopsis thaliana AT1G71750   hypoxanthine phosphoribosyltransferase
Brugia malayi Bm1_19890   Phosphoribosyl transferase domain containing protein
Caenorhabditis elegans CELE_Y105E8B.5   Protein Y105E8B.5
Dictyostelium discoideum DDB_G0285193   hypoxanthine phosphoribosyltransferase
Escherichia coli b0125   hypoxanthine phosphoribosyltransferase
Echinococcus granulosus EgrG_000758800   hypoxanthine guanine phosphoribosyltransferase
Echinococcus granulosus EgrG_000758900   hypoxanthine guanine phosphoribosyltransferase
Echinococcus multilocularis EmuJ_000758900   hypoxanthine guanine phosphoribosyltransferase
Echinococcus multilocularis EmuJ_000758800   hypoxanthine guanine phosphoribosyltransferase
Giardia lamblia GL50803_6436   Guanine phosphoribosyltransferase
Homo sapiens ENSG00000099256   phosphoribosyl transferase domain containing 1
Homo sapiens ENSG00000165704   hypoxanthine phosphoribosyltransferase 1
Leishmania braziliensis LbrM.21.0990   hypoxanthine-guanine phosphoribosyltransferase
Leishmania braziliensis LbrM.21.1000   xanthine phosphoribosyltransferase
Leishmania donovani LdBPK_210990.1   xanthine phosphoribosyltransferase
Leishmania donovani LdBPK_210980.1   hypoxanthine-guanine phosphoribosyltransferase
Leishmania infantum LinJ.21.0990   xanthine phosphoribosyltransferase
Leishmania infantum LinJ.21.0980   hypoxanthine-guanine phosphoribosyltransferase
Leishmania major LmjF.21.0845   hypoxanthine-guanine phosphoribosyltransferase
Leishmania major LmjF.21.0850   xanthine phosphoribosyltransferase
Leishmania mexicana LmxM.21.0850   xanthine phosphoribosyltransferase
Leishmania mexicana LmxM.21.0845   hypoxanthine-guanine phosphoribosyltransferase
Mycobacterium leprae ML0214   Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho
Mus musculus ENSMUSG00000025630   hypoxanthine guanine phosphoribosyl transferase
Mycobacterium tuberculosis Rv3624c   Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor
Mycobacterium ulcerans MUL_4200   hypoxanthine-guanine phosphoribosyltransferase Hpt
Neospora caninum NCLIV_038170   Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8), related
Onchocerca volvulus OVOC11850  
Plasmodium berghei PBANKA_1210800   hypoxanthine-guanine phosphoribosyltransferase, putative
Plasmodium falciparum PF3D7_1012400   hypoxanthine-guanine phosphoribosyltransferase
Plasmodium knowlesi PKNH_0812200   hypoxanthine-guanine phosphoribosyltransferase, putative
Plasmodium vivax PVX_094840   hypoxanthine-guanine phosphoribosyltransferase, putative
Schistosoma japonicum Sjp_0023450   Hypoxanthine-guanine phosphoribosyltransferase, putative
Schistosoma japonicum Sjp_0023460   ko:K00760 hypoxanthine phosphoribosyltransferase [EC2.4.2.8], putative
Schistosoma mansoni Smp_168500   hypoxanthine-guanine phosphoribosyltransferase
Schistosoma mansoni Smp_103560   hypoxanthine-guanine phosphoribosyltransferase
Schmidtea mediterranea mk4.002646.06  
Schmidtea mediterranea mk4.000023.23  
Schmidtea mediterranea mk4.005084.05  
Schmidtea mediterranea mk4.016658.00  
Schmidtea mediterranea mk4.016685.01  
Schmidtea mediterranea mk4.013413.00  
Schmidtea mediterranea mk4.001970.04  
Schmidtea mediterranea mk4.010510.00  
Trypanosoma brucei gambiense Tbg972.10.1690   hypoxanthine-guanine phosphoribosyltransferase, putative
Trypanosoma brucei gambiense Tbg972.10.1600   hypoxanthine-guanine phosphoribosyltransferase, putative
Trypanosoma brucei gambiense Tbg972.10.1590   hypoxanthine-guanine phosphoribosyltransferase, putative
Trypanosoma brucei Tb927.10.1400   hypoxanthine-guanine phosphoribosyltransferase
Trypanosoma brucei Tb927.10.1470   hypoxanthine-guanine phosphoribosyltransferase
Trypanosoma brucei Tb927.10.1390   hypoxanthine-guanine phosphoribosyltransferase, putative
Trypanosoma congolense TcIL3000_10_1180   hypoxanthine-guanine phosphoribosyltransferase, putative
Trypanosoma congolense TcIL3000_10_1280   hypoxanthine-guanine phosphoribosyltransferase
Trypanosoma congolense TcIL3000_10_1170   hypoxanthine-guanine phosphoribosyltransferase, putative
Trypanosoma cruzi TcCLB.509693.80   hypoxanthine-guanine phosphoribosyltransferase, putative
Trypanosoma cruzi TcCLB.506457.40   hypoxanthine-guanine phosphoribosyltransferase, putative
Trypanosoma cruzi TcCLB.509693.70   hypoxanthine-guanine phosphoribosyltransferase, putative
Trypanosoma cruzi TcCLB.506457.30   hypoxanthine-guanine phosphoribosyltransferase, putative
Toxoplasma gondii TGME49_200320   hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT
Trichomonas vaginalis TVAG_243770   hypoxanthine-guanine phosphoribosyltransferase, putative

Essentiality

Rv3624c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.1390 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.1390 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.1390 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.10.1390 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.1400 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.1400 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.1400 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.1400 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
b0125 Escherichia coli non-essential goodall
PBANKA_1210800 Plasmodium berghei Slow plasmo
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase Compounds References
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative Compounds References
Homo sapiens hypoxanthine phosphoribosyltransferase 1 Compounds References
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative Compounds References
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase Compounds References
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative Compounds References
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative Compounds References
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative Compounds References
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase Compounds References
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0354 0.7558 1
0.1323 0.7643 1
0.0211 0.2837 0.5471
0.0148 0.2604 1
0.0298 0.6218 1
0.0145 0.2658 1
0.1546 0.3232 1
0.0141 0.284 1
0.0153 0.4136 1
0.1827 0.7617 1
0.1245 0.7641 1
0.1472 0.6943 1
0.0139 0.7524 0.895
0.007 0.6943 1
0.0153 0.385 1
0.1546 0.3232 1
0.007 0.7394 1
0.155 0.7604 1
0.0147 0.6943 1
0.0176 0.2875 1
0.0339 0.7519 1
0.072 0.7644 1
0.0288 0.7557 1
0.0227 0.4783 0.5
0.0153 0.385 1
0.1084 0.7607 1
0.1387 0.7578 1
0.0137 0.26 1
0.1094 0.7621 1
0.1546 0.3232 1
0.0136 0.434 1
0.0446 0.364 1
0.0151 0.2665 0.3361
0.0145 0.2583 1
0.0275 0.7473 0.9902
0.1143 0.7651 1
0.0071 0.4091 0.3596
0.0148 0.6108 0.6108
0.037 0.3236 1
0.007 0.4091 0.3596
0.0145 0.3134 0.5
0.0085 0.6943 1
0.0153 0.3801 1
0.0275 0.7473 0.9902
0.0153 0.3801 1
0.0292 0.6848 0.5
0.0143 0.6527 1
0.0441 0.7614 1
0.0147 0.2858 0.2858
0.0502 0.6625 1
0.0139 0.3766 1
0.0148 0.6108 0.6108
0.0073 0.5959 0.5
0.1089 0.7652 1
0.0446 0.7277 1
0.0148 0.7087 1
0.0145 0.2599 1
0.036 0.6985 1
0.0837 0.7642 1
0.0796 0.709 1
0.1165 0.7637 1
0.0152 0.7384 1
0.0441 0.7614 1
0.1932 0.763 1
0.0296 0.7427 1
0.015 0.434 1
0.0791 0.7652 1
0.007 0.7451 1
0.0145 0.2637 1
0.0161 0.4085 1
0.0151 0.6753 1
0.007 0.5905 1
0.0145 0.292 1
0.0647 0.7554 1
0.0145 0.6478 1
0.0428 0.4387 1
0.1197 0.6943 1
0.1245 0.7641 1
0.037 0.3236 1
0.0446 0.364 1
0.0072 0.4091 0.3596
0.0595 0.7545 1
0.0141 0.284 1
0.0153 0.3801 1
0.0085 0.6283 0.5
0.0068 0.4107 0.3596
0.0142 0.7517 0.8468
0.1483 0.7627 1
0.0498 0.6628 1
0.0158 0.5858 1
0.0141 0.284 1
0.1827 0.7617 1
0.0069 0.7177 1
0.015 0.7544 1
0.1158 0.7642 1
0.133 0.7653 1
0.007 0.7394 1
0.0446 0.364 1
0.0139 0.7524 0.895
0.1827 0.7617 1
0.0145 0.3469 0.7891
0.0153 0.3801 1
0.0085 0.719 1
0.0145 0.292 1
0.0296 0.6696 1
0.0517 0.7081 1
0.0153 0.4136 1
0.0718 0.7601 1
0.1083 0.7582 1
0.0069 0.6943 1
0.0141 0.284 1
0.0148 0.5346 0.8147
0.0146 0.2565 1
0.0139 0.7524 0.895
0.0148 0.6108 0.6108
0.0085 0.6943 1
0.0428 0.4387 1
0.155 0.7604 1
0.0145 0.5016 0.4341
0.0148 0.5245 0.8077
0.0796 0.709 1
0.0069 0.5972 0.5
0.0221 0.4432 1
0.0145 0.2637 1
0.1165 0.7637 1
0.0085 0.5756 0.7356
0.0152 0.6447 0.5
0.0374 0.7373 1
0.1245 0.7641 1
0.0441 0.4432 1
0.1156 0.7613 1
0.1088 0.7229 1
0.0145 0.292 1
0.0142 0.2649 1
0.0144 0.2534 1
0.1024 0.764 1
0.037 0.3236 1
0.1327 0.765 1
0.0085 0.6739 0.5
0.1465 0.7651 1
0.0283 0.4841 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Rv3624c (Mycobacterium tuberculosis), Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor
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